Apolipoprotein E synthesis in human kidney, adrenal gland, and liver
Open accessAbstract
Human tissues were incubated in vitro with radiolabeled amino acids to determine whether plasma apolipoproteins are synthesized in human kidney. Subsequently, tissue extracts were screened with antisera directed against apolipoprotein E (apo E), apolipoprotein B (apo B), apolipoprotein AI (apo AI), and bulk apolipoproteins of high density lipoprotein (HDL). Newly synthesized apo E, but not apo AI or apo B, was identified in kidney and adrenal cortex. Estimates of relative rates of apo E synthesis in vitro suggest that a substantial portion of adrenal and kidney protein synthesis is committed to apo E synthesis. The relative rate of apo E synthesis was 4-6 times greater in kidney cortex than in kidney medulla. Analysis of immunoreactive apo E showed that kidney and adrenal apo E species have the same electrophoretic mobility in NaDodSO4/polyacrylamide gels as does plasma apo E. Further characterization by high resolution two-dimensional gel analysis indicated that the isoforms of newly synthesized kidney and adrenal apo E correspond to specific isoforms of plasma apo E. These findings suggest that apolipoproteins arising from peripheral tissues may play an important role in lipid transport and metabolism.
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Although liver is the major source of apoE in the circulation, apoE is also synthesized by the kidney, with a substantial portion of kidney protein synthesis committed to apoE synthesis.
“Although liver is the major source of apoE in the circulation, apoE is also synthesized by the kidney, with a substantial portion of kidney protein synthesis committed to apoE synthesis (43).”
From Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy (2018) · cites this paper as [43]
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- Authors
- Blue, M. L., Williams, D. L., Zucker, S., Khan, S. A., & Blum, C. B.
- Affiliations
- State University of New York (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1983-01
- Volume
- 80
- Issue
- 1
- Pages
- 283-287
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC393357
- OpenAlex
- W1990815703
- Cited by
- 226
- References
- 2
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 24.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein E, apolipoprotein synthesis, kidney, adrenal cortex, liver, apolipoprotein B, apolipoprotein A-I, high-density lipoprotein, tissue protein synthesis, lipid transport, kidney cortex and medulla
- MeSH terms
- Adrenal Glands, Apolipoproteins, Apolipoproteins E, Humans, Isoelectric Point, Kidney, Liver, Molecular Weight
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