The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.
Open accessAbstract
Antisense oligonucleotides represent an interesting tool for selective inhibition of gene expression, but their efficient introduction within intact cells proved to be difficult to realize. As a step toward this goal, small (13- or 15-mer) synthetic oligodeoxyribonucleotides have been coupled at their 3' ends to epsilon-amino groups of lysine residues of poly(L-lysine) (Mr, 14,000). A 15-mer oligonucleotide-poly(L-lysine) conjugate complementary to the initiation region of vesicular stomatitis virus (VSV) N-protein mRNA specifically inhibits the synthesis of VSV proteins and exerts an antiviral activity against VSV when added in the cell culture medium at doses as low as 100 nM. Neither synthesis of cellular proteins nor multiplication of encephalomyocarditis virus was affected significantly by this oligonucleotide conjugate. The data suggest that oligonucleotide-poly(L-lysine) conjugates might become effective for studies on gene expression regulation and for antiviral chemotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography
LASKEY, R. A., & MILLS, A. D. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb02238.x · Cited by 4,646
Nucleotide sequence of the rightward operator of phage lambda.
Maniatis, T., Jeffrey, A., & Kleid, D. G. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.1184 · Cited by 2,030
Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.
Stephenson, M. L., & Zamecnik, P. C. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.285 · Cited by 906
Mizuno, T., Chou, M. Y., & Inouye, M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1966 · Cited by 695
Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.
Kozak, M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.2850 · Cited by 687
Izant, J. G., & Weintraub, H. (1984) · Cell · doi:10.1016/0092-8674(84)90050-3 · Cited by 549
Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation.
Paterson, B. M., Roberts, B. E., & Kuff, E. L. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4370 · Cited by 536
Injected anti-sense RNAs specifically block messenger RNA translation in vivo.
Melton, D. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.144 · Cited by 401
Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA
Izant, J. G., & Weintraub, H. (1985) · Science · doi:10.1126/science.2990048 · Cited by 336
Cited by
Characterization of oligonucleotide transport into living cells.
Loke, S. L., Stein, C. A., Zhang, X. H., Mori, K., Nakanishi, M., Subasinghe, C., Cohen, J. S., & Neckers, L. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3474 · Cited by 734
Progress in antisense technology
Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417
Metadata
- Authors
- Lemaitre, M., Bayard, B., & Lebleu, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-02
- Volume
- 84
- Issue
- 3
- Pages
- 648-652
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2086299962
- Cited by
- 329
- References
- 21
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. https://app.cochat.ai/papers/10.1073/pnas.84.3.648
- The paper
- Lemaitre, M., Bayard, B., & Lebleu, B. (1987). Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.3.648
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
