The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Evidence for higher rates of nucleotide substitution in rodents than in man.
Open accessAbstract
When the coding regions of 11 genes from rodents (mouse or rat) and man are compared with those from another mammalian species (usually bovine), it is found that rodents evolve significantly faster than man. The ratio of the number of nucleotide substitutions in the rodent lineage to that in the human lineage since their divergence is 2.0 for synonymous substitutions and 1.3 for nonsynonymous substitutions. Rodents also evolve faster in the 5' and 3' untranslated regions of five different mRNAs; the ratios are 2.6 and 3.1, respectively. The numbers of nucleotide substitutions between members of the beta-globin gene family that were duplicated before the man-mouse split are also higher in mouse than in man. The difference is, again, greater for synonymous substitutions than for nonsynonymous substitutions. This tendency is more consistent with the neutralist view of molecular evolution than with the selectionist view. A simple explanation for the higher rates in rodents is that rodents have shorter generation times and, thus, higher mutation rates. The implication of our findings for the study of molecular phylogeny is discussed.
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Cites
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Jarvis, E. D., Mirarab, S., Aberer, A. J., Li, B., Houde, P., Li, C., Ho, S. Y. W., Faircloth, B. C., Nabholz, B., Howard, J. T., et al. (2014) · Science · doi:10.1126/science.1253451 · Cited by 1,901
Estimating the rate of evolution of the rate of molecular evolution
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The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
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Body size, metabolic rate, generation time, and the molecular clock.
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Metadata
- Authors
- Wu, C. I., & Li, W. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-03
- Volume
- 82
- Issue
- 6
- Pages
- 1741-1745
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1997188744
- Cited by
- 913
- References
- 40
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- green
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