The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.
Open accessAbstract
The major isoenzymes of cytosolic glutathione transferase (EC 2.5.1.18) from rat, mouse, and man are shown to share structural and catalytic properties that can be used for species-independent classification. Rat, mouse, and human isoenzymes were grouped with respect to amino-terminal amino acid sequences, after correlation of seven structures analyzed in the present investigation with structures determined earlier. The isoenzymes were also characterized by substrate specificities and sensitivities to inhibitors, and the data were subjected to pattern recognition analysis. In addition, the various isoenzymes were tested for cross-reactivity by immunoprecipitation with antibodies raised against rat and human transferases. The different types of data were clearly correlated and afforded an unambiguous division of the isoenzymes into three classes named alpha, mu, and pi. Each of the three mammalian species studied contains at least one isoenzyme of each class. It is suggested that the similarities of the isoenzymes in a class reflect evolutionary relationships and that the classification applies generally.
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Cites
[51] Assays for differentiation of glutathione S-Transferases
Habig, W. H., & Jakoby, W. B. (1981) · Methods in Enzymology · doi:10.1016/s0076-6879(81)77053-8 · Cited by 2,419
Cited by
SHEEHAN, D., MEADE, G., FOLEY, V. M., & DOWD, C. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600001 · Cited by 3,057
Watson, M. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.275 · Cited by 668
Treskes, N., Persoon, A. M., & van Zanten, A. R. H. (2017) · Internal and Emergency Medicine · doi:10.1007/s11739-017-1668-y · Cited by 135
Phylogenies of glutathione transferase families
Pearson, W. R. (2005) · Methods in Enzymology · doi:10.1016/s0076-6879(05)01012-8 · Cited by 105
Structural insights into Charcot–Marie–Tooth disease‐linked mutations in human GDAP1
Sutinen, A., Nguyen, G. T. T., Raasakka, A., Muruganandam, G., Loris, R., Ylikallio, E., Tyynismaa, H., Bartesaghi, L., Ruskamo, S., & Kursula, P. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13422 · Cited by 13
Metadata
- Authors
- Mannervik, B., Alin, P., Guthenberg, C., Jensson, H., Tahir, M. K., Warholm, M., & Jörnvall, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-11
- Volume
- 82
- Issue
- 21
- Pages
- 7202-7206
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2090874882
- Cited by
- 1,071
- References
- 1
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Mannervik, B., Alin, P., Guthenberg, C., Jensson, H., Tahir, M. K., Warholm, M., & Jörnvall, H. (1985). Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.21.7202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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