The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.
Open accessAbstract
A pigeon cytochrome c-specific and Ia molecule-restricted T-cell hybrid was used as an immunogen in order to obtain monoclonal anti-antigen receptor antibodies. Two antibodies were isolated that specifically bound to and inhibited interleukin (IL) 2 release from only the immunizing clone. Lectin-induced IL 2 release was not affected by these antibodies. Binding assays with purified and iodinated monoclonal antibody indicated that there were approximately equal to 25,000 binding sites on the T-cell hybrid. Immunoprecipitation and NaDodSO4/polyacrylamide gel electrophoresis of detergent lysates from surface-labeled hybrid cells revealed a heterodimeric structure composed of chains of apparent Mrs 45,000-50,000 and 40,000-44,000. The chains were linked by intermolecular disulfide bonds, and the difference in migration of the isolated chains under reducing and nonreducing conditions was consistent with the presence of intramolecular disulfide bonds. The molecule that has been identified is a candidate for the antigen-specific receptor on the immunizing T-cell clone.
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Cites
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A better cell line for making hybridomas secreting specific antibodies
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Genes of the Major Histocompatibility Complex of the Mouse
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Cited by
T-cell antigen receptor genes and T-cell recognition
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Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
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Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.
Samelson, L. E., Phillips, A. F., Luong, E. T., & Klausner, R. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4358 · Cited by 623
Self-citationA Di-Acidic Signal Required for Selective Export from the Endoplasmic Reticulum
Nishimura, N., & Balch, W. E. (1997) · Science · doi:10.1126/science.277.5325.556 · Cited by 485
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Metadata
- Authors
- Samelson, L. E., Germain, R. N., & Schwartz, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-11
- Volume
- 80
- Issue
- 22
- Pages
- 6972-6976
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2045217835
- Cited by
- 289
- References
- 12
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Samelson, L. E., Germain, R. N., & Schwartz, R. H. (1983). Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.22.6972
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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