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Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.
Open accessAbstract
Growth/differentiation factor 1 (GDF-1) is a recently described member of the transforming growth factor beta superfamily isolated from a day-8.5 mouse embryo cDNA library. Northern (RNA) analysis of embryonic mRNA detected two GDF-1 transcripts [1.4 kilobases (kb) and 3.0 kb in length] displaying distinct temporal patterns of expression. Only the 3.0-kb transcript was detected in adult tissues, where its expression was restricted almost exclusively to the central nervous system. Comparison of murine and human brain cDNA sequences corresponding to the 3.0-kb transcript revealed high conservation of two nonoverlapping open reading frames with poor conservation of the intervening spacer region and the putative 5' and 3' untranslated sequences. By immunohistochemical analysis, the protein encoded by the downstream open reading frame (GDF-1) was detected exclusively in the brain, spinal cord, and peripheral nerves in day-14.5 mouse embryos. The upstream open reading frame encodes a protein of unknown function containing multiple putative membrane-spanning domains. These findings raise the possibility that this mRNA may give rise to two different proteins.
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Cited by
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Jin, S. C., Homsy, J., Zaidi, S., Lu, Q., Morton, S., DePalma, S. R., Zeng, X., Qi, H., Chang, W., Sierant, M. C., et al. (2017) · Nature Genetics · doi:10.1038/ng.3970 · Cited by 875
Levy, M., & Futerman, A. H. (2010) · IUBMB Life · doi:10.1002/iub.319 · Cited by 632
“In 1991, a mammalian gene, upstream of growth and differentiation factor-1 (UOG-1), was discovered while screening for transforming growth factor-b family members, and was found to be expressed as part of a bicistronic RNA together with growth/differentiation factor-1 (gdf1) (16).”
BackgroundMfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6
Kameya, S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.16.1879 · Cited by 134
Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity
Spassieva, S., Seo, J.-G., Jiang, J. C., Bielawski, J., Alvarez-Vasquez, F., Jazwinski, S. M., Hannun, Y. A., & Obeid, L. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608092200 · Cited by 121
Cunningham, N. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Reddi, A. H., & Lee, S.-J. (1995) · Growth Factors · doi:10.3109/08977199509028956 · Cited by 104
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Metadata
- Authors
- Lee, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-05-15
- Volume
- 88
- Issue
- 10
- Pages
- 4250-4254
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2071549023
- Cited by
- 162
- References
- 0
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, S. J. (1991). Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.10.4250
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
