The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.
Open accessAbstract
Gene targeting was used to produce mice deficient in intercellular adhesion molecule 1 (ICAM-1) or CD54, an immunoglobulin-like cell adhesion molecule that binds beta 2 integrins. Homozygous deficient animals develop normally, are fertile, and have a moderate granulocytosis. The nature of the mutation, RNA analysis, and immunostaining are consistent with complete loss of surface expression of ICAM-1. Deficient mice exhibit prominent abnormalities of inflammatory responses including impaired neutrophil emigration in response to chemical peritonitis and decreased contact hypersensitivity to 2,4-dinitrofluorobenzene. Mutant cells provided negligible stimulation in the mixed lymphocyte reaction, although they proliferated normally as responder cells. These mutant animals will be extremely valuable for examining the role of ICAM-1 and its counterreceptors in inflammatory disease processes and atherosclerosis.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Cited by
Intercellular adhesion molecule-1
van de Stolpe, A., & van der Saag, P. T. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00202069 · Cited by 802
Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice
Koni, P. A., Joshi, S. K., Temann, U.-A., Olson, D., Burkly, L., & Flavell, R. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.741 · Cited by 482
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, L. A., Clasper, S., Holt, A. P., Lalor, P. F., Baban, D., & Jackson, D. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051759 · Cited by 346
Lymphatic Vessel Network Structure and Physiology
Breslin, J. W., Yang, Y., Scallan, J. P., Sweat, R. S., Adderley, S. P., & Murfee, W. L. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c180015 · Cited by 341
Marchetti, L., & Engelhardt, B. (2020) · Vascular Biology · doi:10.1530/vb-19-0033 · Cited by 304
Metadata
- Authors
- Sligh, J. E., Ballantyne, C. M., Rich, S. S., Hawkins, H. K., Smith, C. W., Bradley, A., & Beaudet, A. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-09-15
- Volume
- 90
- Issue
- 18
- Pages
- 8529-8533
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2134138329
- Cited by
- 562
- References
- 1
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Sligh, J. E., Ballantyne, C. M., Rich, S. S., Hawkins, H. K., Smith, C. W., Bradley, A., & Beaudet, A. L. (1993). Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.18.8529
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
