The DOI matches its Crossref record.
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
Open accessAbstract
We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.
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Cited by
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Self-citationde Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
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Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977
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Volkening, J. D., Spatz, S. J., Garcia, M., Ross, T. A., Maekawa, D. A., Rosenthal, K. S., Zamora, A. C., Skipper, A., Blakey, J. R., & Paudel, R. (2025) · PLOS Pathogens · doi:10.1371/journal.ppat.1013219 · Cited by 1
Metadata
- Authors
- Vieira, P., de Waal-Malefyt, R., Dang, M. N., Johnson, K. E., Kastelein, R., Fiorentino, D. F., deVries, J. E., Roncarolo, M. G., Mosmann, T. R., & Moore, K. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-02-15
- Volume
- 88
- Issue
- 4
- Pages
- 1172-1176
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2055336483
- Cited by
- 739
- References
- 0
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- green
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