The DOI matches its Crossref record.
Cloning and expression of full-length cDNA encoding human vitamin D receptor.
Open accessAbstract
Complementary DNA clones encoding the human vitamin D receptor have been isolated from human intestine and T47D cell cDNA libraries. The nucleotide sequence of the 4605-base pair (bp) cDNA includes a noncoding leader sequence of 115 bp, a 1281-bp open reading frame, and 3209 bp of 3' noncoding sequence. Two polyadenylylation signals, AATAAA, are present 25 and 70 bp upstream of the poly(A) tail, respectively. RNA blot hybridization indicates a single mRNA species of approximately equal to 4600 bp. Transfection of the cloned sequences into COS-1 cells results in the production of a single receptor species indistinguishable from the native receptor. Sequence comparisons demonstrate that the vitamin D receptor belongs to the steroid-receptor gene family and is closest in size and sequence to another member of this family, the thyroid hormone receptor.
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Cited by
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Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,591
Self-citationSadeghi, K., Wessner, B., Laggner, U., Ploder, M., Tamandl, D., Friedl, J., Zügel, U., Steinmeyer, A., Pollak, A., Roth, E., et al. (2006) · European Journal of Immunology · doi:10.1002/eji.200425995 · Cited by 513
Vitamin D Receptor Signaling Mechanisms: Integrated Actions of a Well-Defined Transcription Factor
Carlberg, C., & Campbell, M. J. (2013) · Steroids · doi:10.1016/j.steroids.2012.10.019 · Cited by 293
Structure and Function of the Estrogen Receptor
PARKER, M. G., ARBUCKLE, N., DAUVOIS, S., DANIELIAN, P., & WHITE, R. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb32276.x · Cited by 129
Vitamin D, Muscle Function, and Exercise Performance
Bartoszewska, M., Kamboj, M., & Patel, D. R. (2010) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2010.03.008 · Cited by 104
Pike, J. W., & Meyer, M. B. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.03.004 · Cited by 86
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Metadata
- Authors
- Baker, A. R., McDonnell, D. P., Hughes, M., Crisp, T. M., Mangelsdorf, D. J., Haussler, M. R., Pike, J. W., Shine, J., & O'Malley, B. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-05
- Volume
- 85
- Issue
- 10
- Pages
- 3294-3298
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117263637
- Cited by
- 959
- References
- 0
- FWCI
- 33.11
- Type
- journal article
- Language
- en
- Open access
- green
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