Cited by 1,054Phagocytosis and Immune RegulationNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancer

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, Oliver, Lindbom, Lennart·2010·Nature Reviews Immunology

Abstract

Neutrophils, monocytes and macrophages are closely related phagocytic cells that cooperate during the onset, progression and resolution of inflammation. This Review highlights the mechanisms involved in the intimate partnership of phagocytes during each progressive phase of the inflammatory response. We describe how tissue-resident macrophages recognize tissue damage to promote the recruitment of neutrophils and the mechanisms by which infiltrating neutrophils can then promote monocyte recruitment. Furthermore, we discuss the phagocyte-derived signals that abrogate neutrophil recruitment and how the uptake of apoptotic neutrophils by macrophages leads to termination of the inflammatory response. Finally, we highlight the potential therapeutic relevance of these interactions.

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Crossref · 10.1038/nri2779

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Authors
Soehnlein, O., & Lindbom, L.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Soehnlein, Oliver
Venue
Nature Reviews Immunology
Published
2010-06
Volume
10
Issue
6
Pages
427-439
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2074171762
Cited by
1,054
References
138
Citations by year
2026: 34 · 2025: 44 · 2024: 61 · 2023: 50 · 2022: 73 · 2021: 80 · 2020: 59 · 2019: 58 · 2018: 56 · 2017: 65 · 2016: 75 · 2015: 61 · 2014: 61 · 2013: 104 · 2012: 71
FWCI
6.95
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
neutrophils, monocytes, macrophages, inflammation resolution, neutrophil recruitment, monocyte recruitment, tissue-resident macrophages, therapeutic targeting
MeSH terms
Animals, Cell Movement, Homeostasis, Humans, Inflammation, Phagocytes, Signal Transduction, Apoptosis

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