The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA
Abstract
A significant fraction of DNA damage produced by ionizing radiation comes from free radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl radical, the principal damaging species, produces single-strand breaks and a plethora of base and sugar lesions that can be cytotoxic or mutagenic. Free radical-induced DNA damage is repaired by an efficient and ubiquitous process called "base excision repair" which is composed of either three or four enzymatic steps, depending on the initial lesion. The result is an intact DNA molecule with a short repair patch size. If, however, multiply damaged sites similar to those produced by ionizing radiation are processed by base excision repair, a double-strand break can result if the opposing lesions are more than three nucleotides apart. Because base excision repair evolved to protect the genome from endogenous damages, the proteins involved are highly conserved from bacteria to humans, not only at the functional level, but at the level of amino acid sequence.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA
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Reactions of oxyl radicals with DNA
Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038
Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair
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Biochemical Basis of DNA Replication Fidelity
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Cited by
Role of oxygen radicals in DNA damage and cancer incidence
Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820
Free radical-induced damage to DNA: mechanisms and measurement
Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953
Paganetti, H. (2014) · Physics in Medicine and Biology · doi:10.1088/0031-9155/59/22/r419 · Cited by 915
Gasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.2987 · Cited by 542
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Metadata
- Authors
- Wallace, S. S.
- Venue
- Radiation Research
- Publisher
- JSTOR
- Published
- 1998-11
- Volume
- 150
- Issue
- 5
- Pages
- S60
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W2127136618
- Cited by
- 334
- References
- 11
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
