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Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.
Open accessAbstract
Overlapping recombinant clones that encompass the insulin-like growth factor (IGF) I and II genes have been isolated from a human genomic DNA library. Each gene is present once per haploid genome; the IGF-I gene spans greater than 35 kilobase pairs (kbp) and the IGF-II gene is at least 15 kbp. The exon-intron organization of these genes is similar, each having four exons, which is one more than the related insulin gene. Comparison of the restriction endonuclease cleavage maps of the IGF-II and insulin genes, including their flanking regions and hybridization with an IGF-II cDNA probe, revealed that they are adjacent to one another. The IGF-II and insulin genes have the same polarity and are separated by 12.6 kbp of intergenic DNA that includes a dispersed middle repetitive Alu sequence. The order of the genes is 5'-insulin-IGF-II-3'.
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Citations
Cited by
Bell, G. I., Horita, S., & Karam, J. H. (1984) · Diabetes · doi:10.2337/diab.33.2.176 · Cited by 743
Self-citationRegulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 553
Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*
MATHEWS, L. S., HAMMER, R. E., BEHRINGER, R. R., D'ERCOLE, A. J., BELL, G. I., BRINSTER, R. L., & PALMITER, R. D. (1988) · Endocrinology · doi:10.1210/endo-123-6-2827 · Cited by 477
Self-citationParental genomic imprinting of the human IGF2 gene
Giannoukakis, N., Deal, C., Paquette, J., Goodyer, C. G., & Polychronakos, C. (1993) · Nature Genetics · doi:10.1038/ng0593-98 · Cited by 441
MURPHY, L. J., BELL, G. I., & FRIESEN, H. G. (1987) · Endocrinology · doi:10.1210/endo-120-4-1279 · Cited by 416
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Metadata
- Authors
- Bell, G. I., Gerhard, D. S., Fong, N. M., Sanchez-Pescador, R., & Rall, L. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-10
- Volume
- 82
- Issue
- 19
- Pages
- 6450-6454
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977579221
- Cited by
- 208
- References
- 0
- FWCI
- 17.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Bell, G. I., Gerhard, D. S., Fong, N. M., Sanchez-Pescador, R., & Rall, L. B. (1985). Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.19.6450
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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