The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Open accessAbstract
We have investigated the in vivo functional role of rab5, a small GTPase associated with the plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein defective in GTP binding, was overexpressed in baby hamster kidney cells. In cells expressing the rab5ile 133 protein, the rate of endocytosis was decreased by 50% compared with normal, while the rate of recycling was not significantly affected. The morphology of early endosomes was also drastically changed by the mutant protein, which induced accumulation of small tubules and vesicles at the periphery of the cell. Surprisingly, overexpression of wild-type rab5 accelerated the uptake of endocytic markers and led to the appearance of atypically large early endosomes. We conclude that rab5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway.
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Self-citationrab5 controls early endosome fusion in vitro
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Self-citationEstimation of surface area from vertical sections
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Cited by
Rab proteins as membrane organizers
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Self-citationRho GTPases and signaling networks
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A brain serine/threonine protein kinase activated by Cdc42 and Rac1
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Self-citationEEA1 links PI(3)K function to Rab5 regulation of endosome fusion
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Metadata
- Authors
- Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., & Zerial, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 70
- Issue
- 5
- Pages
- 715-728
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2007797957
- Cited by
- 1,373
- References
- 67
- FWCI
- 24.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., & Zerial, M. (1992). The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell. https://doi.org/10.1016/0092-8674(92)90306-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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