The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The small GTP-binding protein rab4 is associated with early endosomes.
Open accessAbstract
Small GTP-binding proteins of the rab family have been implicated as playing important roles in controlling membrane traffic on the biosynthetic and endocytic pathways. We demonstrate that a distinct rab protein, rab4p, is associated with the population of early endosomes involved in transferrin-receptor recycling. An antibody to human rab4p was found to detect a doublet of approximately 24-kDa proteins on immunoblots from various cell types. Seventy-five percent of these proteins were tightly membrane bound and could be released only by detergent treatment. Upon isolation of early endosomes, late endosomes, and lysosomes, by free-flow electrophoresis and Percoll density-gradient centrifugation, most (70%) of the rab4p was found to cofractionate with early endosomes and endocytic vesicles containing 125I-labeled transferrin. The rab proteins previously localized to the endoplasmic reticulum and/or Golgi apparatus were not found in these fractions. We also localized rab4p to transferrin-receptor-containing early endosomes by immunofluorescence after expression of rab4 cDNA. The association of rab4p with early endosomes and other vesicles involved in the intracellular transport of transferrin receptor suggests that rab4p may play a role in regulating the pathway of receptor recycling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY
MCLEAN, I. W., & NAKANE, P. K. (1974) · Journal of Histochemistry & Cytochemistry · doi:10.1177/22.12.1077 · Cited by 3,798
Kornfeld, S., & Mellman, I. (1989) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.05.110189.002411 · Cited by 1,580
Self-citationTakebe, Y., Seiki, M., Fujisawa, J.-I., Hoy, P., Yokota, K., Arai, K.-I., Yoshida, M., & Arai, N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.1.466-472.1988 · Cited by 1,330
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
Chavrier, P., Parton, R. G., Hauri, H. P., Simons, K., & Zerial, M. (1990) · Cell · doi:10.1016/0092-8674(90)90369-p · Cited by 1,166
Milburn, M. V., Tong, L., deVos, A. M., Brünger, A., Yamaizumi, Z., Nishimura, S., & Kim, S.-H. (1990) · Science · doi:10.1126/science.2406906 · Cited by 1,059
A ras-like protein is required for a post-Golgi event in yeast secretion
Salminen, A., & Novick, P. J. (1987) · Cell · doi:10.1016/0092-8674(87)90455-7 · Cited by 897
Segev, N., Mulholland, J., & Botstein, D. (1988) · Cell · doi:10.1016/0092-8674(88)90433-3 · Cited by 689
Goud, B., Salminen, A., Walworth, N. C., & Novick, P. J. (1988) · Cell · doi:10.1016/0092-8674(88)90093-1 · Cited by 585
Self-citationReceptor-mediated endocytosis of transferrin in K562 cells.
Klausner, R. D., Van Renswoude, J., Ashwell, G., Kempf, C., Schechter, A. N., Dean, A., & Bridges, K. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32481-5 · Cited by 564
Do GTPases direct membrane traffic in secretion?
Bourne, H. R. (1988) · Cell · doi:10.1016/0092-8674(88)90081-5 · Cited by 530
Cited by
ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,533
Self-citationRole of Rab GTPases in Membrane Traffic and Cell Physiology
Hutagalung, A. H., & Novick, P. J. (2011) · Physiological Reviews · doi:10.1152/physrev.00059.2009 · Cited by 1,460
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., & Zerial, M. (1992) · Cell · doi:10.1016/0092-8674(92)90306-w · Cited by 1,373
Rab11 regulates recycling through the pericentriolar recycling endosome.
Ullrich, O., Reinsch, S., Urbé, S., Zerial, M., & Parton, R. G. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.4.913 · Cited by 1,197
Rab7: A Key to Lysosome Biogenesis
Bucci, C., Thomsen, P., Nicoziani, P., McCarthy, J., & van Deurs, B. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.467 · Cited by 1,085
Metadata
- Authors
- Van Der Sluijs, P., Hull, M., Zahraoui, A., Tavitian, A., Goud, B., & Mellman, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-07-15
- Volume
- 88
- Issue
- 14
- Pages
- 6313-6317
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057087692
- Cited by
- 288
- References
- 46
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The small GTP-binding protein rab4 is associated with early endosomes. https://app.cochat.ai/papers/10.1073/pnas.88.14.6313
- The paper
- Van Der Sluijs, P., Hull, M., Zahraoui, A., Tavitian, A., Goud, B., & Mellman, I. (1991). The small GTP-binding protein rab4 is associated with early endosomes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.14.6313
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
