The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.
Open accessAbstract
A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (beta protein), induced antibodies in BALB/c mice that were used immunohistochemically to stain not only amyloid-laden cerebral vessels but neuritic plaques as well. These findings suggest that the amyloid in neuritic plaques shares antigenic determinants with beta protein of cerebral vessels. Since the amino acid compositions of plaque amyloid and cerebrovascular amyloid are similar, it is likely that plaque amyloid also consists of beta protein. This possibility suggests a model for the pathogenesis of Alzheimer disease involving beta protein.
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Cites
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Self-citationAmyloid Deposits and Amyloidosis: The β-Fibrilloses(First of Two Parts)
Glenner, G. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006053022305 · Cited by 1,790
Self-citationAlzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693
Self-citationImmunogenic structure of the influenza virus hemagglutinin
Green, N., Alexander, H., Olson, A., Alexander, S., Shinnick, T. M., Sutcliffe, J. G., & Lerner, R. A. (1982) · Cell · doi:10.1016/0092-8674(82)90202-1 · Cited by 756
Anderton, B. H., Breinburg, D., Downes, M. J., Green, P. J., Tomlinson, B. E., Ulrich, J., Wood, J. N., & Kahn, J. (1982) · Nature · doi:10.1038/298084a0 · Cited by 531
Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy.
Costa, P. P., Figueira, A. S., & Bravo, F. R. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4499 · Cited by 427
ROTH, M., TOMLINSON, B. E., & BLESSED, G. (1966) · Nature · doi:10.1038/209109a0 · Cited by 298
Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys
Wiśniewski, H. M., Ghetti, B., & Terry, R. D. (1973) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197310000-00007 · Cited by 272
Miyakawa, T., Shimoji, A., Kuramoto, R., & Higuchi, Y. (1982) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02932857 · Cited by 217
Cohen, D. H., Feiner, H., Jensson, O., & Frangione, B. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.2.623 · Cited by 193
Cited by
The molecular pathology of Alzheimer's disease
Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513
Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type
Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1990) · Science · doi:10.1126/science.2111584 · Cited by 1,381
Roles of tau protein in health and disease
Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940
Metadata
- Authors
- Wong, C. W., Quaranta, V, & Glenner, G. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-12
- Volume
- 82
- Issue
- 24
- Pages
- 8729-8732
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2086207996
- Cited by
- 438
- References
- 20
- FWCI
- 30.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Wong, C. W., Quaranta, V, & Glenner, G. G. (1985). Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.24.8729
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
