The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry
Abstract
Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of known peptide agonists. In vitro experiments using these selective compounds demonstrated the role of the somatostatin subtype-2 receptor in inhibition of glucagon release from mouse pancreatic alpha cells and the somatostatin subtype-5 receptor as a mediator of insulin secretion from pancreatic beta cells. Both receptors regulated growth hormone release from the rat anterior pituitary gland. The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,532
Reichlin, S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312153092406 · Cited by 1,044
Yamada, Y., Post, S. R., Wang, K., Tager, H. S., Bell, G. I., & Seino, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.251 · Cited by 753
Somatostatin in the central nervous system: Physiology and pathological modifications
Epelbaum, J. (1986) · Progress in Neurobiology · doi:10.1016/0301-0082(86)90012-2 · Cited by 466
Buscail, L., Delesque, N., Estève, J. P., Saint-Laurent, N., Prats, H., Clerc, P., Robberecht, P., Bell, G. I., Liebow, C., & Schally, A. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2315 · Cited by 327
Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
Yasuda, K., Rens-Domiano, S., Breder, C. D., Law, S. F., Saper, C. B., Reisine, T., & Bell, G. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)88719-7 · Cited by 309
Effects of Somatostatin on the Secretion of Thyrotropin and Prolactin
VALE, W., RIVIER, C., BRAZEAU, P., & GUILLEMIN, R. (1974) · Endocrinology · doi:10.1210/endo-95-4-968 · Cited by 299
Raynor, K., Murphy, W. A., Coy, D. H., Taylor, J. E., Moreau, J. P., Yasuda, K., Bell, G. I., & Reisine, T. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13664-x · Cited by 280
Cloning and expression of a novel mouse somatostatin receptor (SSTR2B)
Vanetti, M., Kouba, M., Wang, X., Vogt, G., & Höllt, V. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81122-3 · Cited by 269
Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Somatostatin and Its Receptor Family
Patel, Y. C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0183 · Cited by 1,648
Bruns, C., Lewis, I., Briner, U., Meno-Tetang, G., & Weckbecker, G. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460707 · Cited by 692
Reubi, J., Waser, B., Schaer, J.-C., & Laissue, J. A. (2001) · European Journal of Nuclear Medicine · doi:10.1007/s002590100541 · Cited by 657
Opportunities in somatostatin research: biological, chemical and therapeutic aspects
Weckbecker, G., Lewis, I., Albert, R., Schmid, H. A., Hoyer, D., & Bruns, C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1255 · Cited by 559
Metadata
- Authors
- Rohrer, S. P., Birzin, E. T., Mosley, R. T., Berk, S. C., Hutchins, S. M., Shen, D.-M., Xiong, Y., Hayes, E. C., Parmar, R. M., Foor, F., Mitra, S. W., Degrado, S. J., Shu, M., Klopp, J. M., Cai, S.-J., Blake, A., Chan, W. W. S., Pasternak, A., Yang, L., Patchett, A. A., Smith, R. G., Chapman, K. T., & Schaeffer, J. M.
- Venue
- Science
- Published
- 1998-10-23
- Volume
- 282
- Issue
- 5389
- Pages
- 737-740
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2156515964
- Cited by
- 458
- References
- 22
- FWCI
- 38.10
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry. https://app.cochat.ai/papers/10.1126/science.282.5389.737
- The paper
- Rohrer, S. P., Birzin, E. T., Mosley, R. T., Berk, S. C., Hutchins, S. M., Shen, D.-M., Xiong, Y., Hayes, E. C., Parmar, R. M., Foor, F., Mitra, S. W., Degrado, S. J., Shu, M., Klopp, J. M., Cai, S.-J., Blake, A., Chan, W. W. S., Pasternak, A., Yang, L., . . . Schaeffer, J. M. (1998). Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry. Science. https://doi.org/10.1126/science.282.5389.737
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
