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Expression cloning of a rat brain somatostatin receptor cDNA.
Open accessAbstract
We have used an expression-cloning strategy to isolate a cDNA encoding a somatostatin (somatotropin release-inhibiting factor, SRIF) receptor from rat cortex and hippocampus. A positive clone was identified by autoradiography after binding of radiolabeled SRIF to COS-1 cells previously transfected with pools of cDNA clones. The deduced amino acid sequence of the receptor displays sequence and structural homology to the family of G-protein-coupled receptors. The affinity of various SRIF analogs to the expressed receptor resembles their effects on growth hormone release from pituitary cells. In addition, the distribution of the mRNA in various tissues corresponds to that described for native SRIF receptors. Therefore, we conclude that we have isolated a rat brain SRIF receptor cDNA.
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Citations
Cited by
Somatostatin and Its Receptor Family
Patel, Y. C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0183 · Cited by 1,648
Peptidomimetics for Receptor Ligands—Discovery, Development, and Medical Perspectives
Giannis, A., & Kolter, T. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199312441 · Cited by 784
Rohrer, S. P., Birzin, E. T., Mosley, R. T., Berk, S. C., Hutchins, S. M., Shen, D.-M., Xiong, Y., Hayes, E. C., Parmar, R. M., Foor, F., et al. (1998) · Science · doi:10.1126/science.282.5389.737 · Cited by 458
Selective targeting of somatostatin receptor 3 to neuronal cilia
Händel, M., Schulz, S., Stanarius, A., Schreff, M., Erdtmann-Vourliotis, M., Schmidt, H., Wolf, G., & Höllt, V (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00354-6 · Cited by 386
Molecular cloning and functional expression of a brain-specific somatostatin receptor.
Bruno, J. F., Xu, Y., Song, J., & Berelowitz, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11151 · Cited by 294
Metadata
- Authors
- Kluxen, F. W., Bruns, C., & Lübbert, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-05-15
- Volume
- 89
- Issue
- 10
- Pages
- 4618-4622
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058484249
- Cited by
- 198
- References
- 0
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Kluxen, F. W., Bruns, C., & Lübbert, H. (1992). Expression cloning of a rat brain somatostatin receptor cDNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.10.4618
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