The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
Open accessAbstract
The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (RGC) terminals that occurs whenever two retinas innervate one tectal lobe. Exposure of the tectum to the active isomer of APV produces desegregation of the RGC terminals without blocking electrical activity in the afferents or altering their terminal arbor morphology. Exposure to the inactive isomer of APV causes no perturbation of the normal stripe pattern. APV-induced desegregation is completely reversible within 2 weeks of removal of the APV. In addition, exposure of the optic tectum to NMDA results in stripes with sharper borders and fewer forks and fusions than untreated animals. These results suggest that the NMDA receptor/channel plays a role in eye-specific segregation in the three-eyed tadpole.
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Excitatory Amino Acid Transmitters
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Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors
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A Physiological Mechanism for Hebb's Postulate of Learning
Stent, G. S. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.4.997 · Cited by 710
Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex
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Glutamate activates multiple single channel conductances in hippocampal neurons
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Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
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Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission
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Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
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Self-citationStructure, Function, and Pharmacology of Glutamate Receptor Ion Channels
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Metadata
- Authors
- Cline, H. T., Debski, E. A., & Constantine-Paton, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-06
- Volume
- 84
- Issue
- 12
- Pages
- 4342-4345
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969492805
- Cited by
- 527
- References
- 35
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Cline, H. T., Debski, E. A., & Constantine-Paton, M. (1987). N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.12.4342
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
