The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Chemical carcinogenesis: too many rodent carcinogens.
Open accessAbstract
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed.
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Cites
Genetic Alterations during Colorectal-Tumor Development
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The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
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Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
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Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,725
Self-citationAllelotype of Colorectal Carcinomas
Vogelstein, B., Fearon, E. R., Kern, S. E., Hamilton, S. R., Preisinger, A. C., Nakamura, Y., & White, R. (1989) · Science · doi:10.1126/science.2565047 · Cited by 1,304
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106
Self-citationOncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.
Weinberg, R. A. (1989) · PubMed · Cited by 949
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis
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Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
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Self-citation
Cited by
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Self-citationHarman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902
Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis
Ames, B. N., & Gold, L. S. (1990) · Science · doi:10.1126/science.2136249 · Cited by 770
Self-citationCollins, A. R., Ai-guo, M., & Duthie, S. J. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)00043-6 · Cited by 696
Metadata
- Authors
- Ames, B. N., & Gold, L. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-10
- Volume
- 87
- Issue
- 19
- Pages
- 7772-7776
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094536764
- Cited by
- 489
- References
- 65
- FWCI
- 25.98
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
