Mammalian ceramide synthases
Open accessAbstract
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases. © 2010 IUBMB IUBMB Life, 62(5): 347–356, 2010
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Ceramides produced by ceramide synthases 1-6 (CerS1-6) are the central molecules in sphingolipid metabolism.
“Produced by ceramide synthases 1–6 (CerS1–6), ceramides are the central molecules in sphingolipid metabolism (12, 13, 14).”
From Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity (2025) · cites this paper as [14]
The ADAMs contain prodomain and metalloprotease domains; the fold of the metalloprotease is known, but not that of the prodomain, which has no homologs of known structure.
“The ADAMs contain prodomain and metalloprotease domains; the fold of the metalloprotease is known (23, 24), but not that of the prodomain, which has no homologs of known structure.”
From Accurate prediction of protein structures and interactions using a 3-track network (2021) · cites this paper as [24]
The Structural features section (page unavailable) describes ceramide synthase domains, not ADAMs. Searches for ADAM prodomain and metalloprotease folds found no passage addressing the claim in our copy. (LLM, conf=0.78)
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Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis
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Ceramides as Novel Disease Biomarkers
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Modulation of Ceramide Synthase Activity via Dimerization
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Novel Pathway of Ceramide Production in Mitochondria
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Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy
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Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma
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Ganglioside Metabolism in Health and Disease
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Sphingolipids and Mitochondrial Dynamic
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Membrane contact sites, ancient and central hubs of cellular lipid logistics
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Sphingolipids as Emerging Mediators in Retina Degeneration
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- Authors
- Levy, M., & Futerman, A. H.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Futerman, Anthony H.
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2010-03-10
- Volume
- 62
- Issue
- 5
- Pages
- 347-356
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- PMC
- PMC2858252
- OpenAlex
- W1989832969
- Cited by
- 632
- References
- 82
- Citations by year
- 2026: 35 · 2025: 41 · 2024: 55 · 2023: 52 · 2022: 49 · 2021: 57 · 2020: 42 · 2019: 38 · 2018: 49 · 2017: 41 · 2016: 33 · 2015: 41 · 2014: 19 · 2013: 33 · 2012: 22
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Minerva Foundation
- Israel Science Foundation
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM076217, GM 076217)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- ceramide synthase, ceramide synthesis, sphingolipid metabolism, catalytic mechanism, enzyme structure, subcellular localization, cancer, tumor suppression, chemotherapy response, apoptosis, neurodegenerative diseases
- MeSH terms
- Animals, Humans, Membrane Proteins, Neoplasms, Sphingosine, Gene Expression Regulation, Enzymologic, Tumor Suppressor Proteins, Sphingosine N-Acyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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