The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor.
Open accessAbstract
Experimental cerebral malaria (ECM), a lethal hyperacute neurological syndrome associated with high blood levels of tumor necrosis factor, develops in genetically susceptible (CBA/Ca) mice 7 days after infection with Plasmodium berghei ANKA strain. Injections of neutralizing monoclonal antibody against recombinant murine interferon gamma, not later than 4 days after infection, markedly reduced the incidence of ECM and the elevation in serum levels of tumor necrosis factor. This treatment prevented the cerebral lesions (plugging of brain vessels by monocytes, lymphocytes, and parasitized erythrocytes). In contrast, the extent of macrophage infiltration in lymphoid organs (which is a characteristic feature of mice developing ECM), as well as the course of infection, remained unaffected by the antibody treatment. Protected mice died at a later time of severe anemia and overwhelming parasitemia, the usual outcome of P. berghei infection in mice that are not susceptible to ECM. The present data indicate that interferon gamma constitutes an important link in the cytokine network that leads to brain vessel inflammation in experimental malaria. It is proposed that interferon gamma released by activated CD4+ T cells acts by augmenting both production and action of tumor necrosis factor.
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Cites
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
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Kindler, V., Sappino, A.-P., Grau, G. E., Piguet, P.-F., & Vassalli, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,254
Self-citationCharacterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
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Philip, R., & Epstein, L. B. (1986) · Nature · doi:10.1038/323086a0 · Cited by 767
Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria
Grau, G. E., Fajardo, L. F., Piguet, P.-F., Allet, B., Lambert, P.-H., & Vassalli, P. (1987) · Science · doi:10.1126/science.3306918 · Cited by 736
Self-citationγ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites
Schofield, L., Villaquiran, J., Ferreira, A., Schellekens, H., Nussenzweig, R., & Nussenzweig, V. (1987) · Nature · doi:10.1038/330664a0 · Cited by 713
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Self-citationEnhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN- gamma .
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Self-citationPurification and physico-chemical characterization of rabbit tumor necrosis factor.
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Cited by
How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria
Kwiatkowski, D. P. (2005) · The American Journal of Human Genetics · doi:10.1086/432519 · Cited by 1,104
Cytokines in acute and chronic inflammation
Wright, T. M. (1997) · Frontiers in Bioscience · doi:10.2741/a171 · Cited by 963
Immunological processes in malaria pathogenesis
Schofield, L., & Grau, G. E. (2005) · Nature Reviews Immunology · doi:10.1038/nri1686 · Cited by 688
Self-citationHeme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, Â., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1586 · Cited by 560
Lyke, K. E., Burges, R., Cissoko, Y., Sangare, L., Dao, M., Diarra, I., Kone, A., Harley, R., Plowe, C. V., Doumbo, O. K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5630-5637.2004 · Cited by 434
Metadata
- Authors
- Grau, G. E., Heremans, H., Piguet, P. F., Pointaire, P., Lambert, P. H., Billiau, A., & Vassalli, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-07
- Volume
- 86
- Issue
- 14
- Pages
- 5572-5574
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2022636507
- Cited by
- 318
- References
- 18
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Grau, G. E., Heremans, H., Piguet, P. F., Pointaire, P., Lambert, P. H., Billiau, A., & Vassalli, P. (1989). Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.14.5572
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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