Cited by 278Genomics and Chromatin DynamicsCancer-related Molecular PathwaysVirus-based gene therapy research

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Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

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Kovesdi, I, Reichel, R, Nevins, J R·1987·Proceedings of the National Academy of Sciences

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Abstract

A product of the adenovirus gene E1A is responsible for the stimulation of transcription from six viral promoters as well as at least two cellular promoters. We have detected a HeLa cell factor, termed E2 promoter binding factor (E2F), that appears to mediate the transcriptional stimulation of the viral E2 promoter. Competition experiments revealed that E2F did not recognize and bind to the E1B, E3, E4, or major late promoter sequences. Furthermore, three additional promoters stimulated by E1A, heat shock protein 70, beta-globin, and early simian virus 40, do not bind E2F. In contrast, the factor does recognize sequences in the E1A enhancer, and within the E1A enhancer are duplicated binding sites for E2F. Finally, a single E2F binding site from the E1A enhancer can confer increased transcription to a mouse beta-globin promoter, dependent on the action of the E1A gene product. This stimulation requires binding of E2F since methylation of the binding site, which blocks binding in vitro, reduces transcription stimulation in vivo. We, therefore, conclude that E2F is likely to be responsible for the E1A-mediated stimulation of the E1A gene as well as the E2 gene but is not involved in the activation of the other E1A-inducible promoters.

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Authors: Kovesdi, I., Reichel, R., & Nevins, J. R.
ORCID: Kovesdi, I
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1987-04
Volume: 84
Issue: 8
Pages: 2180-2184
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.84.8.2180
PMC: PMC304612
OpenAlex: W1968812729
Cited by: 278
References: 31
Citations by year: 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 1 · 2012: 5
FWCI: 9.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 26765)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: adenovirus E1A, transcriptional activation, viral promoters, DNA binding sites, promoter methylation, beta-globin promoter, HeLa cells
MeSH terms: Adenoviruses, Human, Base Sequence, Cell Nucleus, Genes, Genes, Viral, HeLa Cells, Humans, Oncogene Proteins, Viral, Plasmids, Promoter Regions, Genetic, Transcription Factors, Transcription, Genetic, Adenovirus Early Proteins

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Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

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