The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
Open accessAbstract
To determine which cells within the brain produce beta-amyloid mRNA and to assess expression of the beta-amyloid gene in Alzheimer disease, we analyzed brain tissue from Alzheimer and control patients by in situ hybridization. Our results demonstrate that beta-amyloid mRNA is produced by neurons in the nucleus basalis of Meynert and cerebral cortex and that nucleus basalis perikarya from Alzheimer patients consistently hybridize more beta-amyloid probe than those from controls. These observations support the hypothesis that increased expression of the beta-amyloid gene plays an important role in the deposition of amyloid in the brains of patients with Alzheimer disease.
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Cites
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611
Cited by
The molecular pathology of Alzheimer's disease
Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L., & Price, D. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1561 · Cited by 733
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“…at an early age, is often associated with mutations in APP, whereas the sporadic form, which manifests at later stages of life, is reported to be multifactorial, including induced expression of APP (Cohen et al., 1988; Palmert et al., 1988; Jacobsen et al., 1991; Rockenstein et al., 1995).”
BackgroundSecreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts
Saitoh, T., Sundsmo, M., Roch, J.-M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., & Schenk, D. B. (1989) · Cell · doi:10.1016/0092-8674(89)90096-2 · Cited by 473
Hefti, F., Hartikka, J., & Knusel, B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90118-8 · Cited by 466
Metadata
- Authors
- Cohen, M. L., Golde, T. E., Usiak, M. F., Younkin, L. H., & Younkin, S. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-02
- Volume
- 85
- Issue
- 4
- Pages
- 1227-1231
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024881555
- Cited by
- 185
- References
- 4
- FWCI
- 24.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. https://app.cochat.ai/papers/10.1073/pnas.85.4.1227
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- Cohen, M. L., Golde, T. E., Usiak, M. F., Younkin, L. H., & Younkin, S. G. (1988). In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.4.1227
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
