Cited by 278Genomics and Chromatin DynamicsCancer-related Molecular PathwaysVirus-based gene therapy research

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Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

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Kovesdi, I, Reichel, R, Nevins, J R·1987·Proceedings of the National Academy of Sciences

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Abstract

A product of the adenovirus gene E1A is responsible for the stimulation of transcription from six viral promoters as well as at least two cellular promoters. We have detected a HeLa cell factor, termed E2 promoter binding factor (E2F), that appears to mediate the transcriptional stimulation of the viral E2 promoter. Competition experiments revealed that E2F did not recognize and bind to the E1B, E3, E4, or major late promoter sequences. Furthermore, three additional promoters stimulated by E1A, heat shock protein 70, beta-globin, and early simian virus 40, do not bind E2F. In contrast, the factor does recognize sequences in the E1A enhancer, and within the E1A enhancer are duplicated binding sites for E2F. Finally, a single E2F binding site from the E1A enhancer can confer increased transcription to a mouse beta-globin promoter, dependent on the action of the E1A gene product. This stimulation requires binding of E2F since methylation of the binding site, which blocks binding in vitro, reduces transcription stimulation in vivo. We, therefore, conclude that E2F is likely to be responsible for the E1A-mediated stimulation of the E1A gene as well as the E2 gene but is not involved in the activation of the other E1A-inducible promoters.

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
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Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.
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Fried, M. G., & Crothers, D. M. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.23.6505 · Cited by 2,658
DNAase footprinting a simple method for the detection of protein-DNA binding specificity
Galas, D. J., & Schmitz, A. (1978) · Nucleic Acids Research · doi:10.1093/nar/5.9.3157 · Cited by 2,109
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Garner, M. M., & Revzin, A. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.13.3047 · Cited by 2,021
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Wigler, M. H., Pellicer, À., Silverstein, S. J., Axel, R., Urlaub, G., & Chasin, L. A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1373 · Cited by 1,278
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Doerfler, W. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.000521 · Cited by 1,094
An adenovirus type 5 early gene function regulates expression of other early viral genes.
Jones, N., & Shenk, T. E. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3665 · Cited by 733
Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs
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TPA can overcome the requirement for EIa and together act synergistically in stimulating expression of the adenovirus EIII promoter.
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Jansen‐Dürr, P., Bœuf, H., & Kédinger, C. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08499.x · Cited by 23
The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcription
Manohar, C. F., Kratochvil, J. D., & Thimmapaya, B. (1990) · Journal of Virology · doi:10.1128/jvi.64.6.2457-2466.1990 · Cited by 22
Regulation of the Cell Cycle
Li, Y., Barbash, O., & Diehl, J. A. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4066-6.00011-1 · Cited by 22
Cooperative binding of EF-1A to the E1A enhancer region mediates synergistic effects on E1A transcription during adenovirus infection
Bruder, J. T., & Hearing, P. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.5084-5087.1991 · Cited by 21
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Molloy, P. L., & Watt, F. (1990) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1990.0010 · Cited by 21
Why Don’t Germline Mutations in RB1 Predispose to Leukemia?
Phillips, R. A., Gill, R. M., Zacksenhaus, E., Bremner, R., Jiang, Z., Sopta, M., Gallie, B. L., & Hamel, P. A. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77633-5_61 · Cited by 21
Chicken Calmodulin Promoter Activity in Proliferating and Differentiated Cells
Epstein, P. N., Christenson, M. A., & Means, A. R. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-1-193 · Cited by 21
The CpG‐rich promoter of human LDH‐C is differentially methylated in expressing and nonexpressing tissues
Bonny, C., & Goldberg, E. (1995) · Developmental Genetics · doi:10.1002/dvg.1020160213 · Cited by 19
The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are essential and sufficient for E2F complex formation
O'Connor, R. J., & Hearing, P. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.23.6579 · Cited by 20
A nuclear protein with enhanced binding to methylated Sp1 sites in the AIDS virus promoter
Joel, P. B., Shao, W., & Pratt, K. R. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.24.5786 · Cited by 19
The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity
Dallaire, F., Schreiner, S., Blair, G. E., Dobner, T., Branton, P. E., & Blanchette, P. (2015) · mSphere · doi:10.1128/msphere.00015-15 · Cited by 18
Hemimethylation of DNA prevents chromatin expression.
Deobagkar, D. D., Liebler, M., Graessmann, M., & Graessmann, A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1691 · Cited by 18
Improving the Transcriptional Regulation of Genes Delivered by Adenovirus Vectors
Rubinchik, S., Woraratanadharm, J., Schepp-Berglind, J., & Dong, J.-Y. (2003) · Humana Press eBooks · doi:10.1385/1-59259-304-6:167 · Cited by 18
A nuclear protein that binds preferentially to methylated DNA in vitro may play a role in the inaccessibility of methylated CpGs in mammalian nuclei
Meehan, R. R., Antequera, F., Lewis, J., MacLeod, D., McKay, S., Kleiner, E., & Bird, A. P. (1990) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1990.0004 · Cited by 17
Transcription of the Histone H5 Gene Is Regulated by Three Differentiation-Specific Enhancers
Rousseau, S., Asselin, M., Renaud, J., & Ruiz-Carrillo, A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4904 · Cited by 17
Active beta-globin gene transcription occurs in methylated, DNase I-resistant chromatin of nonerythroid chicken cells.
Lois, R., Freeman, L. A., Villeponteau, B., & Martinson, H. G. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.1.16 · Cited by 17
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Ahmed, F. (2000) · Journal of Environmental Science and Health Part C · doi:10.1080/10590500009373517 · Cited by 17
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Duigou, G. J., & Young, C. S. H. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5437-5444.2005 · Cited by 17
An Ovine Adenovirus Vector Lacks Transforming Ability in Cells That Are Transformed by AD5 E1A/B Sequences
Xu, Z. Z., Nevels, M. M., MacAvoy, E. S., Lockett, L. J., Curiel, D. T., Dobner, T., & Both, G. W. (2000) · Virology · doi:10.1006/viro.2000.0236 · Cited by 16

Authors: Kovesdi, I., Reichel, R., & Nevins, J. R.
ORCID: Kovesdi, I
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1987-04
Volume: 84
Issue: 8
Pages: 2180-2184
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.84.8.2180
PMC: PMC304612
OpenAlex: W1968812729
Cited by: 278
References: 31
Citations by year: 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 1 · 2012: 5
FWCI: 9.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 26765)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: adenovirus E1A, transcriptional activation, viral promoters, DNA binding sites, promoter methylation, beta-globin promoter, HeLa cells
MeSH terms: Adenoviruses, Human, Base Sequence, Cell Nucleus, Genes, Genes, Viral, HeLa Cells, Humans, Oncogene Proteins, Viral, Plasmids, Promoter Regions, Genetic, Transcription Factors, Transcription, Genetic, Adenovirus Early Proteins

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Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

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