The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus.
Open accessAbstract
Cyclodiene resistance represents 60% of the reported cases of insecticide resistance and is also present in vertebrates. Resistance is due to insensitivity of the cyclodiene/picrotoxinin binding site on the gamma-aminobutyric acid subtype A (GABAA) receptor-chloride ionophore complex. Following isolation of cyclodiene-resistant Drosophila mutants, we report the cloning of the locus conferring resistance via a "chromosomal walk" and rescue of the susceptible phenotype by P-element-mediated germ-line transformation. Amino acid sequence analysis of a cDNA from the locus reveals homology with vertebrate GABAA subunits. To our knowledge, this represents the first cloning of an invertebrate GABA receptor and also allows us to manipulate the resistance status of an insect via germ-line transformation. This gene may be useful as a selectable marker in other insect systems.
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Decreased expression of the GABAA receptor in fragile X syndrome
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Structure and subunit composition of GABAA receptors
Sieghart, W., Fuchs, K., Tretter, V, Ebert, V, Jechlinger, M., Höger, H., & Adamiker, D. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00045-5 · Cited by 306
McCarthy, E. V., Wu, Y., deCarvalho, T., Brandt, C., Cao, G., & Nitabach, M. N. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2017-10.2011 · Cited by 87
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Metadata
- Authors
- Ffrench-Constant, R. H., Mortlock, D. P., Shaffer, C. D., MacIntyre, R. J., & Roush, R. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-08-15
- Volume
- 88
- Issue
- 16
- Pages
- 7209-7213
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977433867
- Cited by
- 306
- References
- 20
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus. https://app.cochat.ai/papers/10.1073/pnas.88.16.7209
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- Ffrench-Constant, R. H., Mortlock, D. P., Shaffer, C. D., MacIntyre, R. J., & Roush, R. T. (1991). Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.16.7209
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