The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.
Open accessAbstract
Transcription of mammalian genes by RNA polymerase II often begins at a specific nucleotide, whose location is determined either by an upstream DNA element known as a TATA box or by an element positioned at the transcription start site called an initiator (Inr). By in vitro analysis of synthetic promoters, we demonstrate here that the TATA and Inr elements are functionally similar and that the Inr is contained between nucleotides -3 and +5 relative to the initiation site. Moreover, we found that a mammalian transcription factor IID (TFIID) protein fraction is required for transcriptional stimulation by an Sp1-dependent activating element placed upstream of either TATA or Inr elements. However, in these assays, the yeast TATA-binding protein, which previously was shown to function similarly to mammalian TFIID, could not efficiently substitute for the mammalian TFIID fraction. These results demonstrate that mammalian TFIID is functionally distinct from the yeast TATA-binding protein and may contain additional subunits or domains that are important for transcriptional activation from some promoters.
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Cites
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Organization and Expression of Eucaryotic Split Genes Coding for Proteins
Breathnach, R., & Chambon, P. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.002025 · Cited by 4,548
The “initiator” as a transcription control element
Smale, S. T., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90176-1 · Cited by 1,535
Self-citationDynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1
Briggs, M. R., Kadonaga, J. T., Bell, S. P., & Tjian, R. (1986) · Science · doi:10.1126/science.3529394 · Cited by 1,435
Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene
McKnight, S. L., & Kingsbury, R. (1982) · Science · doi:10.1126/science.6283634 · Cited by 1,318
EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS
Johnson, P. F., & McKnight, S. L. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.004055 · Cited by 1,234
Sawadogo, M. (1985) · Cell · doi:10.1016/0092-8674(85)90021-2 · Cited by 1,171
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074
Promoter Sequences of Eukaryotic Protein-Coding Genes
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Cited by
Transcriptional coactivator complexes.
Näär, A. M., Lemon, B. D., & Tjian, R. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.475 · Cited by 571
Gill, G., Pascal, E., Tseng, Z. H., & Tjian, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.192 · Cited by 531
Cloning and Characterization of Human Estrogen Receptor β Isoforms
Moore, J. T., McKee, D. D., Slentz-Kesler, K., Moore, L. B., Jones, S. A., Horne, E. L., Su, J.-L., Kliewer, S. A., Lehmann, J. M., & Willson, T. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8738 · Cited by 511
YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro
Seto, E., Shi, Y., & Shenk, T. (1991) · Nature · doi:10.1038/354241a0 · Cited by 447
The RNA polymerase II core promoter — the gateway to transcription
Juven-Gershon, T., Hsu, J.-Y., Theisen, J. W., & Kadonaga, J. T. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.03.003 · Cited by 367
Metadata
- Authors
- Smale, S. T., Schmidt, M. C., Berk, A. J., & Baltimore, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 12
- Pages
- 4509-4513
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1999156595
- Cited by
- 481
- References
- 31
- FWCI
- 20.13
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. https://app.cochat.ai/papers/10.1073/pnas.87.12.4509
- The paper
- Smale, S. T., Schmidt, M. C., Berk, A. J., & Baltimore, D. (1990). Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.12.4509
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
