The DOI matches its Crossref record.
Fourier-transform mass spectrometry of large molecules by electrospray ionization.
Open accessAbstract
The multiply charged ions produced by electrospray ionization of peptides of molecular masses up to 29 kDa have been successfully introduced into a Fourier transform mass spectrometer of unique capabilities for tandem mass spectrometry, large ion dissociation, and resolution. Electrospray ionization places an unusually high number of charges on a peptide yielding mass/charge (m/z) values of 600-1500; in this range at normal operating pressures (approximately 10(-9) torr; 1 torr = 133.3 Pa) Fourier-transform mass spectrometry resolving power is greater than 100,000. Although only 10(-7) torr pressure has been obtained with the initial interface, the resulting resolving power of 5000 makes possible the resolution of isotopic peaks of multiply charged ions. Mass measuring accuracies of a few daltons for molecular masses up to 17 kDa have also been achieved.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
New developments in biochemical mass spectrometry: electrospray ionization
Smith, R. D., Loo, J. A., Edmonds, C. G., Barinaga, C. J., & Udseth, H. R. (1990) · Analytical Chemistry · doi:10.1021/ac00208a002 · Cited by 1,051
Top Down proteomics: Facts and perspectives
Catherman, A. D., Skinner, O. S., & Kelleher, N. L. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.041 · Cited by 507
“ESI-FT-ICR was first used for the analysis of intact proteins in 1989, with the detection of multiple charge states on a single protein, allowing for intact mass determination [80].”
MethodSenko, M. W., Hendrickson, C. L., Emmett, M. R., Shi, S. D. H., & Marshall, A. G. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00126-8 · Cited by 462
Senko, M. W., Beu, S. C., & McLaffertycor, F. W. (1995) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(95)00017-8 · Cited by 451
Covey, T. R., Huang, E. C., & Henion, J. D. (1991) · Analytical Chemistry · doi:10.1021/ac00013a003 · Cited by 446
Metadata
- Authors
- Henry, K. D., Williams, E. R., Wang, B. H., McLafferty, F. W., Shabanowitz, J., & Hunt, D. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-12
- Volume
- 86
- Issue
- 23
- Pages
- 9075-9078
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007196896
- Cited by
- 215
- References
- 0
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fourier-transform mass spectrometry of large molecules by electrospray ionization. https://app.cochat.ai/papers/10.1073/pnas.86.23.9075
- The paper
- Henry, K. D., Williams, E. R., Wang, B. H., McLafferty, F. W., Shabanowitz, J., & Hunt, D. F. (1989). Fourier-transform mass spectrometry of large molecules by electrospray ionization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.23.9075
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
