Cited by 278Genomics and Chromatin DynamicsCancer-related Molecular PathwaysVirus-based gene therapy research

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

Open access

Kovesdi, I, Reichel, R, Nevins, J R·1987·Proceedings of the National Academy of Sciences

Open this paper in CoChat — free account

Abstract

A product of the adenovirus gene E1A is responsible for the stimulation of transcription from six viral promoters as well as at least two cellular promoters. We have detected a HeLa cell factor, termed E2 promoter binding factor (E2F), that appears to mediate the transcriptional stimulation of the viral E2 promoter. Competition experiments revealed that E2F did not recognize and bind to the E1B, E3, E4, or major late promoter sequences. Furthermore, three additional promoters stimulated by E1A, heat shock protein 70, beta-globin, and early simian virus 40, do not bind E2F. In contrast, the factor does recognize sequences in the E1A enhancer, and within the E1A enhancer are duplicated binding sites for E2F. Finally, a single E2F binding site from the E1A enhancer can confer increased transcription to a mouse beta-globin promoter, dependent on the action of the E1A gene product. This stimulation requires binding of E2F since methylation of the binding site, which blocks binding in vitro, reduces transcription stimulation in vivo. We, therefore, conclude that E2F is likely to be responsible for the E1A-mediated stimulation of the E1A gene as well as the E2 gene but is not involved in the activation of the other E1A-inducible promoters.

Integrity signals

Registry

Crossref · 10.1073/pnas.84.8.2180

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.
Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
Fried, M. G., & Crothers, D. M. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.23.6505 · Cited by 2,658
DNAase footprinting a simple method for the detection of protein-DNA binding specificity
Galas, D. J., & Schmitz, A. (1978) · Nucleic Acids Research · doi:10.1093/nar/5.9.3157 · Cited by 2,109
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system
Garner, M. M., & Revzin, A. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.13.3047 · Cited by 2,021
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Wigler, M. H., Pellicer, À., Silverstein, S. J., Axel, R., Urlaub, G., & Chasin, L. A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1373 · Cited by 1,278
DNA METHYLATION AND GENE ACTIVITY
Doerfler, W. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.000521 · Cited by 1,094
An adenovirus type 5 early gene function regulates expression of other early viral genes.
Jones, N., & Shenk, T. E. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3665 · Cited by 733
Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs
Berk, A. J., Lee, F., Harrison, T. J., Williams, J., & Sharp, P. A. (1979) · Cell · doi:10.1016/0092-8674(79)90333-7 · Cited by 693

Flagged first, then by citations

Show all 31 references

Sorted by citations

Items 201–278 of 278

Evidence for a cAMP-dependent nuclear factor capable of interacting with a specific region of a eukaryotic gene.
Lee, C. Q., Miller, H. A., Schlichter, D., Dong, J. N., & Wicks, W. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4223 · Cited by 16
The -765C Allele of the Cyclooxygenase-2 Gene as a Potential Risk Factor of Colorectal Cancer: A Meta-Analysis
Cao, H., Xu, Z., Long, H., Li, X., & Li, S. (2010) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.222.15 · Cited by 15
Cell cycle‐dependent transcription of cyclin B2 is influenced by DNA methylation but is independent of methylation in the CDE and CHR elements
Tschöp, K., & Engeland, K. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06045.x · Cited by 15
Transcriptional Regulation of the Adenovirus E1A Gene
Yoshida, K., Higashino, F., & Fujinaga, K. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79586-2_6 · Cited by 14
Tumor Suppressor Genes and Clonal Evolution in B-CLL
Kay, N. E., Ranheim, E. A., & Peterson, L. C. (1995) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199509064921 · Cited by 14
E4F and ATF, Two Transcription Factors That Recognize the San Site, Can Be Distinguished Both Physically and Functionally: a Role for E4F in ElA trans Activation
Rooney, R. J., Raychaudhuri, P., & Nevins, J. R. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.10.5138-5149.1990 · Cited by 14
Self-citation
Xenogenic Adenoviral Vectors
Both, G. W. (2002) · Elsevier eBooks · doi:10.1016/b978-012199504-1/50017-1 · Cited by 14
Stepping inside the realm of epigenetic modifiers
Blum, R. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0008 · Cited by 14
Differential activation of the E2F transcription factor by the adenovirus EIa and EIV products in F9 cells.
Bœuf, H., Reimund, B., Jansen‐Dürr, P., & Kédinger, C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1782 · Cited by 12
E2F1−/−C57BL/6 Mice Overexpressing a Human Bcl-2 Transgene in B Cells Develop a Mild Autoimmune Syndrome
MARÍN, M. J., García, I., Peña, M., Bolívar, A., Zubiaga, A. M., & López‐Hoyos, M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.057 · Cited by 9
DNA Methylation and retrovirus expression
Bednarik, D. P. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9118-9_13 · Cited by 9
Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model
Tarang, S., Doi, S. M. D. S. R., Gurumurthy, C. B., Harms, D. W., Quadros, R. M., & Rocha-Sanchez, S. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00052 · Cited by 12
Breaking the Silence: The Interplay Between Transcription Factors and DNA Methylation
Baron, B. (2012) · InTech eBooks · doi:10.5772/55021 · Cited by 9
The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F
Dallaire, F., Schreiner, S., Blair, G. E., Dobner, T., Branton, P. E., & Blanchette, P. (2015) · mSphere · doi:10.1128/msphere.00014-15 · Cited by 9
E1a-dependent expression of adenovirus genes in OTF963 embryonal carcinoma cells: role of E1a-induced differentiation.
Nelson, C. C., Braithwaite, A. W., Silvestro, M., & Bellett, A. J. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.8041 · Cited by 8
Identification of a novel large F9 gene mutation?An insertion of an Alu repeated DNA element in exon e of the factor 9 gene
Wulff, K., Gazda, H. T., Schr�der, W., Rokicka-Milewska, R., & Herrmann, F. H. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200003)15:3 · Cited by 30
Epigenetic Mechanisms in the Pathophysiology of Psychotic Disorders
Ruzicka, W. B. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000048 · Cited by 7
Epigenetics in cancer and inflammation
Kawasaki, H., & Abé, H. (2012) · Personalized Medicine Universe · doi:10.1016/j.pmu.2012.05.002 · Cited by 7
The evolutionary history of the E2F and DEL genes in Viridiplantae
Rauber, R., Cabreira, C., Freitas, L. B., Turchetto‐Zolet, A. C., & Margis-Pinheiro, M. M. A. N. (2016) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2016.03.028 · Cited by 6
Functional diversity of E1A gene autoregulation among human adenoviruses
Cogan, J. D., Jones, S. N., Hall, R. K., & Tibbetts, C. (1992) · Journal of Virology · doi:10.1128/jvi.66.6.3833-3845.1992 · Cited by 6
Upstream DNA sequences determine different autoregulatory responses of the adenovirus types 5 and 3 E1A promoters
Jones, S. N., & Tibbetts, C. (1989) · Journal of Virology · doi:10.1128/jvi.63.4.1833-1838.1989 · Cited by 6
The role of the two E1a mRNA products of subgroup B adenoviruses in the regulation of early promoters of subgroup C adenoviruses
Leite, J. P. G., Collard, J. F., & D'Halluin, J.-C. (1988) · Gene · doi:10.1016/0378-1119(88)90383-6 · Cited by 6
Comprehensive bioinformatics analysis of the E2F family in human clear cell renal cell carcinoma
Liu, Z.-G., Su, J., Liu, H., Yang, X., Yang, X., Wei, Y., Zhu, X., Song, Y., Zhao, X., & Guo, H. (2022) · Oncology Letters · doi:10.3892/ol.2022.13471 · Cited by 5
Maternal Epigenetic Inheritance and Stress During Gestation
Kosten, T. A., & Nielsen, D. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405944-3.00016-7 · Cited by 5
The Role of Methylation in Regulating the Expression of the Alpha‐Fetoprotein Gene in Developing Rat Liver and Hepatoma Cell Lines
Smith, C. L., Nordloh, P. W., & Chiu, J. (1989) · Molecular Carcinogenesis · doi:10.1002/mc.2940020509 · Cited by 5
Nucleotide sequence and regulation of the adenovirus type 3 E2A early promoter
Heysen, A., Verwaerde, P., & D'Halluin, J.-C. (1991) · Virology · doi:10.1016/0042-6822(91)90489-x · Cited by 5
Active β-Globin Gene Transcription Occurs in Methylated, DNase I-Resistant Chromatin of Nonerythroid Chicken Cells
Lois, R., Freeman, L. A., Villeponteau, B., & Martinson, H. G. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.1.16-27.1990 · Cited by 5
Exploitation of Cell Cycle and Cell Death Controls by Adenoviruses: The Road to a Productive Infection
Russell, I. A., Royds, J. A., & Braithwaite, A. W. (2004) · Progress in molecular and subcellular biology · doi:10.1007/978-3-540-74264-7_11 · Cited by 5
Non-Canonical Functions of the E2F/DP Pathway with Emphasis in Plants
Sánchez-Camargo, V. A., Romero-Rodr韌uez, S., & V醶quez-Ramos, J. M. (2021) · Phyton · doi:10.32604/phyton.2021.014967 · Cited by 5
Chemical Carcinogenesis and Epigenetics
Darwanto, A., Ornam, J. D. V., Lao, V. V., & Sowers, L. C. (2010) · Humana Press eBooks · doi:10.1007/978-1-61737-995-6_12 · Cited by 4
Modulation of Cellular Genes by Oncogenes
Lebovitz, R. M., & Lieberman, M. W. (1988) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60610-8 · Cited by 4
Encounters with adenovirus
Pettersson, U. (2019) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2019.1613698 · Cited by 3
Transcription of the Histone H5 Gene Is Regulated by Three Differentiation-Specific Enhancers
Rousseau, S., Asselin, M., Renaud, J., & Ruiz-Carrillo, A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4904-4917.1993 · Cited by 3
Comprehensive review regarding the association of E2Fs with the prognosis and immune infiltrates in human head and neck squamous cell carcinoma
Du, W., Xia, X., Gou, Q., Xie, Y., & Gao, L. (2024) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2024.01.130 · Cited by 2
Malignant Gliomas: Role of E2F1 Transcription Factor
Alonso, M. M., Fueyo-Margareto, J., & Gomez‐Manzano, C. (2011) · Springer eBooks · doi:10.1007/978-94-007-0344-5_10 · Cited by 2
Cell Cycle Control in Pancreatic Cancer Pathogenesis
Lewis, B. C. (2009) · Springer eBooks · doi:10.1007/978-0-387-77498-5_13 · Cited by 2
Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy.
Long, N., Hardivillé, S., Pierce, A., Fukamachi, K., Futakuchi, M., Alexander, D. B., Shirai, T., & Tsuda, H. (2009) · PubMed · Cited by 2
How does polyunsaturated fatty acid biosynthesis regulate T‐lymphocyte function?
Fielding, B. A., Calder, P. C., Irvine, N. A., Miles, E. A., Lillycrop, K. A., von Gerichten, J., & Burdge, G. C. (2019) · Nutrition Bulletin · doi:10.1111/nbu.12404 · Cited by 3
Regulation of the Cell Cycle
Barbash, O., & Diehl, J. A. (2008) · Elsevier eBooks · doi:10.1016/b978-141603703-3.10013-5 · Cited by 2
Molecular Mechanisms of Transformation by Epstein-Barr Virus
Sung, N. S., & Pagano, J. S. (1995) · Infectious agents and pathogenesis · doi:10.1007/978-1-4899-1100-1_18 · Cited by 2
DNA Methylation: An Epigenetic mechanism in oral squamous cell carcinoma
Bhatia, V., Goel, M. M., Goel, M. M., Makker, A., & Makker, A. (2014) · South Asian Journal of Experimental Biology · doi:10.38150/sajeb.4(2).p33-41 · Cited by 1
Effect of DNA methylation on dynamic properties of the helix and nuclear protein binding in the H-ras promoter
Rachal, M. J., Holton, P., & Lapeyre, J.-N. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9118-9_14 · Cited by 1
Binding of the Transcription Factor EBP-80 Mediates the Methylation Response of an Intracistemal A-Particle Long Terminal Repeat Promoter
Falzon, M., & Kuff, E. L. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.117-125.1991 · Cited by 1
Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia
Thakur, N. (2005) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
E2F1 induction following DNA damage and oncogene activation
Helgason, G. V. (2007) · Enlighten: Theses (The University of Glasgow)
Activation of Adenovirus Gene Expression
Shenk, T. E. (1989) · Springer eBooks · doi:10.1007/978-1-4613-8890-6_6
Genetic etiology of hereditary colorectal cancer: new mechanisms and advanced mutation detection techniques
Gazzoli, I. (2006) · Utrecht University Repository (Utrecht University)
Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation
Pickering, M. (2006) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/h6jf-nf65
Identification of Mammalian E2F Regulatory Networks Using DNA Microarray Hybridization Analyses
Shannon, M. F. (2006) · CRC Press eBooks · doi:10.1201/9781498713733-10
Interação do adenovírus humano, sorotipo 41, com células origem hematopoiética: análise da permissividade celular e da expressão gênica viral.
Silva, M. L. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2008.tde-03062008-190643
Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
Herod, M. R. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham)
Untersuchungen zum Transfer von E1A-deletierten Adenoviren in vielfachresistenten Tumorzellen durch Magnetofektion
Harant, E. (2004) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2505
Estudo da interação do adenovírus humano, sorotipo 41 (HAdV-41), com células permissivas.
Silva, J. S. (2008) · doi:10.11606/t.42.2008.tde-24112008-161607
Purification and Characterization of Retinoblastoma like Factor-containing Protein Complexes from Drosophila melanogaster
Korenjak, M. (2006) · doi:10.5282/edoc.6324
Investigating the regulation of c-Fes non-receptor tyrosine kinase activation and gene expression
Shaffer, J. M. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Specific Nucleoprotein Complexes within Adenovirus Capsids
Dobner, T., Büchner, D., Zeller, T., Wolf, H. J., & Niller, H. H. (2001) · Biological Chemistry · doi:10.1515/bc.2001.169
Human adenoviruses : new bioassays for antiviral screening and CD46 interaction
Andersson, E. K. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Adenovirus Species B interactions with CD46
Gustafsson, D. J. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Single cell analysis of checkpoints in G1
Martinsson, H.-S. (2005) · Figshare
Epigenetic reprogramming in mouse germ cells
Hájková, P. (2002) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/15020
Enteric adenovirus type 41 : genome organization and specific detection procedures
Allard, A. (1992) · DiVA at Umeå University (Umeå University)
Analyse der Expression von Mutanten p53 in normalen und Tumorzellen
Deppert, W. (2000)
Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
Tutton, S. (2011) · ProQuest Demo Repository
Regulatory Mechanism of Insulin-Like Growth Factor Binding Protein-3 in Non-Small Cell Lung Cancer
Chang, Y. S., Lee, H., Kim, Y. S., Kim, H. J., Chang, J., Ahn, C., Kim, S. K., & Kim, S. K. (2004) · Tuberculosis & respiratory diseases
Molecular mechanisms of anti-proliferative effects of the Traditional Chinese Medicinal compound Rocaglamide A on cancers
Neumann, J. (2012) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00013237
Distinct E2F-Mediated Transcriptional Mechanisms in Cell Proliferation, Endoreplication and Apoptosis
Komori, H., Iwanaga, R., Bradford, A. P., Araki, K., & Ohtani, K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82448
Investigating the interaction of two human adenovirus 5 proteins: E1A and E4orf3 and the contribution of E1A C terminus on human adenovirus 5 replicative cycle
Soriano, A. M. (2018) · Mspace (University of Manitoba)
Cardiotonic Steroids Suppress Adenovirus Replication
Grosso, F. (2018) · TSpace (University of Toronto)
Global DNA Demethylation During Erythropoiesis: A Dissertation
Shearstone, J. R. (2011) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/hs36-k802
The accumulation of mutant p53 in human cancer cells
Bug, M. (2011) · doi:10.53846/goediss-3307
A statin-regulated microRNA represses c-Myc expression and function.
Takwi, A. A. (2011) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1415
Data from NGALR Is Overexpressed and Regulated by Hypomethylation in Esophageal Squamous Cell Carcinoma
Cui, L., Xu, L., Shen, Z., Tao, Q., Gao, S., Lv, Z., Du, Z., Fang, W., & Li, E. (2023) · doi:10.1158/1078-0432.c.6516790
Data from NGALR Is Overexpressed and Regulated by Hypomethylation in Esophageal Squamous Cell Carcinoma
Cui, L., Xu, L., Shen, Z., Tao, Q., Gao, S., Lv, Z., Du, Z., Fang, W., & Li, E. (2023) · doi:10.1158/1078-0432.c.6516790.v1
Human adenovirus oncolytic properties and the inhibitory role of E4 orf4 and E4 orf6/7 on endogenously activated NF-κB
Wang, A., Uchida, K., Yokoyama, A., Higashino, F., & Yasuda, M. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101616
Análise genômica viral do adenovírus humano F (HAdV-F) e do novo adenovírus humano C (HAdV-C) recombinante através de sequenciamento de nova geração e bioinformática.
Tahmasebi, R. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.3.2022.tde-08032024-111631
STRATEGIES FOR PREVENTION AND TREATMENT OF HEPATITIS C VIRUS INFECTION
Mansour, H. H. (2012) · Brock University Digital Repository (Brock University)
The FACT complex associates with the RPA complex at viral replication compartments to promote adenovirus infection
Sharmin, T., Zhao, M., Manivannan, S., Alharbi, K., Singh, K., Qashqari, F. S., Davis, S., Ward, D. G., & Turnell, A. S. (2026) · Journal of Virology · doi:10.1128/jvi.00582-26
Identification of quantitative trait loci (QTL) affectingendoreduplication and characterization of cyclin dependent kinase inhibitorsin developing maize (Zea mays L.) endosperm
Coelho, C. M. (2005) · UA Campus Repository (The University of Arizona)

Authors: Kovesdi, I., Reichel, R., & Nevins, J. R.
ORCID: Kovesdi, I
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1987-04
Volume: 84
Issue: 8
Pages: 2180-2184
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.84.8.2180
PMC: PMC304612
OpenAlex: W1968812729
Cited by: 278
References: 31
Citations by year: 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 1 · 2012: 5
FWCI: 9.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 26765)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: adenovirus E1A, transcriptional activation, viral promoters, DNA binding sites, promoter methylation, beta-globin promoter, HeLa cells
MeSH terms: Adenoviruses, Human, Base Sequence, Cell Nucleus, Genes, Genes, Viral, HeLa Cells, Humans, Oncogene Proteins, Viral, Plasmids, Promoter Regions, Genetic, Transcription Factors, Transcription, Genetic, Adenovirus Early Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks