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Cited by 244

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.

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Bhandari, V, Palfree, R G, Bateman, A·1992·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.89.5.1715
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Abstract

Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin homologs, epithelin 1 and 2, occur in the rat kidney. Epithelin 1, which is probably identical to rat leukocyte granulin, exhibits proliferative and antiproliferative effects on epithelial cells in vitro. Here we show by cDNA analysis that the prepropeptide for the human granulins is a 593-residue glycoprotein, containing seven tandem repeats of the 12-cysteine granulin domain. By Northern blot analysis, gene expression was seen in myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts and was seen very strongly in epithelial cell lines. Some epithelial cell lines respond to the mature peptide and express the gene. Among tissues examined, the kidney had the highest levels of granulin mRNA.

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Metadata

Authors
Bhandari, V, Palfree, R. G., & Bateman, A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1992-03
Volume
89
Issue
5
Pages
1715-1719
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.89.5.1715
OpenAlex
W2035176557
Cited by
244
References
5
FWCI
0.94
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. https://app.cochat.ai/papers/10.1073/pnas.89.5.1715
The paper
Bhandari, V, Palfree, R. G., & Bateman, A. (1992). Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.5.1715

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.