Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329 · see citing works

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,282 · see citing works

Identification of a receptor for the morphogen retinoic acid

Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965 · see citing works

Purification of a new neurotrophic factor from mammalian brain.

Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822 · see citing works

Physiology of nerve growth factor.

Thoenen, H., & Barde, Y. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,590 · see citing works

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,455 · see citing works

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

Strickland, S., & Mahdavi, V. (1978) · Cell · doi:10.1016/0092-8674(78)90008-9 · Cited by 1,420 · see citing works

Actions of Insulin-Like Growth Factors

Froesch, E. R., Schmid, C., Schwander, J., & Zapf, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002303 · Cited by 1,154 · see citing works

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120 · see citing works

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988) · Nature · doi:10.1038/331528a0 · Cited by 1,093 · see citing works

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083 · see citing works

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

Williams, L. R., Varon, S. S., Peterson, G. M., Wictorin, K., Fischer, W., Björklund, A., & Gage, F. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.9231 · Cited by 1,055 · see citing works

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

Ponte, P. A., Gonzalez‐DeWhitt, P. A., Schilling, J., Miller, J., Hsu, D. K., Greenberg, B., Davis, K. L., Wallace, W., Lieberburg, I. M., Fuller, F. H., et al. (1988) · Nature · doi:10.1038/331525a0 · Cited by 1,050 · see citing works

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

Fischer, W., Wictorin, K., Björklund, A., Williams, L., Varon, S. S., & Gage, F. H. (1987) · Nature · doi:10.1038/329065a0 · Cited by 1,024 · see citing works

Identification of a second human retinoic acid receptor

Brand, N. J., Petkovich, M. P., Krust, A., Chambon, P., de Thé, H., Marchio, A., Tiollais, P., & Dejean, A. (1988) · Nature · doi:10.1038/332850a0 · Cited by 1,022 · see citing works

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

Heumann, R., Korsching, S. I., Bandtlow, C. E., & Thoenen, H. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.6.1623 · Cited by 1,022 · see citing works

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

Lindholm, D., Heumann, R., Meyer, M., & Thoenen, H. (1987) · Nature · doi:10.1038/330658a0 · Cited by 994 · see citing works

Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.

Abraham, J., Mergia, A., Whang, J., Tumolo, A., Friedman, J. M., Hjerrild, K. A., Gospodarowicz, D., & Fiddes, J. (1986) · Science · doi:10.1126/science.2425435 · Cited by 987 · see citing works

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

Hamburger, V., & Levi‐Montalcini, R. (1949) · Journal of Experimental Zoology · doi:10.1002/jez.1401110308 · Cited by 985 · see citing works

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

Korsching, S. I., Auburger, G. W. J., Heumann, R., Scott, J., & Thoenen, H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03791.x · Cited by 938 · see citing works

Gene transfer and molecular cloning of the rat nerve growth factor receptor

Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938 · see citing works

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

Kromer, L. F. (1987) · Science · doi:10.1126/science.3798108 · Cited by 932 · see citing works

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 893 · see citing works

Insulin-like growth factor II receptor as a multifunctional binding protein

Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., & Rutter, W. J. (1987) · Nature · doi:10.1038/329301a0 · Cited by 853 · see citing works

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847 · see citing works

Peptide growth factors are multifunctional

Sporn, M. B., & Roberts, A. B. (1988) · Nature · doi:10.1038/332217a0 · Cited by 830 · see citing works

Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.

Jones-Villeneuve, E., McBurney, M. W., Rogers, K. A., & Kalnins, V. I. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.94.2.253 · Cited by 783 · see citing works

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

Walicke, P. A., Cowan, W. M., Ueno, N., Baird, A., & Guillemin, R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.3012 · Cited by 735 · see citing works

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

Greene, L. A., & Shooter, E. M. (1980) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.03.030180.002033 · Cited by 734 · see citing works

The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain

Nicoll, R. A. (1988) · Science · doi:10.1126/science.2456612 · Cited by 729 · see citing works

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

Gnahn, H., Hefti, F. F., Heumann, R., Schwab, M. E., & Thoenen, H. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90107-4 · Cited by 719 · see citing works

Transforming growth factor α

Derynck, R. (1988) · Cell · doi:10.1016/s0092-8674(88)80001-1 · Cited by 703 · see citing works

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

Heumann, R., Lindholm, D., Bandtlow, C. E., Meyer, M., Radeke, M. J., Misko, T. P., Shooter, E. M., & Thoenen, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8735 · Cited by 700 · see citing works

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

Appel, S. H. (1981) · Annals of Neurology · doi:10.1002/ana.410100602 · Cited by 698 · see citing works

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

Morrison, R. S., Sharma, A., de Vellis, J., & Bradshaw, R. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7537 · Cited by 687 · see citing works

Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain

Woolf, N. J., & Butcher, L. L. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90134-6 · Cited by 668 · see citing works

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

Lindsay, R. M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02394.1988 · Cited by 662 · see citing works

Cell death in the development of the lateral motor column of the chick embryo

Hamburger, V. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901600408 · Cited by 660 · see citing works

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

Thiele, C. J., Reynolds, C. P., & Israel, M. A. (1985) · Nature · doi:10.1038/313404a0 · Cited by 649 · see citing works

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

Rechler, M. M., & Nissley, S. P. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002233 · Cited by 642 · see citing works

An immunohistochemical study of the nerve growth factor receptor in developing rats

Yan, Q., & Johnson, E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03481.1988 · Cited by 605 · see citing works

Cholinergic function and intellectual decline in Alzheimer's disease

Collerton, D. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90002-3 · Cited by 602 · see citing works

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

Abraham, J. A., Whang, J. L., Tumolo, A., Mergia, A., Friedman, J. S., Gospodarowicz, D., & Fiddes, J. C. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04530.x · Cited by 594 · see citing works

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

Seiler, M. J., & Schwab, M. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)91338-6 · Cited by 592 · see citing works

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

Anderson, K. J., Dam, D., Lee, S., & Cotman, C. W. (1988) · Nature · doi:10.1038/332360a0 · Cited by 590 · see citing works

Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.

Korsching, S. I., & Thoenen, H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.11.3513 · Cited by 562 · see citing works

Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

Hirsch, É. C., Graybiel, A. M., Duyckaerts, C. J., & Javoy-Agid, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5976 · Cited by 554 · see citing works

The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery

Thoenen, H., Bandtlow, C. E., & Heumann, R. (1987) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0031026 · Cited by 553 · see citing works

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

Davies, A. M., Bandtlow, C. E., Heumann, R., Korsching, S. I., Rohrer, H., & Thoenen, H. (1987) · Nature · doi:10.1038/326353a0 · Cited by 548 · see citing works

Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum

Rye, D. B., Saper, C. B., Lee, H. J., & Wainer, B. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902590403 · Cited by 545 · see citing works

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

Taniuchi, M., Clark, H., Schweitzer, J. B., & Johnson, E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00664.1988 · Cited by 542 · see citing works

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

Leong, K. W., Brott, B. C., & Langer, R. (1985) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820190806 · Cited by 541 · see citing works

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

Shelton, D. L., & Reichardt, L. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2714 · Cited by 532 · see citing works

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

Walicke, P. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02618.1988 · Cited by 532 · see citing works

Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor

Gundersen, R. W., & Barrett, J. N. (1979) · Science · doi:10.1126/science.493992 · Cited by 523 · see citing works

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

Whittemore, S. R., Ebendal, T., Lärkfors, L., Olson, L., Seiger, Å., Strömberg, I., & Persson, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.817 · Cited by 522 · see citing works

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

Johnson, J., Barde, Y., Schwab, M. E., & Thoenen, H. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-03031.1986 · Cited by 520 · see citing works

Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.

Shelton, D. L., & Reichardt, L. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7951 · Cited by 519 · see citing works

Purification of the Chick Eye Ciliary Neuronotrophic Factor

Barbin, G., Manthorpe, M., & Varon, S. S. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05410.x · Cited by 515 · see citing works

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

Rosenberg, M. B., Friedmann, T., Robertson, R., Tuszynski, M. H., Wolff, J. A., Breakefield, X. O., & Gage, F. H. (1988) · Science · doi:10.1126/science.3201248 · Cited by 505 · see citing works

Thyroid Hormones and Brain Development

Dussault, J. H., & Ruel, J. (1987) · Annual Review of Physiology · doi:10.1146/annurev.ph.49.030187.001541 · Cited by 500 · see citing works

Brain-derived neurotrophic factor prevents neuronal death in vivo

Hofer, M., & Barde, Y. (1988) · Nature · doi:10.1038/331261a0 · Cited by 497 · see citing works

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

Johnson, E. M., Gorin, P. D., Brandeis, L., & Pearson, J. (1980) · Science · doi:10.1126/science.7192014 · Cited by 496 · see citing works

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

Whittemore, S. R., & Seiger, Å. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90008-7 · Cited by 492 · see citing works

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

Hefti, F. F., Hartikka, J., Eckenstein, F. P., Gnahn, H., Heumann, R., & Schwab, M. E. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90163-0 · Cited by 491 · see citing works

Monomeric insulins obtained by protein engineering and their medical implications

Brange, J., Ribel, U., Hansen, J. F., Dodson, G. G., Hansen, M. T., Havelund, S., Melberg, S., Norris, F., Norris, K. E., Snel, L. I. P., et al. (1988) · Nature · doi:10.1038/333679a0 · Cited by 489 · see citing works

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., & Johnston, M. V. (1985) · Science · doi:10.1126/science.2861660 · Cited by 480 · see citing works

Differential expression of insulin-like growth factor genes in rat central nervous system.

Rotwein, P. S., Burgess, S. K., Milbrandt, J., & Krause, J. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.265 · Cited by 474 · see citing works

Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells

Gospodarowicz, D., Neufeld, G., & Schweigerer, L. (1986) · Cell Differentiation · doi:10.1016/0045-6039(86)90021-7 · Cited by 471 · see citing works

Gene Transfer and Molecular Cloning of the Human NGF Receptor

Chao, M. V., Bothwell, M. A., Ross, A. H., Koprowski, H., Lanahan, A. A., Buck, C. R., & Sehgal, A. (1986) · Science · doi:10.1126/science.3008331 · Cited by 449 · see citing works

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

Hefti, F. F., Dravid, A. R., & Hartikka, J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91237-x · Cited by 447 · see citing works

Nerve Growth Factor Gene Expression in the Developing Rat Brain

Large, T. H., Bodary, S. C., Clegg, D., Weskamp, G., Otten, U., & Reichardt, L. F. (1986) · Science · doi:10.1126/science.3764415 · Cited by 435 · see citing works

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

Recio‐Pinto, E., Mm, R., & Ishii, D. N. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-05-01211.1986 · Cited by 429 · see citing works

Adhesion molecules and the hierarchy of neural development

Jessell, T. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90204-8 · Cited by 425 · see citing works

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

Schwab, M. E., Otten, U., Agid, Y., & Thoenen, H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90303-2 · Cited by 416 · see citing works

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413 · see citing works

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

Hatten, M. E., Lynch, M., Rydel, R. E., Sanchez, J. H., Joseph‐Silverstein, J., Moscatelli, D., & Rifkin, D. B. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90211-4 · Cited by 408 · see citing works

Distribution of neuronal receptors for nerve growth factor in the rat

Richardson, P., Issa, V. M. K., & Riopelle, R. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02312.1986 · Cited by 393 · see citing works

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

McMorris, F. A., Smith, T., DeSalvo, S., & Furlanetto, R. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.822 · Cited by 386 · see citing works

Nerve growth factor and Alzheimer's disease

Hefti, F. F., & Weiner, W. J. (1986) · Annals of Neurology · doi:10.1002/ana.410200302 · Cited by 383 · see citing works

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Gemski, J., Buchanan, K., & Johnston, M. V. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90020-3 · Cited by 380 · see citing works

Purification and characterization of a neurite extension factor from bovine brain.

KLIGMAN, D. E., & Marshak, D. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7136 · Cited by 379 · see citing works

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

Finklestein, S. P., Apostolides, P. J., Caday, C. G., Prosser, J. M., Philips, M. F., & Klagsbrun, M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90370-8 · Cited by 379 · see citing works

Retinoic Acid-Induced Growth Inhibition and Morphologic Differentiation of Human Neuroblastoma Cells In Vitro 2

Sidell, N. (1982) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/68.4.589 · Cited by 378 · see citing works

Fibroblast growth factor

Gospodarowicz, D., Neufeld, G., & Schweigerer, L. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90001-8 · Cited by 373 · see citing works

Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues.

Heumann, R., Korsching, S. I., Scott, J., & Thoenen, H. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02277.x · Cited by 357 · see citing works

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

Rydel, R. E., & Greene, L. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-11-03639.1987 · Cited by 356 · see citing works

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

Lièvre, C. A., Olson, L., Ebendal, T., Seiger, Å., & Persson, H. (1988) · Science · doi:10.1126/science.2897715 · Cited by 356 · see citing works

Neurochemical Studies of Early-Onset Alzheimer's Disease

Francis, P. T., Palmer, A. M., Sims, N. R., Bowen, D. M., DAVISON, A. N., Esiri, M. M., Neary, D., Snowden, J. S., & Wilcock, G. K. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507043130102 · Cited by 353 · see citing works

New Perspectives on Alzheimer's Disease

Price, D. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002421 · Cited by 352 · see citing works

Cellular localization of nerve growth factor synthesis by in situ hybridization.

Bandtlow, C. E., Heumann, R., Schwab, M. E., & Thoenen, H. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04835.x · Cited by 343 · see citing works

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

Hughes, S. M., Lillien, L. E., RAFF, M. C., Rohrer, H., & Sendtner, M. (1988) · Nature · doi:10.1038/335070a0 · Cited by 342 · see citing works

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

Goedert, M., Fine, A., Hunt, S. P., & Ullrich, A. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90023-9 · Cited by 338 · see citing works

Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues

Baird, A., Esch, F. S., Mormède, P., Ueno, N., LING, N. C., Böhlen, P., Ying, S., Wehrenberg, W. B., & Guillemin, R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-571142-5.50008-2 · Cited by 337 · see citing works

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

Neufeld, G., & Gospodarowicz, D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57261-1 · Cited by 336 · see citing works

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

Gensburger, C., Labourdette, G., & Sensenbrenner, M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81230-9 · Cited by 334 · see citing works

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

Pearson, R. C. A., Sofroniew, M. V., Cuello, A. C., Powell, T. P. S., Eckenstein, F. P., Esiri, M. M., & Wilcock, G. K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90046-x · Cited by 334 · see citing works

Insulin and insulin-like growth factors in the CNS

Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., & Dorsa, D. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90155-5 · Cited by 330 · see citing works

Morphological response of axotomized septal neurons to nerve growth factor

Gage, F. H., Armstrong, D. M., Williams, L. R., & Varon, S. S. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902690112 · Cited by 321 · see citing works

The Biology and Mechanism of Action of Nerve Growth Factor

Yankner, B. A., & Shooter, E. M. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.004213 · Cited by 321 · see citing works

STUDIES OF THE CONNEXIONS OF THE FORNIX SYSTEM

Daitz, H. M., & Powell, T. P. S. (1954) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.17.1.75 · Cited by 320 · see citing works

Receptor- and heparin-binding domains of basic fibroblast growth factor.

Baird, A., Schubert, D., LING, N. C., & Guillemin, R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2324 · Cited by 320 · see citing works

Development of Septal Cholinergic Neurons in Culture: Plating Density and Glial Cells Modulate Effects of NGF on Survival, Fiber Growth, and Expression of Transmitter-Specific Enzymes

Hartikka, J., & Hefti, F. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02967.1988 · Cited by 317 · see citing works

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

Rich, K. M., Luszczynski, J. R., Osborne, P. A., & Johnson, E. M. (1987) · Journal of Neurocytology · doi:10.1007/bf01795309 · Cited by 317 · see citing works

Rat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus

Whittemore, S. R., Friedman, P. L., Larhammar, D., Persson, H., Gonzalez-Carvajal, M., & Holets, V. R. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200402 · Cited by 308 · see citing works

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

Gioor, S., Odink, K. G., Guenther, J., Nick, H., & Monard, D. (1986) · Cell · doi:10.1016/0092-8674(86)90511-8 · Cited by 296 · see citing works

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

Morrison, R. S., Kornblum, H. I., Leslie, F. M., & Bradshaw, R. A. (1987) · Science · doi:10.1126/science.3498986 · Cited by 294 · see citing works

Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures

Honegger, P., & Lenoir, D. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90023-2 · Cited by 293 · see citing works

Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain

Hefti, F. F., Hartikka, J., Salvatierra, A. T., Weiner, W. J., & Mash, D. C. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90410-6 · Cited by 290 · see citing works

Developmental Neurobiology and the Natural History of Nerve Growth Factor

Levi‐Montalcini, R. (1982) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.05.030182.002013 · Cited by 288 · see citing works

Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase

Wainer, B. H., Levey, A. I., Mufson, E. J., & Mesulam, M. M. (1984) · Neurochemistry International · doi:10.1016/0197-0186(84)90089-5 · Cited by 287 · see citing works

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

OTTO, D., Unsicker, K., & Grothe, C. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90233-3 · Cited by 285 · see citing works

Thyroid Hormones and Brain Development

(1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197711000-00013 · Cited by 277 · see citing works

The brain fibroblast growth factor (FGF) is localized in neurons

Pettmann, B., Labourdette, G., Weibel, M., & Sensenbrenner, M. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90137-0 · Cited by 274 · see citing works

Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system

Johnson, E., Taniuchi, M., Clark, H., Springer, J., Koh, S., Tayrien, M. W., & Loy, R. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-03-00923.1987 · Cited by 268 · see citing works

A glia‐derived neurite‐promoting factor with protease inhibitory activity.

Guenther, J., Nick, H., & Monard, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03878.x · Cited by 267 · see citing works

The effect of fibroblast growth factor on PC12 cells

Togari, A., Dickens, G., Kuzuya, H., & Guroff, G. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-02-00307.1985 · Cited by 266 · see citing works

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

Fallon, J. H., Seroogy, K. B., Loughlin, S. E., Morrison, R. S., Bradshaw, R. A., Knaver, D. J., & Cunningham, D. D. (1984) · Science · doi:10.1126/science.6144184 · Cited by 262 · see citing works

HYPOTHESES CONCERNED WITH AXONAL REGENERATION IN THE MAMMALIAN NERVOUS SYSTEM

Kiernan, J. A. (1979) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1979.tb00871.x · Cited by 262 · see citing works

Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity

Leong, K. W., D'Amore, P. A., Marletta, M. A., & Langer, R. (1986) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820200106 · Cited by 261 · see citing works

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

Stylianopoulou, F., Herbert, J., Soares, M. B., & Efstratiadis, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.141 · Cited by 258 · see citing works

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Science · doi:10.1126/science.2457949 · Cited by 256 · see citing works

An anatomical study of the development of the septo-hippocampal projection in the rat

Milner, T. A., Loy, R., & Amaral, D. G. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90017-2 · Cited by 254 · see citing works

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

Stemple, D. L., Mahanthappa, N. K., & Anderson, D. J. (1988) · Neuron · doi:10.1016/0896-6273(88)90182-1 · Cited by 252 · see citing works

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

Manthorpe, M., Skaper, S. D., Williams, L. R., & Varon, S. S. (1986) · Brain Research · doi:10.1016/0006-8993(86)91603-3 · Cited by 251 · see citing works

Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria‐fornix transection

Batchelor, P., Armstrong, D. M., Blaker, S. N., & Gage, F. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840204 · Cited by 251 · see citing works

Expression of NGF receptor in the developing and adult primate central nervous system

Schatteman, G., Gibbs, L., Lanahan, A. A., Claude, P., & Bothwell, M. A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00860.1988 · Cited by 251 · see citing works

The response of chick sensory neurons to brain-derived neurotrophic factor

Davies, A. M., Thoenen, H., & Barde, Y. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-07-01897.1986 · Cited by 247 · see citing works

Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

Lillien, L. E., Sendtner, M., Rohrer, H., Hughes, S. M., & RAFF, M. C. (1988) · Neuron · doi:10.1016/0896-6273(88)90179-1 · Cited by 247 · see citing works

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

Lärkfors, L., Ebendal, T., Whittemore, S. R., Persson, H., Hoffer, B. J., & Olson, L. (1987) · Molecular Brain Research · doi:10.1016/0169-328x(87)90044-1 · Cited by 245 · see citing works

Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat

Ernfors, P., Hallböök, F., Ebendal, T., Shooter, E. M., Radeke, M. J., Misko, T. P., & Persson, H. (1988) · Neuron · doi:10.1016/0896-6273(88)90155-9 · Cited by 244 · see citing works

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

Gage, F. H., Batchelor, P., Chen, K. S., Chin, D. E., Higgins, G. A., Koh, S., Deputy, S. R., Rosenberg, M. B., Fischer, W., & Björklund, A. (1989) · Neuron · doi:10.1016/0896-6273(89)90184-0 · Cited by 241 · see citing works

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

DiCicco-Bloom, E. M., & Black, I. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4066 · Cited by 240 · see citing works

The role of NGF in sensory neurons in vivo

Johnson, E. M., Rich, K. M., & Yip, H. K.-F. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90012-3 · Cited by 235 · see citing works

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage

Hagg, T., Manthorpe, M., Vahlsing, H. L., & Varon, S. S. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90013-1 · Cited by 233 · see citing works

Neurotrophic Factors

Thoenen, H., & Edgar, D. (1985) · Science · doi:10.1126/science.2409599 · Cited by 233 · see citing works

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

Gage, F. H., Wictorin, K., Fischer, W., Williams, L. R., Varon, S. S., & Björklund, A. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90018-7 · Cited by 232 · see citing works

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

Lenoir, D., & Honegger, P. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90177-3 · Cited by 231 · see citing works

Glia-Induced Morphological Differentiation in Neuroblastoma Cells

Monard, D., Solomon, F., Rentsch, M., & Gysin, R. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.6.1894 · Cited by 229 · see citing works

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Matsuda, H., Coughlin, M. D., Bienenstock, J., & Denburg, J. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6508 · Cited by 228 · see citing works

Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism

Gage, F. H., & Björklund, A. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02837.1986 · Cited by 223 · see citing works

Specificity of retrograde transport of nerve growth factor (NGF) in sensory neurons: A biochemical and morphological study

Stoeckel, K., Schwab, M. E., & Thoenen, H. (1975) · Brain Research · doi:10.1016/0006-8993(75)90129-8 · Cited by 220 · see citing works

Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons

Gorin, P. D., & Johnson, E. M. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5382 · Cited by 220 · see citing works

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

Montero‐Menei, C. N., & Hefti, F. F. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02986.1988 · Cited by 211 · see citing works

Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor

Oppenheim, R. W., Haverkamp, L. J., Prevette, D. M., McManaman, J. L., & Appel, S. H. (1988) · Science · doi:10.1126/science.3363373 · Cited by 208 · see citing works

Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats

Hatanaka, H., Tsukui, H., & Nihonmatsu, I. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90069-7 · Cited by 208 · see citing works

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

Haselbacher, G. K., Schwab, M. E., Pasi, A., & HUMBEL, R. E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.7.2153 · Cited by 205 · see citing works

Grafting genetically modified cells to the brain: Possibilities for the future

Gage, F. H., Wolff, J. A., Rosenberg, M. B., Xu, L., Yee, J. K., Shults, C. W., & Friedmann, T. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90159-x · Cited by 204 · see citing works

Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.

Lièvre, C. A., Olson, L., Ebendal, T., Hallböök, F., & Persson, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2628 · Cited by 201 · see citing works

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

Bernd, P., & Greene, L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42578-6 · Cited by 197 · see citing works

Some characteristics of histamine secretion from rat peritoneal mast cells stimulated with nerve growth factor.

Pearce, F. L., & Thompson, H. L. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016014 · Cited by 196 · see citing works

Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage

Sofroniew, M. V., Pearson, R. C. A., Eckenstein, F. P., Cuello, A. C., & Powell, T. P. S. (1983) · Brain Research · doi:10.1016/0006-8993(83)90045-8 · Cited by 196 · see citing works

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

Boyd, F. T., Clarke, D. W., Muther, T. F., & Raizada, M. K. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36340-8 · Cited by 194 · see citing works

Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor

Korsching, S. I., & Thoenen, H. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90155-6 · Cited by 194 · see citing works

Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence

Clarke, P. B. S., Hommer, D. W., Pert, A., & Skirboll, L. R. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90176-x · Cited by 191 · see citing works

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

Korsching, S. I., Heumann, R., Thoenen, H., & Hefti, F. F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90186-2 · Cited by 189 · see citing works

Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain

Wilcox, J., & Derynck, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01901.1988 · Cited by 186 · see citing works

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

Cohen, M. L., Golde, T. E., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1227 · Cited by 186 · see citing works

In vivo effect of brain‐derived neurotrophic factor on the survival of developing dorsal root ganglion cells.

Kalcheim, C., Barde, Y., Thoenen, H., & Douarin, N. M. L. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02589.x · Cited by 183 · see citing works

Insulin-Mediated Regulation of Neuronal Maturation

Puro, D. G., & Agardh, E. (1984) · Science · doi:10.1126/science.6089343 · Cited by 181 · see citing works

Loss of pedunculopontine neurons in progressive supranuclear palsy

Zweig, R. M., Whitehouse, P. J., Casanova, M. F., Walker, L. C., Januarykel, W. R., & Price, D. L. (1987) · Annals of Neurology · doi:10.1002/ana.410220107 · Cited by 180 · see citing works

Is Alzheimer disease caused by lack of nerve growth factor?

Hefti, F. F. (1983) · Annals of Neurology · doi:10.1002/ana.410130127 · Cited by 179 · see citing works

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

Nieto‐Sampedro, M., & Berman, M. A. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170303 · Cited by 177 · see citing works

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

Bohannon, N. J. V., Wilcox, B. J., Figlewicz, D. P., Dorsa, D. M., & Baskin, D. G. (1988) · Brain Research · doi:10.1016/0006-8993(88)90931-6 · Cited by 177 · see citing works

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

Mill, J. F., Chao, M. V., & Ishii, D. N. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7126 · Cited by 177 · see citing works

Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes

Kordower, J. H., Bartus, R. T., Bothwell, M., Schatteman, G. C., & Gash, D. M. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770402 · Cited by 174 · see citing works

Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor.

Taniuchi, M., & Johnson, E. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.1100 · Cited by 173 · see citing works

Potential use of nerve growth factor to treat Alzheimer's disease

Phelps, C. H., Gage, F. H., Growdon, J. H., Hefti, F. F., Harbaugh, R. E., Johnston, M. V., Khachaturian, Z. S., Mobley, W. C., Price, D. L., Raskind, M. A., et al. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90032-8 · Cited by 172 · see citing works

Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions

Will, B. E., & Hefti, F. F. (1985) · Behavioural Brain Research · doi:10.1016/0166-4328(85)90004-x · Cited by 171 · see citing works

Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease

Hefti, F. F., & Mash, D. C. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80014-4 · Cited by 169 · see citing works

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs

Schwartz, J. P., Pearson, J. M., & Johnson, E. M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90102-0 · Cited by 163 · see citing works

Nerve Growth Factor: Biological Significance, Measurement and Distribution

Harper, G., & Thoenen, H. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb04615.x · Cited by 163 · see citing works

Senile plaques as aberrant sprout-stimulating structures

Geddes, J. W., Anderson, K. J., & Cotman, C. W. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90254-2 · Cited by 161 · see citing works

The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration

Sofroniew, M. V., Pearson, R. C. A., & Powell, T. P. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)91084-5 · Cited by 161 · see citing works

A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

Green, S. H., & Greene, L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66870-x · Cited by 157 · see citing works

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

Walicke, P. A., & Baird, A. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90009-0 · Cited by 156 · see citing works

Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

Buck, C. R., Martínez, H., Black, I. B., & Chao, M. V. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.3060 · Cited by 155 · see citing works

Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture

Dohrmann, U., Edgar, D., Sendtner, M., & Thoenen, H. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90089-8 · Cited by 154 · see citing works

Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase

Auburger, G. W. J., Heumann, R., Hellweg, R., Korsching, S. I., & Thoenen, H. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90235-1 · Cited by 154 · see citing works

Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury

Stein, D. G., & Sabel, B. A. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0927-7 · Cited by 153 · see citing works

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury

Rich, K. M., Yip, H. K.-F., Osborne, P. A., Schmidt, R. E., & Johnson, E. M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902300110 · Cited by 153 · see citing works

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

Van, Q., Snider, W. D., Pinzone, J. J., & Johnson, E. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90082-7 · Cited by 152 · see citing works

Stabilizing basic fibroblast growth factor using protein engineering

Seno, M., Sasada, R., Iwane, M., Sudo, K., Kurokawa, T., Ito, K., & Igarashi, K. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80337-1 · Cited by 150 · see citing works

Experimental approaches to age-related cognitive impairments

Gage, F. H., Chen, K. S., Buzsáki, G., & Armstrong, D. L. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80129-5 · Cited by 149 · see citing works

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

Morrison, R. S., Keating, R. F., & Moskal, J. R. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210111 · Cited by 147 · see citing works

The effect of platelet-derived growth factor on morphology and motility of human glial cells

Mellstr�m, K., H�glund, A.-S., Nist�r, M., Heldin, C., Westermark, B., & Lindberg, U. (1983) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf00712117 · Cited by 144 · see citing works

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

Rodrı́guez-Tébar, A., & Barde, Y. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03337.1988 · Cited by 142 · see citing works

Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium

Giller, E. L., Neale, J., Bullock, P. N., Schrier, B. K., & Nelson, P. G. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.16 · Cited by 140 · see citing works

Insulin‐like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase.

Ballotti, R., Nielsen, F. C., Pringle, N. P., Kowalski‐Chauvel, A., Richardson, W. D., OBBERGHEN, E. V., & Gammeltoft, S. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02695.x · Cited by 140 · see citing works

Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells.

Henderson, C. E., Huchet, M., & Changeux, J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2625 · Cited by 139 · see citing works

Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain

Crutcher, K. A. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90013-0 · Cited by 138 · see citing works

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.

Komoriya, A., Hortsch, M., Meyers, C. A., Smith, M. J., Kanety, H., & Schlessinger, J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1351 · Cited by 135 · see citing works

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF)

Toso, R. D., Giorgi, O., Soranzo, C., Kirschner, G., Ferrari, G. V. D., Favaron, M., Benvegnú, D. M., Presti, D. L., Vicini, S., & Toffano, G. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00733.1988 · Cited by 134 · see citing works

Extracts of Skeletal Muscle Increase Neurite Outgrowth and Cholinergic Activity of Fetal Rat Spinal Motor Neurons

Smith, R. G., & Appel, S. H. (1983) · Science · doi:10.1126/science.6823568 · Cited by 133 · see citing works

Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.

Moscatelli, D., Joseph‐Silverstein, J., Manejias, R. E., & Rifkin, D. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5778 · Cited by 132 · see citing works

A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity

Underwood, A. H., Emmett, J. C., Ellis, D. A., Flynn, S. B., Leeson, P. D., Benson, G. M., Novelli, R., Pearce, N. J., & Shah, V. P. (1986) · Nature · doi:10.1038/324425a0 · Cited by 132 · see citing works

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

Burgess, S. K., Jacobs, S., Cuatrecasas, P., & Sahyoun, N. E. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75681-6 · Cited by 131 · see citing works

Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.

Wagner, J. A., & D'Amore, P. A. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.4.1363 · Cited by 131 · see citing works

Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord

Eckenstein, F. P. (1988) · Brain Research · doi:10.1016/0006-8993(88)91305-4 · Cited by 130 · see citing works

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

Binoux, M., Hossenlopp, P., LASSARRE, C., & Hardouin, N. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80131-7 · Cited by 130 · see citing works

Neurotrophins: Roles in Neuronal Development and Function

Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

Crowley, C. W., Spencer, S. D., Nishimura, M. C., Chen, K. S., Pitts-Meek, S., Armaninl, M. P., Ling, L. H., McMahon, S. B., Shelton, D. L., Levinson, A. D., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90378-6 · Cited by 1,068 · see citing works

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921 · see citing works

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works

On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis

Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829 · see citing works

The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments

Schwarting, R. K. W., & Huston, J. P. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00040-8 · Cited by 741 · see citing works

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

Cheng, B., Christakos, S., & Mattson, M. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90159-7 · Cited by 669 · see citing works

The nerve growth factor family of receptors

Meakin, S. O., & Shooter, E. M. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90047-c · Cited by 657 · see citing works

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

Knüsel, B., Winslow, J. W., Rosenthal, A., Burton, L. E., Seid, D. P., Nikolics, K., & Hefti, F. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.961 · Cited by 603 · see citing works

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

Mufson, E. J., Counts, S., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 589 · see citing works

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

PHILLIPS, H. S., Hains, J. M., Laramee, G. R., Rosenthal, A., & Winslow, J. W. (1990) · Science · doi:10.1126/science.1688328 · Cited by 532 · see citing works

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

Knüsel, B., Michel, P. P., Schwaber, J. S., & Hefti, F. F. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00558.1990 · Cited by 521 · see citing works

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

Mamounas, L., Blue, M., Siuciak, J. A., & Altar, C. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07929.1995 · Cited by 471 · see citing works

Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease

Jönhagen, M. E., Nordberg, A. K., Amberla, K., Bäckman, L., Ebendal, T., Meyerson, B. A., Olson, L., Seiger, Å., Shigeta, M., Theodorsson, E., et al. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017069 · Cited by 472 · see citing works

Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine1

WANG, R., YAN, H., & TANG, X.-C. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00255.x · Cited by 470 · see citing works

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

Cheng, B., & Mattson, M. P. (1991) · Neuron · doi:10.1016/0896-6273(91)90347-3 · Cited by 462 · see citing works

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

Spina, M. B., Squinto, S. P., Miller, J. M., Lindsay, R. M., & Hyman, C. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08880.x · Cited by 460 · see citing works

The Role of Inflammation and Cytokines in Brain Injury

Arvin, B. M., Neville, L. F., Barone, F. C., & Feuerstein, G. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00026-7 · Cited by 417 · see citing works

The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

Petty, B. G., Cornblath, D. R., Adornato, B. T., Chaudhry, V., Flexner, C. W., Wachsman, M., Sinicropi, D. V., Burton, L. E., & Peroutka, S. J. (1994) · Annals of Neurology · doi:10.1002/ana.410360221 · Cited by 402 · see citing works

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

Cheng, B., & Mattson, M. P. (1994) · Brain Research · doi:10.1016/0006-8993(94)91857-0 · Cited by 395 · see citing works

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

Mattson, M. P., Tomaselli, K. J., & Rydel, R. E. (1993) · Brain Research · doi:10.1016/0006-8993(93)90295-x · Cited by 379 · see citing works

Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury.

Dougherty, K. D., Dreyfus, C., & Black, I. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0318 · Cited by 373 · see citing works

Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson’s disease in rats

Mandel, R. J., Spratt, S. K., Snyder, R. O., & Leff, S. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14083 · Cited by 328 · see citing works

Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

Ip, N. Y., Li, Y., Yancopoulos, G. D., & Lindsay, R. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03394.1993 · Cited by 331 · see citing works

TrkA‐immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin

Sobreviela, T., Clary, D. O., Reichardt, L. F., Brandabur, M. M., Kordower, J. H., & Mufson, E. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500407 · Cited by 326 · see citing works

Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy

Mattson, M. P., & Scheff, S. W. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.3 · Cited by 308 · see citing works

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

Engele, J., & Bohn, M. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03070.1991 · Cited by 304 · see citing works

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.

Perry, T., Lahiri, D., Chen, D., Zhou, J., Shaw, K., Egan, J., & Greig, N. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.958 · Cited by 306 · see citing works

Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

Mufson, E. J., Kroin, J. S., Sendera, T. J., & Sobreviela, T. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00059-8 · Cited by 296 · see citing works

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

Knüsel, B., Beck, K., Winslow, J. W., Rosenthal, A., Burton, L., Widmer, H., Nikolics, K., & Hefti, F. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04391.1992 · Cited by 278 · see citing works

Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo

Konishi, Y., Chui, D., Hirose, H., Kunishita, T., & Tabira, T. (1993) · Brain Research · doi:10.1016/0006-8993(93)90850-m · Cited by 273 · see citing works

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

Scott, S. A., Mufson, E. J., Weingartner, J. A., Skau, K., & Crutcher, K. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06213.1995 · Cited by 264 · see citing works

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

Cheng, B., & Mattson, M. P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01558.1992 · Cited by 254 · see citing works

Neurotrophic factor therapy for nervous system degenerative diseases

Hefti, F. F. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251109 · Cited by 251 · see citing works

K‐252 Compounds: Modulators of Neurotrophin Signal Transduction

Knüsel, B., & Hefti, F. F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10085.x · Cited by 244 · see citing works

Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.

Hagg, T., & Varon, S. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6315 · Cited by 229 · see citing works

Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits

Chen, K. S., Nishimura, M. C., Armanini, M. P., Crowley, C. W., Spencer, S. D., & PHILLIPS, H. S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07288.1997 · Cited by 227 · see citing works

Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis

Mufson, E., Conner, J., & Kordower, J. (1995) · NeuroReport · doi:10.1097/00001756-199505090-00028 · Cited by 221 · see citing works

The Role of Nerve Growth Factor Receptors in Cholinergic Basal Forebrain Degeneration in Prodromal Alzheimer Disease

Counts, S., & Mufson, E. J. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.4.263 · Cited by 222 · see citing works

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

Li, Y., Holtzman, D. M., Kromer, L., Kaplan, D., Chua-Couzens, J., Clary, D. O., Knüsel, B., & Mobley, W. C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02888.1995 · Cited by 220 · see citing works

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

Hagg, T., Quon, D. H., Higaki, J. N., & Varon, S. S. (1992) · Neuron · doi:10.1016/0896-6273(92)90116-u · Cited by 211 · see citing works

Delivery of 125 I-NGF to the Brain via the Olfactory Route

Frey, W. H., Liu, J., Chen, X., Thorne, R. G., Fawcett, J. R., Ala, T. A., & Rahman, Y. (1997) · Drug Delivery · doi:10.3109/10717549709051878 · Cited by 210 · see citing works

β-Amyloid and the Pathogenesis of Alzheimer's Disease

Flier, J. S., Underhill, L. H., Yankner, B. A., & Mesulam, M. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112263252605 · Cited by 207 · see citing works

Distribution of nerve growth factor following direct delivery to brain interstitium

Krewson, C. E., Klarman, M. L., & Saltzman, W. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00261-n · Cited by 201 · see citing works

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

Knüsel, B., Rabin, S. L., Hefti, F. F., & Kaplan, D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01542.1994 · Cited by 202 · see citing works

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

Federoff, H. J., Geschwind, M. D., Geller, A. I., & Kessler, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1636 · Cited by 198 · see citing works

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

Mattson, M. P., Kumar, K. N., Wang, H., Cheng, B., & Michaelis, E. K. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04575.1993 · Cited by 195 · see citing works

Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors

Araujo, D., & Cotman, C. W. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01668.1992 · Cited by 193 · see citing works

Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

Mufson, E. J., & Kordower, J. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.569 · Cited by 190 · see citing works

PHARMACOLOGY OF NEUROTROPHIC FACTORS

Hefti, F. F. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.239 · Cited by 186 · see citing works

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

Tuszynski, M. H., Hoi Sang, U., Yoshida, K., & Gage, F. H. (1991) · Annals of Neurology · doi:10.1002/ana.410300502 · Cited by 183 · see citing works

Brain α‐Ketoglutarate Dehydrotenase Complex Activity in Alzheimer's Disease

Mastrogiacomo, F., Bergeron, C., & Kish, S. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07436.x · Cited by 176 · see citing works

The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth FACTOR-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture

Beck, K. D., Knüsel, B., & Hefti, F. F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90534-m · Cited by 176 · see citing works

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

Yankner, B. A., Cáceres, A., & Duffy, L. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.9020 · Cited by 171 · see citing works

Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine

Martin-Iverson, M. T., Todd, K. G., & Altar, C. A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01262.1994 · Cited by 170 · see citing works

Astroglial neurotrophic and neurite-promoting factors

Müller, H. W. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00047-7 · Cited by 167 · see citing works

Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF

Williams, E. J., Furness, J., Walsh, F. S., & Doherty, P. (1994) · Development · doi:10.1242/dev.120.6.1685 · Cited by 161 · see citing works

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

Mitra, S., Behbahani, H., & Eriksdotter, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00038 · Cited by 159 · see citing works

Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise.

Mattson, M. P. (1994) · PubMed · Cited by 154 · see citing works

Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain

Oyesiku, N. M., Evans, C.-O., Houston, S., Darrell, R. S., Smith, J. S., Fulop, Z. L., Dixon, C. E., & Stein, D. G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01501-2 · Cited by 153 · see citing works

Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: Role of mesencephalic glia

Engele, J., Schubert, D. A., & Bohn, M. C. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490300212 · Cited by 150 · see citing works

Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.

Eves, E. M., Tucker, M. S., Roback, J. D., Downen, M., Rosner, M. R., & Wainer, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4373 · Cited by 149 · see citing works

Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type

Tham, A., Nordberg, A. K., Grissom, F. E., Carlsson‐Skwirut, C., Viitanen, M. H., & Sara, V. R. (1993) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02257671 · Cited by 144 · see citing works

Is There a Role for Estrogen Replacement Therapy in the Prevention and Treatment of Dementia?

Birge, S. J. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb03749.x · Cited by 140 · see citing works

Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: Compensatory response to neurotoxin‐induced cell death in the adult rat brain

Fritschy, J., & Grzanna, R. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903210309 · Cited by 138 · see citing works

Calcium and Neuronal Injury in Alzheimer's Disease

Mattson, M. P. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44401.x · Cited by 164 · see citing works

Reversible schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor

Winkler, J., Ramirez, G. A., Kuhn, H. G., Peterson, D. A., Day-Lollini, P. A., Stewart, G. R., Tuszynski, M. H., Gage, F. H., & Thal, L. J. (1997) · Annals of Neurology · doi:10.1002/ana.410410114 · Cited by 138 · see citing works

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

Cheng, B., & Mattson, M. P. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90120-f · Cited by 137 · see citing works

Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

Lundberg, C., Björklund, T., Carlsson, T., Jakobsson, J., Hantraye, P., Déglon, N., & Kirik, D. (2008) · Current Gene Therapy · doi:10.2174/156652308786847996 · Cited by 133 · see citing works

Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture

O'Malley, E. K., Sieber, B.-A., Black, I. B., & Dreyfus, C. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90317-3 · Cited by 129 · see citing works

ProNGF and Neurodegeneration in Alzheimer’s Disease

Fahnestock, M. L., & Shekari, A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00129 · Cited by 126 · see citing works

Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010) · Biomedical Research · doi:10.2220/biomedres.31.231 · Cited by 125 · see citing works

Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis

Evercooren, A. B., Olichon‐Berthe, C., Kowalski‐Chauvel, A., Visciano, G., & OBBERGHEN, E. V. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280212 · Cited by 124 · see citing works

Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise

Duman, C. H., Schlesinger, L., Terwilliger, R., Russell, D. S., Newton, S. S., & Duman, R. S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.016 · Cited by 123 · see citing works

Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats

Shimbo, M., Kawagishi, H., & Yokogoshi, H. (2005) · Nutrition Research · doi:10.1016/j.nutres.2005.06.001 · Cited by 119 · see citing works

Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine‐mediated calcium dyshomeostasis

Landfield, P. W., Thibault, O., Mazzanti, M. L., Porter, N. M., & Kerr, D. S. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230914 · Cited by 118 · see citing works

Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease.

Kordower, J. H., Charles, V., Bayer, R. A., Bartus, R. T., Putney, S. D., Walus, L. R., & Friden, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9077 · Cited by 116 · see citing works

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

Lapchak, P. A., Araujo, D. M., Quirion, R., & Beaudet, A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90259-q · Cited by 113 · see citing works

THE FIMBRIA-FORNIX/CINGULAR BUNDLE PATHWAYS: A REVIEW OF NEUROCHEMICAL AND BEHAVIOURAL APPROACHES USING LESIONS AND TRANSPLANTATION TECHNIQUES

Cassel, J., Duconseille, E., Jeltsch‐David, H., & Will, B. E. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00009-9 · Cited by 110 · see citing works

Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion

Chen, K. S., Masliah, E., Mallory, M. E., & Gage, F. H. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00099-5 · Cited by 111 · see citing works

Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examplesa

Mattson, M. P., Rydel, R. E., Lieberburg, I. M., & Smith‐Swintosky, V. L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18285.x · Cited by 110 · see citing works

Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia.

Siliprandi, R., Canella, R., & Carmignoto, G. (1993) · PubMed · Cited by 109 · see citing works

Neural input regulates tissue NGF and growth of the adult rat urinary bladder

Tuttle, J. B., Steers, W. D., Albo, M., & Nataluk, E. A. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90134-1 · Cited by 109 · see citing works

Region- and peptide-specific regulation of the neurotrophins by estrogen

Jezierski, M., & Sohrabji, F. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00244-8 · Cited by 108 · see citing works

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator

Legutko, B., Li, X., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00006-5 · Cited by 106 · see citing works

BDNF and trkB mRNA expression in the hippocampal formation of aging rats

Lapchak, P. A., Araujo, D. M., Beck, K. D., Finch, C. E., Johnson, S. A., & Hefti, F. F. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90087-r · Cited by 105 · see citing works

Cholinotrophic Molecular Substrates of Mild Cognitive Impairment in the Elderly

Mufson, E. J., Counts, S., Fahnestock, M. L., & Ginsberg, S. D. (2007) · Current Alzheimer Research · doi:10.2174/156720507781788855 · Cited by 100 · see citing works

Effects of nerve growth factor on neuronal plasticity of the kitten visual cortex.

Carmignoto, G., Canella, R., Candeo, P., Comelli, M. C., & Maffei, L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019638 · Cited by 105 · see citing works

Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat

Martin, D., Miller, G., Rosendahl, M. S., & Russell, D. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00369-2 · Cited by 104 · see citing works

Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease

Mufson, E., Li, J.-M., Sobreviela, T., & Kordower, J. (1996) · NeuroReport · doi:10.1097/00001756-199612200-00006 · Cited by 100 · see citing works

Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats

Rylett, R. J., Goddard, S., Schmidt, B., & Williams, L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03956.1993 · Cited by 101 · see citing works

NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion

Hoffman–Kim, D., Wahlberg, L. U., & Aebischer, P. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90049-x · Cited by 101 · see citing works

Transport and elimination of recombinant human NGF during long-term delivery to the brain

Krewson, C. E., & Saltzman, W. M. (1996) · Brain Research · doi:10.1016/0006-8993(96)00378-2 · Cited by 99 · see citing works

Receptor‐mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors

Ferguson, I. A., Schweitzer, J. B., Bartlett, P. F., & Johnson, E. M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130411 · Cited by 100 · see citing works

Modulation of calcium current, intracellular calcium levels and cell survival by glucose deprivation and growth factors in hippocampal neurons

Cheng, B., McMahon, D. G., & Mattson, M. P. (1993) · Brain Research · doi:10.1016/0006-8993(93)91517-v · Cited by 100 · see citing works

Beneficial Effects of Spirulina Consumption on Brain Health

Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98 · see citing works

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?

Bartus, R. T., & Johnson, E. M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.027 · Cited by 97 · see citing works

Herpes Simplex Virus Type 1 Vector-Mediated Expression of Nerve Growth Factor Protects Dorsal Root Ganglion Neurons from Peroxide Toxicity

Goins, W. F., Lee, K. A., Cavalcoli, J. D., O’Malley, M. E., DeKosky, S. T., Fink, D. J., & Glorioso, J. C. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.519-532.1999 · Cited by 95 · see citing works

Estrogen receptor immunoreactivity within subregions of the rat forebrain: neuronal distribution and association with perikarya containing choline acetyltransferase

Mufson, E. J., Cai, W. J., Jaffar, S., Chen, E., Stebbins, G. T., Sendera, T. J., & Kordower, J. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01960-5 · Cited by 96 · see citing works

Neurotrophic Factors and Neurodegenerative Diseases

Hefti, F. F., & Knüsel, B. (1991) · Springer eBooks · doi:10.1007/978-3-642-46722-6_1 · Cited by 5 · see citing works

Neurotrophic factor-based pharmacological approaches in neurological disorders

Castelli, V., Alfonsetti, M., & d’Angelo, M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.358619 · Cited by 30 · see citing works

Neurotrophic factors in the aging brain

PEPEU, G., PUGLIESE, A. M., & BALLERINI, L. (1991) · ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)

Neurotrophic factors in aging brain: a review

Pepeu, G., PUGLIESE, A. M., & L., B. (1991) · Florence Research (University of Florence) · Cited by 1 · see citing works

Neurotrophic factor therapy for nervous system degenerative diseases

Hefti, F. F. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251109 · Cited by 251 · see citing works