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Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.
Open accessAbstract
Bovine basic fibroblast growth factor (bFGF) is a potent mitogen isolated from bovine pituitary glands and brain. The addition of homogeneous bFGF to primary cultures of rat cerebral cortical neurons markedly enhances cell survival and elaboration of neurites. These effects are dose-dependent, with optimal stimulation occurring at a concentration of 500 pg/ml. Maintenance of survival and neurite outgrowth require the continuous presence of bFGF. Other growth factors, such as thrombin, platelet-derived growth factor, beta nerve growth factor, and interleukin 2, have no effect on neuronal survival or process formation. Although the cellular site(s) of bFGF synthesis has not yet been established, these results suggest that bFGF may function as a neurotrophic agent in the central nervous system.
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Citations
Cites
Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture
Banker, G. A. (1980) · Science · doi:10.1126/science.7403847 · Cited by 674
Cited by
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630
Mattson, M., Murrain, M., Guthrie, P., & Kater, S. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03728.1989 · Cited by 480
Hefti, F., Hartikka, J., & Knusel, B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90118-8 · Cited by 466
Lai, C., & Lemke, G. (1991) · Neuron · doi:10.1016/0896-6273(91)90167-x · Cited by 443
Metadata
- Authors
- Morrison, R. S., Sharma, A., de Vellis, J., & Bradshaw, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-10
- Volume
- 83
- Issue
- 19
- Pages
- 7537-7541
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027399729
- Cited by
- 686
- References
- 1
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Morrison, R. S., Sharma, A., de Vellis, J., & Bradshaw, R. A. (1986). Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.19.7537
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
