The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding

INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS

Elbein, A. D. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002433 · Cited by 1,126 · see citing works

Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

Moore, J., McKeating, J., Weiss, R., & Sattentau, Q. (1990) · Science · doi:10.1126/science.2251501 · Cited by 625 · see citing works

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

McCune, J. M., Rabin, L. B., Feinberg, M. B., Lieberman, M., Kosek, J. C., Reyes, G. R., & Weissman, I. L. (1988) · Cell · doi:10.1016/0092-8674(88)90487-4 · Cited by 610 · see citing works

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

Gruters, R. A., Neefjes, J., Tersmette, M., de Goede, R. E. Y., Tulp, A., Huisman, H. G., Miedema, F. F., & Ploegh, H. L. (1987) · Nature · doi:10.1038/330074a0 · Cited by 578 · see citing works

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160

Willey, R. L., Bonifacino, J. S., Potts, B. J., Martin, M. A., & Klausner, R. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9580 · Cited by 428 · see citing works

Inhibition of HIV replication by amino‐sugar derivatives

Fleet, G. W. J., Karpas, A., Dwek, R. A., Fellows, L. E., Tyms, A. S., Petursson, S., Namgoong, S. K., Ramsden, N. G., Smith, P. W., Son, J. C., et al. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80185-6 · Cited by 349 · see citing works

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

Karpas, A., Fleet, G. W. J., Dwek, R. A., Petursson, S., Namgoong, S. K., Ramsden, N. G., Jacob, G. S., & Rademacher, T. W. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9229 · Cited by 339 · see citing works

Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.

Walker, B. D., Kowalski, M. M., Goh, W. C., Kozarsky, K., Krieger, M., Rosen, C. A., Rohrschneider, L. R., Haseltine, W. A., & Sodroski, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8120 · Cited by 337 · see citing works

Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases

Saunier, B., Kilker, R. D., Tkacz, J. S., Quaroni, A., & Herscovics, A. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45358-1 · Cited by 283 · see citing works

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

McKeating, J. A., McKnight, Á., & Moore, J. P. (1991) · Journal of Virology · doi:10.1128/jvi.65.2.852-860.1991 · Cited by 228 · see citing works

Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

Montefiori, D. C., Robinson, W. E., & Mitchell, W. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9248 · Cited by 188 · see citing works

Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.

Block, T. M., Lu, X., Platt, F. M., Foster, G. R., Gerlich, W. H., Blumberg, B. S., & Dwek, R. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2235 · Cited by 186 · see citing works

Golgi endo-alpha-D-mannosidase from rat liver, a novel N-linked carbohydrate unit processing enzyme.

Lubas, W. A., & Spiro, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61422-x · Cited by 180 · see citing works

Viral Fusion Mechanisms

Jones, I. M. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90074-w · Cited by 178 · see citing works

Effects of the imino sugar N-butyldeoxynojirimycin on the N-glycosylation of recombinant gp120.

Karlsson, G. B., Butters, T. D., Dwek, R. A., & Platt, F. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54189-2 · Cited by 173 · see citing works

Evaluation of the role of rat liver Golgi endo-alpha-D-mannosidase in processing N-linked oligosaccharides.

Lubas, W. A., & Spiro, R. G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69024-6 · Cited by 151 · see citing works

Demonstration that Golgi endo-alpha-D-mannosidase provides a glucosidase-independent pathway for the formation of complex N-linked oligosaccharides of glycoproteins.

Moore, S. E. H., & Spiro, R. G. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38272-9 · Cited by 147 · see citing works

1-deoxynojirimycin impairs oligosaccharide processing of alpha 1-proteinase inhibitor and inhibits its secretion in primary cultures of rat hepatocytes.

Gross, V., Andus, T., Tran-Thi, T. A., Schwarz, R. Τ., Decker, K., & Heinrich, P. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44157-3 · Cited by 122 · see citing works

Characterization of recombinant gp120 and gp160 from HIV-1

Moore, J. P., McKeating, J. A., Jones, I. M., et al. (1990) · AIDS · doi:10.1097/00002030-199004000-00004 · Cited by 116 · see citing works

High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.

Davis, S. J., Ward, H. A., Puklavec, M. J., Willis, A. C., Williams, A., & Barclay, A. N. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86961-7 · Cited by 115 · see citing works

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

Pal, R., Hoke, G., & Sarngadharan, M. G. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3384 · Cited by 104 · see citing works

Inhibition of HIV and SIV infectivity by blockade of α-glucosidase activity

Ratner, L., Heyden, N. V., & Dedera, D. A. (1991) · Virology · doi:10.1016/0042-6822(91)90483-r · Cited by 103 · see citing works

Detection of receptor-ligand interactions using surface plasmon resonance: Model studies employing the HIV-1 gp120/CD4 interaction

Brigham-Burke, M. R., Edwards, J. R., & O'Shannessy, D. J. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90588-x · Cited by 80 · see citing works

The Kinetics of Human Immunodeficiency Virus Reverse Transcription Are Slower in Primary Human Macrophages Than in a Lymphoid Cell Line

Collin, M., & Gordon, S. (1994) · Virology · doi:10.1006/viro.1994.1169 · Cited by 68 · see citing works

Chemical modification of the glucosidase inhibitor 1-deoxynojirimycin. Structure-activity relationships

Tan, A. K., van den Broek, L. A. M., van Boeckel, S., Ploegh, H. L., & Bolscher, J. G. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98715-6 · Cited by 67 · see citing works

The effects of inhibitors of glucosidase I on the formation of Sindbis virus

Schlesinger, S., Koyama, A. H., Malfer, C., Gee, S. L., & Schlesinger, M. J. (1985) · Virus Research · doi:10.1016/0168-1702(85)90244-8 · Cited by 61 · see citing works

The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles.

Repp, R., Tamura, T., Boschek, C. B., et al. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36339-1 · Cited by 56 · see citing works

Nonselective utilization of the endomannosidase pathway for processing glycoproteins by human hepatoma (HepG2) cells.

Rabouille, C., & Spiro, R. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49949-3 · Cited by 54 · see citing works

Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells

Taylor, D. L., Kang, M. S., Brennan, T., BRIDGES, C. G., Sunkara, P. S., & Tyms, A. S. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.8.1780 · Cited by 47 · see citing works

Studies with inhibitors of oligosaccharide processing indicate a functional role for complex sugars in the transport and proteolysis of friend mink cell focus-inducing murine leukemia virus envelope proteins

Pinter, A., Honnen, W. J., & Li, J. S. (1984) · Virology · doi:10.1016/0042-6822(84)90259-9 · Cited by 44 · see citing works

Attenuation of HIV-1 Infectivity by an Inhibitor of Oligosaccharide Processing

Dedera, D. A., Heyden, N. V., & Ratner, L. (1990) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1990.6.785 · Cited by 40 · see citing works

On the role of oligosaccharide trimming in the maturation of sindbis and influenza virus

DATEMA, R., Romero, P. A., ROTT, R., & Schwarz, R. Τ. (1984) · Archives of Virology · doi:10.1007/bf01309294 · Cited by 38 · see citing works

A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.

Simon, J. H., Somoza, C., Schockmel, G. A., Collin, M., Davis, S. J., Williams, A., & James, W. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.4.949 · Cited by 32 · see citing works

Anti-HIV drug mechanism

Jones, I. M., & Jacob, G. S. (1991) · Nature · doi:10.1038/352198b0 · Cited by 31 · see citing works

Mechanism of Action of N -Butyl Deoxynojirimycin in Inhibiting HIV-1 Infection and Activity in Combination with Nucleoside Analogs

Ratner, L., & Heyden, N. V. (1993) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1993.9.291 · Cited by 28 · see citing works

Inhibitors Of The Biosynthesis And Processing Of N-Linked Oligosaccharide Chains

Elbein, A. D. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.56.1.497 · Cited by 26 · see citing works

Biochemical characterization of cell-associated and extracellular products of the friend spleen focus-forming virus env gene

Pinter, A., & Honnen, W. J. (1989) · Virology · doi:10.1016/0042-6822(89)90229-8 · Cited by 21 · see citing works

Asparagine-linked oligosaccharides of BHK cells treated with inhibitors of oligosaccharide processing

Hughes, R. C., Foddy, L., & Bause, E. (1987) · Biochemical Journal · doi:10.1042/bj2470537 · Cited by 21 · see citing works

Development of techniques to analyse the formation of HIV provirus in primary human macrophages

Collin, M., James, W., & Gordon, S. (1991) · Research in Virology · doi:10.1016/0923-2516(91)90045-5 · Cited by 20 · see citing works

PCR analysis of HIV1 infection of macrophages: virus entry is CD4-dependent

Collin, M., Herbein, G., Montaner, L. J., et al. (1993) · Research in Virology · doi:10.1016/s0923-2516(06)80006-3 · Cited by 18 · see citing works

Assembly of asparagine‐linked oligosaccharides in baby hamster kidney cells treated with castanospermine, an inhibitor of processing glucosidases

Foddy, L., & Hughes, R. C. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14196.x · Cited by 17 · see citing works

HIV-1 pseudotype virus containing a Cocal virus genome and an HIV envelope: construction, assay and use

Gregory, S. A., Collman, R. G., James, W., et al. (1993) · Journal of Virological Methods · doi:10.1016/0166-0934(93)90064-x · Cited by 11 · see citing works

Aminosugar derivatives as potential anti-human immunodeficiency virus agents

(1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5625-b · Cited by 10 · see citing works

Polyhydroxylated alkaloids—Natural occurrence and therapeutic applications

Watson, A. A., Fleet, G. W. J., Asano, N., Molyneux, R. J., & Nash, R. J. (2001) · Phytochemistry · doi:10.1016/s0031-9422(00)00451-9 · Cited by 714 · see citing works

Antiviral effects of an iminosugar derivative on flavivirus infections

Wu, S.-F., Lee, C.-J., Liao, C.-L., Dwek, R. A., Zitzmann, N., & Lin, Y.-L. (2002) · Journal of Virology · doi:10.1128/jvi.76.8.3596-3604.2002 · Cited by 220 · see citing works

The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo

Pelletier, M. F., Marcil, A., Sevigny, G., Jakob, C. A., Tessier, D. C., Chevet, E., Menard, R., Bergeron, J. J. M., & Thomas, D. Y. (2000) · Glycobiology · doi:10.1093/glycob/10.8.815 · Cited by 123 · see citing works

1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

Gao, K., Zheng, C., Wang, T., Zhao, H., Wang, J., Wang, Z., Zhai, X., Jia, Z., Chen, J., Zhou, Y., et al. (2016) · Molecules · doi:10.3390/molecules21111600 · Cited by 91 · see citing works

Therapeutic applications of iminosugars: Current perspectives and future opportunities

Horne, G., & Wilson, F. X. (2011) · Progress in medicinal chemistry · doi:10.1016/b978-0-12-381290-2.00004-5 · Cited by 87 · see citing works

Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents

Chang, J., Guo, J.-T., Du, Y., & Block, T. (2013) · Emerging Microbes & Infections · doi:10.1038/emi.2013.77 · Cited by 22 · see citing works

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20 · see citing works

Mutational Analysis of Conserved Domains within the Cytoplasmic Tail of gp41 from Human Immunodeficiency Virus Type 1: Effects on Glycoprotein Incorporation and Infectivity

Piller, S., Dubay, J., Derdeyn, C. A., & Hunter, E. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11717-11723.2000 · Cited by 74 · see citing works

HIV-1 gp41: mediator of fusion and target for inhibition.

Weiss, C. D. (2003) · PubMed · Cited by 86 · see citing works

Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein

Joshi, V. R., Newman, R. M., Pack, M. L., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008577 · Cited by 5 · see citing works

D102 Molecular structures of trimeric HIV-1 and SIV envelope glycoproteins

Subramaniam, S. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000429229.77006.c3

Receptor activated conformations of the gp120-gp41 glycoprotein complex of HIV-1

Bellamy-McIntyre, A. K. (2017) · Figshare · doi:10.4225/03/58a6757fd9907