The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.
Open accessAbstract
Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus. Here we demonstrate that these mice have a defect in antigen-stimulated suicide of activated T cells in mature CD4+ and CD8+ T cell compartments. The defective suicide pathway is evident when the T cells are stimulated with antigen on antigen-presenting cells or with immobilized anti-CD3 in the absence of antigen-presenting cells. These studies, in concert with the work of others, suggest that antigen-stimulated death of mature cells may be important both in establishing peripheral tolerance and in limiting inflammation during normal immune responses.
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Metadata
- Authors
- Russell, J. H., Rush, B., Weaver, C., & Wang, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-05-15
- Volume
- 90
- Issue
- 10
- Pages
- 4409-4413
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1991476335
- Cited by
- 398
- References
- 27
- FWCI
- 19.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Russell, J. H., Rush, B., Weaver, C., & Wang, R. (1993). Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.10.4409
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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