The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factor.
Open accessAbstract
Mutation frequency decline (MFD) is the rapid decrease in the frequency of certain induced nonsense suppressor mutations occurring when protein synthesis is transiently inhibited immediately after irradiation. MFD is abolished by mutations in the uvrA, -B, or -C genes, which prevent excision repair, or by a mfd mutation, which reduces the rate of excision but does not affect survival. Using an in vitro repair synthesis assay we found that although wild-type cells repair the transcribed (template) strand preferentially, mfd- cells are incapable of strand-specific repair. The deficiency in strand-selective repair of mfd- cell extract was corrected by adding highly purified "transcription-repair coupling factor" to the reaction mixture. We conclude that mfd is, most likely, the gene encoding the transcription-repair coupling factor.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
Witkin, E. M. (1976) · Bacteriological Reviews · doi:10.1128/br.40.4.869-907.1976 · Cited by 1,865
Self-citationMELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228
Sancar, A., & Rupp, W. D. (1983) · Cell · doi:10.1016/0092-8674(83)90354-9 · Cited by 626
Self-citationMellon, I., & Hanawalt, P. C. (1989) · Nature · doi:10.1038/342095a0 · Cited by 573
Venema, J., Mullenders, L. H. F., Natarajan, A. T., van Zeeland, A. A., & Mayne, L. V. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4707 · Cited by 552
Methyl-directed repair of DNA base-pair mismatches in vitro.
Lu, A.-L., Clark, S., & Modrich, P. L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.15.4639 · Cited by 340
ULTRAVIOLET-INDUCED MUTATION AND DNA REPAIR
Witkin, E. M. (1969) · Annual Review of Microbiology · doi:10.1146/annurev.mi.23.100169.002415 · Cited by 340
Self-citationRadiation-Induced Mutations and Their Repair
Witkin, E. M. (1966) · Science · doi:10.1126/science.152.3727.1345 · Cited by 328
Self-citationTime, Temperature, and Protein Synthesis: A Study of Ultraviolet-Induced Mutation in BacteriaPreprint
Witkin, E. M. (1956) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1956.021.01.011 · Cited by 308
Self-citation
Cited by
Sorted by citations
Items 201–215 of 215
Aßenmacher, N. (2006) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.6371 · Cited by 1
Intragenomic Hierarchies of DNA Damage Recognition
Naegeli, H. (1997) · Molecular biology intelligence unit · doi:10.1007/978-1-4684-6468-9_9 · Cited by 1
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. E. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch7 · Cited by 2
DNA repair and protection mechanisms in Escherichia coli and Mycobacterium tuberculosis
Pasquale, P. D. (2014)
MINIREVIEW Transcription-Repair
andMutation, C. (1993)
Evelyn M. Witkin Awarded the National Medal of Science
Sweasy, J. B. (2004) · Radiation Research · doi:10.1667/3150
Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli
Zhao, Y. (2015) · DSpace@MIT (Massachusetts Institute of Technology)
The roles of transcription factors in Nucleotide excision repair in yeast
Ding, B. (2010) · Louisiana State University · doi:10.31390/gradschool_dissertations.3791
Li, C. M., Lingeman, R. G., Haratipour, P., Gu, L., Jossart, J. N., Perry, J. J. P., Hickey, R. J., & Malkas, L. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00195-4
Brewer, J. J., Llewellyn, E., Chen, J., Campbell, E., & Darst, S. A. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag698
Molecular Recognition Strategies II: (A)BC Excinuclease
Naegeli, H. (1997) · Molecular biology intelligence unit · doi:10.1007/978-1-4684-6468-9_5
Juste, G. A. (2010) · Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona)
Dynamic and maintenance of constitutive heterochromatin in response to UV exposure
Berens, P. J. T. (2022) · theses.fr (ABES) · doi:10.70675/15fdfdfdz434fz4d53z9e63za9a6b512c718
Metadata
- Authors
- Selby, C. P., Witkin, E. M., & Sancar, A.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-12-15
- Volume
- 88
- Issue
- 24
- Pages
- 11574-11578
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC53178
- OpenAlex
- W2153139649
- Cited by
- 215
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM032833, GM32833)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- strand-specific repair, excision repair, DNA repair, Escherichia coli
- MeSH terms
- Alleles, Bacterial Proteins, Cell-Free System, DNA Repair, Escherichia coli, Genes, Bacterial, Genetic Complementation Test, Mutation, Phenotype, Plasmids, SOS Response, Genetics, Transcription Factors, Transcription, Genetic, Ultraviolet Rays, Genes, Suppressor, Mutagenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
