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The SpoOA protein of Bacillus subtilis is a repressor of the abrB gene.
Open accessAbstract
The spoOA gene of Bacillus subtilis is critical for the initial stages in the developmental cycle leading to the formation of an endospore. We show that one function of the SpoOA protein is to negatively regulate another regulatory locus, abrB, which controls the expression of many genes associated with the onset of sporulation. Purified SpoOA protein binds to a specific region of the abrB promoter and functions as a repressor of transcription in an in vitro assay. The binding of the SpoOA protein is independent of the binding of the AbrB protein, which is known to autoregulate its expression. This independence mirrors the temporal sequence of events in abrB control.
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Cited by
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Burbulys, D., Trach, K. A., & Hoch, J. A. (1991) · Cell · doi:10.1016/0092-8674(91)90238-t · Cited by 869
Self-citationThe Spo0A regulon of Bacillus subtilis
Molle, V., Fujita, M., Jensen, S. T., Eichenberger, P., González‐Pastor, J. E., Liu, J. S., & Losick, R. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03818.x · Cited by 560
The Pho regulon: a huge regulatory network in bacteria
Santos-Beneit, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00402 · Cited by 522
The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis
Hamon, M. A., & Lazazzera, B. A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02709.x · Cited by 444
Generation of multiple cell types in Bacillus subtilis
Lopez, D., Vlamakis, H., & Kolter, R. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00148.x · Cited by 381
Metadata
- Authors
- Strauch, M., Webb, V, Spiegelman, G., & Hoch, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-03
- Volume
- 87
- Issue
- 5
- Pages
- 1801-1805
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028790693
- Cited by
- 350
- References
- 0
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The SpoOA protein of Bacillus subtilis is a repressor of the abrB gene. https://app.cochat.ai/papers/10.1073/pnas.87.5.1801
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- Strauch, M., Webb, V, Spiegelman, G., & Hoch, J. A. (1990). The SpoOA protein of Bacillus subtilis is a repressor of the abrB gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.5.1801
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
