Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects
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The seminal articles of Blessed et al, Roth et al, and Tomlinson et al found a correlation between dementia severity and amyloid plaques counted in cerebral cortex.
“Studies not shown in Table 5 include the seminal articles of Blessed et al (254), Roth et al (255), and Tomlinson et al (38, 256), which found a correlation between dementia severity and amyloid plaques counted in cerebral cortex (with the caveat described previously)”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [255]
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“Studies not shown in Table 5 include the seminal articles of Blessed et al (254), Roth et al (255), and Tomlinson et al (38, 256), which found a correlation between dementia severity and amyloid plaques counted in cerebral cortex (with the caveat described previously), and previous studies that had…”
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Self-citationReisberg, ., Monteiro, I. M., Torossian, C. L., Auer, S., Shulman, M. B., Ghimire, S., Boksay, I., Guillo‐Benarous, F., Osorio, R. S., Vengassery, A., et al. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000357839 · Cited by 63 · see citing works
Beta-amyloid Formation as a Potential Therapeutic Target for Alzheimer's Disease
Cordell, B. (1994) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.34.040194.000441 · Cited by 63 · see citing works
Ultrastructure of Senile Dementia and of Experimental Analogs
Terry, R. D., & Wı́sniewski, H. M. (1972) · Advances in behavioral biology · doi:10.1007/978-1-4684-8503-5_7 · Cited by 63 · see citing works
- Authors
- ROTH, M., TOMLINSON, B. E., & BLESSED, G.
- Affiliations
- Royal Victoria Infirmary (GB)
- ORCID
- ROTH, M.
- Venue
- Nature
- Published
- 1966-01
- Volume
- 209
- Issue
- 5018
- Pages
- 109-110
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2036801925
- Cited by
- 298
- References
- 7
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 6 · 2012: 11
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- amyloid plaques, senile dementia, dementia severity, postmortem neuropathology, elderly patients, age-related cognitive decline
- MeSH terms
- Aged, Cerebral Cortex, Dementia, Humans, Middle Aged, Psychological Tests
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