DHEA in prenatal and postnatal life: implications for brain and behavior

Quinn, Tracey; Greaves, Ronda; Badoer, Emilio; Walker, David

doi:10.1016/bs.vh.2018.03.001

Cited by 28Sexual Differentiation and DisordersStress Responses and CortisolAdrenal Hormones and Disorders

DHEA in prenatal and postnatal life: implications for brain and behavior

Quinn, Tracey, Greaves, Ronda, Badoer, Emilio, Walker, David·2018·Vitamins and hormones

DOI 10.1016/bs.vh.2018.03.001

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Abstract

Dehydroepiandrosterone (DHEA) and its sulfated congener (DHEAS) are the principal C 19 steroid produced by the adrenal gland in many mammals, including humans. It is secreted in high concentrations during fetal life, but synthesis decreases after birth until, in humans and some other primates, there is a prepubertal surge of DHEA production by the adrenal gland-a phenomenon known as adrenarche. There remains considerable uncertainty about the physiological role of DHEA and DHEAS. Moreover, the origin of the trophic drives that determine the waxing and waning of DHEA synthesis are poorly understood. These gaps in knowledge arise in some measure from the difficulty of understanding mechanistic determinants from observations made opportunistically in humans and primates, and have stimulated a search for other suitable species that exhibit adrenarche- and adrenopause-like changes of adrenal function. DHEA and DHEAS are clearly neuroactive steroids with actions at several neurotransmitter receptors; indeed, DHEA is now known to be also synthesized by many parts of the brain, and this capacity undergoes ontogenic changes, but whether this is dependent or independent of the changes in adrenal synthesis is unknown. In this chapter we review key contributions to this field over the last 50+ years, and speculate on the importance of DHEA for the brain, both during development and for maturation and aging of cerebral function and behavior.

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The high DHEAS levels secreted from the cultured human fetal adrenal tissue are in accordance with DHEAS being the most abundant adrenal hormone produced during fetal life.
“Additionally, the high DHEAS levels secreted from the cultured HFA tissue in this study is in accordance with DHEAS being the most abundant adrenal hormone produced during fetal life (52).”
From Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis (2021) · cites this paper as [52]

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Authors: Quinn, T., Greaves, R., Badoer, E., & Walker, D.
Affiliations: Monash Medical Centre (AU)
Murdoch Children's Research Institute (AU)
RMIT University (AU)
Corresponding author: Walker, David
ORCID: Greaves, Ronda
Badoer, Emilio
Walker, David
Venue: Vitamins and hormones
Publisher: Elsevier
Published: 2018
Volume: 108
Pages: 145-174
ISSN: 0083-6729 (ISSN-L)
DOI: 10.1016/bs.vh.2018.03.001
OpenAlex: W2800699691
Cited by: 28
References: 148
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3
FWCI: 3.02
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Vitamins and hormones (publishedVersion)
PubMed (publishedVersion)
RMIT Research Repository (RMIT University Library) (submittedVersion)
Figshare (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: dehydroepiandrosterone, dehydroepiandrosterone sulfate, adrenarche, neurosteroids, prenatal development, postnatal development, brain development, brain aging, behavior, adrenal steroidogenesis, neurotransmitter receptors, primates
MeSH terms: Adrenal Cortex, Brain, Dehydroepiandrosterone, Humans, Infant, Fetal Development

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DHEA in prenatal and postnatal life: implications for brain and behavior

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