The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Domains in viroids: evidence of intermolecular RNA rearrangements and their contribution to viroid evolution.
Open accessAbstract
On the basis of sequence homology a model is proposed for five structural and functional domains in viroids. These domains include (i) a conserved central region capable of forming two alternative structures that may regulate two phases of the viroid replication cycle, (ii) a region associated with pathogenicity, (iii) a domain with high sequence variability, (iv and v) two terminal domains that are interchangeable between viroids. That the evolution of viroids has involved RNA rearrangements of domains is supported by the partial duplication of coconut cadang cadang viroid, which arises de novo during each infection. Similar RNA rearrangements have been established for animal viral defective interfering RNAs, which arise by some form of discontinuous transcription. This mechanism could account for the origin of viroids and also RNA viruses, whereby modules of genetic information may have undergone repeated exchange between RNA pathogens and the RNA of their hosts.
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Nucleotide sequence and secondary structure of potato spindle tuber viroid
Gross, H. J., Domdey, H., Lossow, C., Jank, P., Raba, M., Alberty, H., & Sänger, H. L. (1978) · Nature · doi:10.1038/273203a0 · Cited by 508
A Replication Cycle for Viroids and Other Small Infectious RNA's
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A THEORY OF MODULAR EVOLUTION FOR BACTERIOPHAGES*
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Nucleotide Sequence and Secondary Structure of Citrus Exocortis and Chrysanthemum Stunt Viroid
GROSS, H. J., KRUPP, G., DOMDEY, H., RABA, M., JANK, P., LOSSOW, C., ALBERTY, H., SÄNGER, H. L., & RAMM, K. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05779.x · Cited by 222
Structure and structure formation of viroids
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Self-citationStructural similarities between viroids and transposable genetic elements.
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Cited by
Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
Forster, A. C., & Symons, R. H. (1987) · Cell · doi:10.1016/0092-8674(87)90562-9 · Cited by 666
Self-citationSelf-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid
Hutchins, C. J., Rathjen, P. D., Forster, A. C., & Symons, R. H. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.9.3627 · Cited by 585
Self-citationDomingo, E., Martínez-Salas, E., Sobrino, F., de la Torre, J. C., Portela, A., Ortín, J., López-Galindez, C., Pérez-Breña, P., Villanueva, N., Nájera, R., et al. (1985) · Gene · doi:10.1016/0378-1119(85)90017-4 · Cited by 503
Viroids and Viroid-Host Interactions
Flores, R., Hernández, C., Alba, A. E. M. D., Daròs, J.-A., & Serio, F. D. (2005) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.43.040204.140243 · Cited by 462
Viroids: an Ariadne's thread into the RNA labyrinth
Daròs, J., Elena, S. F., & Flores, R. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400706 · Cited by 106
Metadata
- Authors
- Keese, P., & Symons, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-07
- Volume
- 82
- Issue
- 14
- Pages
- 4582-4586
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973968273
- Cited by
- 425
- References
- 15
- FWCI
- 21.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Keese, P., & Symons, R. H. (1985). Domains in viroids: evidence of intermolecular RNA rearrangements and their contribution to viroid evolution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.14.4582
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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