The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.
Open accessAbstract
Long-term potentiation in the CA1 region of the hippocampus, a model for memory formation in the brain, is divided into two phases. A transient process (induction) is initiated, which then generates a persistent mechanism (maintenance) for enhancing synaptic strength. Protein kinase C (PKC), a gene family of multiple isozymes, may play a role in both induction and maintenance. In region CA1 from rat hippocampal slices, most of the isozymes of PKC translocated to the particulate fraction 15 sec after a tetanus. The increase of PKC in the particulate fraction did not persist into the maintenance phase of long-term potentiation. In contrast, a constitutively active kinase, PKM, a form specific to a single isozyme (zeta), increased in the cytosol during the maintenance phase. The transition from translocation of PKC to formation of PKM may help to explain the molecular mechanisms of induction and maintenance of long-term potentiation.
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Citations
Cites
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116
Cited by
Jiang, Y.-H., Armstrong, D., Albrecht, U., Atkins, C. M., Noebels, J. L., Eichele, G., Sweatt, J. D., & Beaudet, A. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80596-6 · Cited by 852
Storage of spatial information by the maintenance mechanism of LTP
Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006) · Science · doi:10.1126/science.1128657 · Cited by 848
Self-citationHow does PKMζ maintain long-term memory?
Sacktor, T. C. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2949 · Cited by 431
Self-citationNeural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429
Boehm, J., Kang, M.-G., Johnson, R. C., Esteban, J., Huganir, R. L., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.013 · Cited by 382
Metadata
- Authors
- Sacktor, T. C., Osten, P., Valsamis, H., Jiang, X., Naik, M. U., & Sublette, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-09-15
- Volume
- 90
- Issue
- 18
- Pages
- 8342-8346
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993968078
- Cited by
- 450
- References
- 2
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Sacktor, T. C., Osten, P., Valsamis, H., Jiang, X., Naik, M. U., & Sublette, E. (1993). Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.18.8342
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