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Drosophila NK-homeobox genes.
Open accessAbstract
Four Drosophila melanogaster homeobox genes were found by screening a genomic DNA library with oligodeoxynucleotides that correspond to a conserved amino acid sequence that is part of the putative of homeobox proteins that recognizes nucleotide sequences in DNA. The amino acid sequences of NK-2, NK-3, and NK-4 homeoboxes are more closely related to one another (59-66% homology) than they are to other Drosophila homeoboxes (28-54% homology), whereas the homeobox of NK-1 is most closely related, in order of decreasing homology, to muscle segment homeobox, zerknüllt-1, NK-3, and distal-less homeoboxes. Three of the genes, NK-1, NK-3, and NK-4, comprise a cluster of homeobox genes located in the 93E1-5 region of the right arm of the third chromosome, whereas the fourth homeobox gene, NK-2, is located in the 1C1-5 region of the X chromosome.
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Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C., & Kornberg, T. (1987) · Genes & Development · doi:10.1101/gad.1.1.19 · Cited by 153
Cited by
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873
Barth, K. A., & Wilson, S. W. (1995) · Development · doi:10.1242/dev.121.6.1755 · Cited by 332
Chen, C. Y., & Schwartz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15628 · Cited by 287
Depew, M. J., Tucker, A. S., & Sharpe, P. T. (2002) · Mouse Development · doi:10.1016/b978-012597951-1/50023-8 · Cited by 259
Evidence for 14 homeobox gene clusters in human genome ancestry
Pollard, S. L., & Holland, P. W. H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00676-x · Cited by 185
Metadata
- Authors
- Kim, Y., & Nirenberg, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-10
- Volume
- 86
- Issue
- 20
- Pages
- 7716-7720
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2040910893
- Cited by
- 303
- References
- 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- green
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