The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.
Open accessAbstract
Superoxide dismutase (SOD) rapidly scavenges superoxide (O2-) and also prolongs the vasorelaxant effects of nitric oxide (NO), thought to be the endothelium-derived relaxing factor. This prolongation has been ascribed to prevention of the reaction between O2- with NO. We report that SOD supports a reversible reduction of NO to NO-. When cyanamide and catalase were used to generate NO- in the presence of SOD, NO was measured by the conversion of HbO2 to MetHb. When SOD[Cu(I)] was exposed to NO anaerobically, NO- was trapped by MetHb forming nitrosylmyoglobin. When NO was generated by 3-morpholinosydnonimine hydrochloride in the presence of SOD, NO- or a similar reductant was formed, which reduced catalase compound II and promoted the formation of the catalase [Fe(III)]-NO complex. It is, therefore, conceivable that SOD may protect NO and endothelium-derived relaxing factor by a mechanism in addition to O2- scavenging and that NO- may be a physiologically important form of endothelium-derived relaxing factor.
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Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A. (1981) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32738-2 · Cited by 1,633
Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins
Doyle, M. P., & Hoekstra, J. W. (1981) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)80291-3 · Cited by 643
Mechanism of action of some inhibitors of endothelium-derived relaxing factor
Moncada, S., Palmer, R. M., & Gryglewski, R. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.9164 · Cited by 219
Cited by
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
The reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121
Strategies of antioxidant defense
SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976
Self-citationNitric oxide, oxidants, and protein tyrosine nitration
Radi, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307446101 · Cited by 1,457
Metadata
- Authors
- Murphy, M. E., & Sies, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-12
- Volume
- 88
- Issue
- 23
- Pages
- 10860-10864
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975021973
- Cited by
- 303
- References
- 3
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Murphy, M. E., & Sies, H. (1991). Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.23.10860
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