Nutrient acquisition strategies of mammalian cells

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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mTOR Signaling in Growth Control and Disease

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The emerging hallmarks of cancer metabolism

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Regulation of cancer cell metabolism

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Fundamentals of Cancer Metabolism

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

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Molecular mechanism and physiological functions of clathrin-mediated endocytosis

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Two to tango: Regulation of Mammalian iron metabolism

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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Autophagy and Metabolism

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A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

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Nutrition Needs of Mammalian Cells in Tissue Culture

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

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Pancreatic cancers require autophagy for tumor growth

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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Targeting metastasis-initiating cells through the fatty acid receptor CD36

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

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Lipid metabolism in cancer

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

Guo, J. Y., Chen, H.-Y., Mathew, R., Fan, J., Strohecker, A. M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemons, J. M. S., Karantza, V., et al. (2011) · Genes & Development · doi:10.1101/gad.2016311 · Cited by 1,323 · see citing works

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D., & Thompson, C. B. (2015) · Nature · doi:10.1038/nature13981 · Cited by 1,007 · see citing works

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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Shaping cups into phagosomes and macropinosomes

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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2211 · Cited by 893 · see citing works

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Inoki, K., Kim, J., & Guan, K. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134537 · Cited by 800 · see citing works

Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes

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Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K. J., Singh, D. K., Sirasanagandla, S., Nannepaga, S., Piccirillo, S. G., Kovacs, Z., Foong, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.025 · Cited by 760 · see citing works

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

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Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by <i>ras</i> Proteins

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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

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Nutrient sensing and TOR signaling in yeast and mammals

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The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

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Acetate dependence of tumors

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AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

Mayers, J. R., Wu, C. H., Clish, C. B., Kraft, P., Torrence, M. E., Fiske, B. P., Yuan, C., Bao, Y., Townsend, M. K., Tworoger, S. S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3686 · Cited by 652 · see citing works

Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

Hosios, A. M., Hecht, V. C., Danai, L. V., Johnson, M. O., Rathmell, J. C., Steinhauser, M. L., Manalis, S. R., & Vander Heiden, M. G. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.012 · Cited by 641 · see citing works

The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

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Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

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�ber den Stoffwechsel der Carcinomzelle

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Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

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Untitled work

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Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

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Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

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Tissue of origin dictates branched-chain amino acid metabolism in mutant <i>Kras</i> -driven cancers

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Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

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Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

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Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

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ATP citrate lyase is an important component of cell growth and transformation

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Transferrin receptors in human tissues: their distribution and possible clinical relevance.

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Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

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Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

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Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

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Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

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Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth

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BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

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Apoptotic cell removal

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Albumin as Fatty Acid Transporter

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

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In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

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The utilization of extracellular proteins as nutrients is suppressed by mTORC1

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Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.

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An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

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Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

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Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

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The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

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Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

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Acidosis orchestrates adaptations of energy metabolism in tumors

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Reexamining How Cancer Cells Exploit the Body's Metabolic ResourcesPreprint

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