Phagocyte partnership during the onset and resolution of inflammation
Abstract
Neutrophils, monocytes and macrophages are closely related phagocytic cells that cooperate during the onset, progression and resolution of inflammation. This Review highlights the mechanisms involved in the intimate partnership of phagocytes during each progressive phase of the inflammatory response. We describe how tissue-resident macrophages recognize tissue damage to promote the recruitment of neutrophils and the mechanisms by which infiltrating neutrophils can then promote monocyte recruitment. Furthermore, we discuss the phagocyte-derived signals that abrogate neutrophil recruitment and how the uptake of apoptotic neutrophils by macrophages leads to termination of the inflammatory response. Finally, we highlight the potential therapeutic relevance of these interactions.
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“So this pathway limits the APC response to DAMPs but is not activated by PAMPs and might therefore help to avoid unnecessary collateral damage in the absence of pathogen”
BackgroundDivergent effects of tumor necrosis factor alpha on apoptosis of human neutrophils.
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Self-citationControl of granule exocytosis in neutrophils
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Self-citationChemerin Peptides Promote Phagocytosis in a ChemR23- and Syk-Dependent Manner
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Self-citationResident Pleural Macrophages Are Key Orchestrators of Neutrophil Recruitment in Pleural Inflammation
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Neutrophil recruitment and function in health and inflammation
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Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
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Regulation of the Inflammatory Response in Cardiac Repair
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mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
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Neutrophil migration in infection and wound repair: going forward in reverse
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Resolvins and protectins in inflammation resolution
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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps
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DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation
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Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
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The neutrophil in vascular inflammation
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Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
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Self-citationResolution of inflammation: an integrated view
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Self-citationSatellite Cells and Skeletal Muscle Regeneration
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Impact of Obesity and Metabolic Syndrome on Immunity
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Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis
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Diverse novel functions of neutrophils in immunity, inflammation, and beyond
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The role of neutrophils during intestinal inflammation
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Sterile inflammation in the liver
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Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies
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Neutrophils in tissue injury and repair
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Pathophysiology of Myocardial Infarction
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Neutrophils as protagonists and targets in chronic inflammation
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Self-citationNeutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis
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5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease
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Multiple Roles for Neutrophils in Atherosclerosis
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Self-citationCurrent Advances in Immunomodulatory Biomaterials for Bone Regeneration
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Neutrophils: Cinderella of innate immune system
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Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
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Mechanism of Immunopotentiation and Safety of Aluminum Adjuvants
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Inflammation: Mechanisms, Costs, and Natural Variation
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Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
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Cellular dynamics in the muscle satellite cell niche
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Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response
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- Authors
- Soehnlein, O., & Lindbom, L.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Soehnlein, Oliver
- Venue
- Nature Reviews Immunology
- Published
- 2010-06
- Volume
- 10
- Issue
- 6
- Pages
- 427-439
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2074171762
- Cited by
- 1,054
- References
- 138
- Citations by year
- 2026: 34 · 2025: 44 · 2024: 61 · 2023: 50 · 2022: 73 · 2021: 80 · 2020: 59 · 2019: 58 · 2018: 56 · 2017: 65 · 2016: 75 · 2015: 61 · 2014: 61 · 2013: 104 · 2012: 71
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neutrophils, monocytes, macrophages, inflammation resolution, neutrophil recruitment, monocyte recruitment, tissue-resident macrophages, therapeutic targeting
- MeSH terms
- Animals, Cell Movement, Homeostasis, Humans, Inflammation, Phagocytes, Signal Transduction, Apoptosis
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