The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.
Open accessAbstract
Epstein-Barr virus, a human herpesvirus that persists within the B-lymphoid system, can enhance the survival potential of latently infected B cells in vitro through up-regulation of the cellular survival protein Bcl-2. The possibility that an analogous effect is operative in lytically infected cells was suggested by the observation of distant sequence homology between an Epstein-Barr virus-coded early lytic cycle protein, BHRF1, and Bcl-2. Here we show by gene transfer that BHRF1 resembles Bcl-2 both in its subcellular localization and in its capacity to enhance B-cell survival. Thus confocal microscopic analysis of cells acutely cotransfected with BHRF1 and Bcl-2 expression vectors revealed substantial colocalization of the two proteins in the cytoplasm. In subsequent experiments, stable BHRF1 gene transfectants of Burkitt lymphoma cells paralleled Bcl-2 transfectants in their enhanced survival under conditions that induce cell death by apoptosis. Despite their limited sequence conservation, therefore, the two proteins appear to be functionally homologous. We suggest that BHRF1 provides an alternative, Bcl-2-independent, means of enhancing B-cell survival that may operate during the virus lytic cycle.
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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D. L., Cory, S., & Adams, J. M. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,219
Cleary, M. L., Smith, S. D., & Sklar, J. (1986) · Cell · doi:10.1016/0092-8674(86)90362-4 · Cited by 1,217
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., & Korsmeyer, S. J. (1991) · Cell · doi:10.1016/0092-8674(91)90361-2 · Cited by 1,194
Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., & Rickinson, A. (1991) · Cell · doi:10.1016/0092-8674(91)90007-l · Cited by 1,168
Self-citationMechanism of antigen-driven selection in germinal centres
Liu, Y.-J., Joshua, D. E., Williams, G. T., Smith, C. A., Gordon, J., & MacLennan, I. C. M. (1989) · Nature · doi:10.1038/342929a0 · Cited by 1,081
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
Hengartner, M. O., Ellis, R., & Horvitz, R. (1992) · Nature · doi:10.1038/356494a0 · Cited by 889
Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells
Clem, R. J., Fechheimer, M., & Miller, L. K. (1991) · Science · doi:10.1126/science.1962198 · Cited by 810
Greenspan, J. S., Greenspan, D., Lennette, E. T., Abrams, D. I., Conant, M. A., Petersen, V., & Freese, U. K. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132502 · Cited by 805
Cited by
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Death and anti-death: tumour resistance to apoptosis
Igney, F. H., & Krammer, P. H. (2002) · Nature Reviews Cancer · doi:10.1038/nrc776 · Cited by 2,075
Cohen, J. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430707 · Cited by 1,636
Miura, M. (1993) · Cell · doi:10.1016/0092-8674(93)90486-a · Cited by 1,373
Metadata
- Authors
- Henderson, S., Huen, D., Rowe, M., Dawson, C., Johnson, G., & Rickinson, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-09-15
- Volume
- 90
- Issue
- 18
- Pages
- 8479-8483
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080022600
- Cited by
- 600
- References
- 32
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Henderson, S., Huen, D., Rowe, M., Dawson, C., Johnson, G., & Rickinson, A. (1993). Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.18.8479
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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