The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.
Open accessAbstract
Transferrin is required by many cells for growth. Mitogen-induced T lymphocyte proliferation is dependent on the presence of both interleukin 2 (IL-2; T-cell growth factor) and transferrin, even though resting lymphocytes do not have receptors for either. Exposure to mitogen (phytohemagglutinin) alone is sufficient to induce transient appearance of IL-2 receptors on lymphocytes. Using monoclonal antibodies to the IL-2 receptor and to the transferrin receptor, we examined those signals required for transferrin receptor induction during T lymphocyte proliferation. Our study has revealed that (i) monocytes, or a monocyte substitute such as the phorbol ester tetradecanoylphorbol 13-acetate, are required for transferrin receptor expression after mitogen exposure; (ii) the presence of IL-2 receptors is necessary for transferrin receptor induction; (iii) antibody to the IL-2 receptor inhibits thymidine incorporation (DNA synthesis) in lymphocytes, but only if administered before transferrin receptors have appeared; and (iv) antitransferrin receptor antibody inhibits DNA synthesis but has minimal effect on IL-2 receptor expression. Thus, IL-2 receptor induction leads to transferrin receptor induction and subsequent initiation of DNA synthesis. These data indicate that IL-2 stimulates T lymphocyte proliferation, at least in part, by induction of transferrin receptors on these cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sutherland, R., Delia, D., Schneider, C., Newman, R., Kemshead, J., & Greaves, M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4515 · Cited by 685
Cited by
Nutrient acquisition strategies of mammalian cells
Palm, W., & Thompson, C. B. (2017) · Nature · doi:10.1038/nature22379 · Cited by 388
The Role of Iron Regulation in Immunometabolism and Immune-Related Disease
Cronin, S. J. F., Woolf, C. J., Weiss, G., & Penninger, J. M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00116 · Cited by 299
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency
Jabara, H. H., Boyden, S. E., Chou, J., Ramesh, N., Massaad, M. J., Benson, H., Bainter, W., Fraulino, D., Rahimov, F., Sieff, C., et al. (2016) · Nature Genetics · doi:10.1038/ng.3465 · Cited by 279
The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
Kwok, J. C., & Richardson, D. R. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00213-x · Cited by 215
Porto, G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4707 · Cited by 140
Transferrin receptor 1 is differentially required in lymphocyte development
Ned, R. M., Swat, W., & Andrews, N. C. (2003) · Blood · doi:10.1182/blood-2003-04-1086 · Cited by 120
Tsuji, Y., Miller, L. L., Miller, S. C., Torti, S. V., & Torti, F. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89638-0 · Cited by 103
Immune system development varies according to age, location, and anemia in African children
Hill, D. L., Carr, E. J., Rutishauser, T., Moncunill, G., Campo, J. J., Innocentin, S., Mpina, M., Nhabomba, A., Tumbo, A., Jairoce, C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw9522 · Cited by 89
Trypanosoma cruzi receptors for human transferrin and their role
LIMA, M., & VILLALTA, F. (1990) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(90)90027-j · Cited by 58
A Clonal CD4-Positive T-Cell Line Established from the Blood of a Patient with Sézary Syndrome
Abrams, J. T., Lessin, S., Ghosh, S. K., Ju, W., Vonderheid, E. C., Nowell, P., Murphy, G., Elfenbein, B., & DeFreitas, E. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12514693 · Cited by 51
Iron regulates T-lymphocyte sensitivity to the IFN-γ/STAT1 signaling pathway in vitro and in vivo
Regis, G., Bosticardo, M., Conti, L., De Angelis, S., Boselli, D., Tomaino, B., Bernabei, P., Giovarelli, M., & Novelli, F. (2005) · Blood · doi:10.1182/blood-2004-07-2686 · Cited by 50
Metadata
- Authors
- Neckers, L. M., & Cossman, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-06
- Volume
- 80
- Issue
- 11
- Pages
- 3494-3498
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002796914
- Cited by
- 447
- References
- 1
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
