The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Aerosol gene delivery in vivo.
Open accessAbstract
The ability to express transgenes selectively within the lung will greatly facilitate the development of gene therapy for a variety of human diseases. We have demonstrated that aerosol administration of a chloramphenicol acetyltransferase (CAT) expression plasmid complexed to cationic liposomes produces high-level, lung-specific CAT gene expression in mice in vivo. Significant levels of CAT activity are seen in the lungs for at least 21 days following aerosolization. In situ immunostaining for intracellular CAT protein reveals that the majority of airway epithelial and alveolar lining cells are transfected in vivo. Histological analyses show no apparent treatment-related damage. These results have important implications for the development of human gene therapy.
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Cites
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Cited by
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Self-citation
Metadata
- Authors
- Stribling, R., Brunette, E., Liggitt, D., Gaensler, K., & Debs, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-12
- Volume
- 89
- Issue
- 23
- Pages
- 11277-11281
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1980969709
- Cited by
- 270
- References
- 25
- FWCI
- 23.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Stribling, R., Brunette, E., Liggitt, D., Gaensler, K., & Debs, R. (1992). Aerosol gene delivery in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.23.11277
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
