The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Illegitimate transcription: transcription of any gene in any cell type.
Open accessAbstract
Using in vitro amplification of cDNA by the polymerase chain reaction, we have detected spliced transcripts of various tissue-specific genes (genes for anti-Müllerian hormone, beta-globin, aldolase A, and factor VIIIc) in human nonspecific cells, such as fibroblasts, hepatoma cells, and lymphoblasts. In rats, erythroid- and liver-type pyruvate kinase transcripts were also detected in brain, lung, and muscle. The abundance of these "illegitimate" transcripts is very low; yet, their existence and the possibility of amplifying them by the cDNA polymerase chain reaction provide a powerful tool to analyze pathological transcripts of any tissue-specific gene by using any accessible cell.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Weintraub, H., & Groudine, M. (1976) · Science · doi:10.1126/science.948749 · Cited by 1,809
Cited by
Gilliland, G., Perrin, S., Blanchard, K., & Bunn, H. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2725 · Cited by 1,454
Li, H., Courtois, E. T., Sengupta, D., Tan, Y., Chen, K. H., Goh, J. J. L., Kong, S. L., Chua, C., Hon, L. K., Tan, W. S., et al. (2017) · Nature Genetics · doi:10.1038/ng.3818 · Cited by 1,080
An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data
Ramsköld, D., Wang, E. T., Burge, C. B., & Sandberg, R. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000598 · Cited by 820
Mutations in the laminin α2–chain gene (LAMA2) cause merosin–deficient congenital muscular dystrophy
Helbling-Leclerc, A., Zhang, X., Topaloglu, H., Cruaud, C., Tesson, F., Weissenbach, J., Tomé, F. M. S., Schwartz, K., Fardeau, M., Tryggvason, K., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-216 · Cited by 632
Zippelius, A., Kufer, P., Honold, G., Köllermann, M. W., Oberneder, R., Schlimok, G., Riethmüller, G., & Pantel, K. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.7.2701 · Cited by 277
Metadata
- Authors
- Chelly, J., Concordet, J. P., Kaplan, J. C., & Kahn, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-04
- Volume
- 86
- Issue
- 8
- Pages
- 2617-2621
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105514165
- Cited by
- 629
- References
- 2
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Chelly, J., Concordet, J. P., Kaplan, J. C., & Kahn, A. (1989). Illegitimate transcription: transcription of any gene in any cell type. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.8.2617
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