The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.
Open accessAbstract
To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putative antigen-recognition site (included in the first domain of the MHC molecule) and other regions of human and mouse class II genes were examined. In the putative antigen-recognition site, the rate of nonsynonymous substitution was found to exceed that of synonymous substitution, whereas in the second domain the former was significantly lower than the latter. In light of a previous theoretical study and parallel findings in class I MHC loci, we conclude that the unusually high degree of polymorphism at class II MHC loci is caused mainly by overdominant selection (heterozygote advantage) operating in the antigen-recognition site.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
Cited by
Concerted and Birth-and-Death Evolution of Multigene Families
Nei, M., & Rooney, A. P. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112240 · Cited by 1,298
Self-citationThe Nearly Neutral Theory of Molecular Evolution
Ohta, T. (1992) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.23.110192.001403 · Cited by 1,149
The evolutionary ecology of the major histocompatibility complex
Piertney, S. B., & Oliver, M. K. (2006) · Heredity · doi:10.1038/sj.hdy.6800724 · Cited by 937
The importance of immune gene variability (MHC) in evolutionary ecology and conservation
Sommer, S. (2005) · Frontiers in Zoology · doi:10.1186/1742-9994-2-16 · Cited by 913
The Influence of HLA Genotype on AIDS
Carrington, M., & O'Brien, S. J. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152346 · Cited by 722
Metadata
- Authors
- Hughes, A. L., & Nei, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-02
- Volume
- 86
- Issue
- 3
- Pages
- 958-962
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1984316285
- Cited by
- 888
- References
- 1
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. https://app.cochat.ai/papers/10.1073/pnas.86.3.958
- The paper
- Hughes, A. L., & Nei, M. (1989). Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.3.958
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
