The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.
Open accessAbstract
The rat peroxisome-proliferator-activated receptor (PPAR) was expressed in insect cells and was shown to bind to a cognate PPAR response element (PPRE) from the acyl-CoA oxidase gene. Upon purification, PPAR was no longer able to bind DNA, although binding could be restored by addition of insect cell extracts. We investigated whether the retinoid X receptor (RXR) could supplement for this accessory activity. The rat RXR alpha cDNA was cloned and it was found that addition of in vitro-translated RXR alpha to purified PPAR facilitated binding of PPAR to a PPRE. Furthermore, an additional activity, which appeared to be distinct from rRXR alpha, was found in COS cell nuclear extracts that enabled binding of PPAR to a PPRE. Transient expression of RXR alpha in CHO cells was found to be essential for the response of a chloramphenicol acetyltransferase reporter construct containing PPREs to activators of PPAR. These results raise the possibility of convergence of the PPAR and retinoid-dependent signaling pathways on promoters containing PPRE-like responsive elements.
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Cites
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05072.x · Cited by 895
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Pawlak, M., Lefebvre, P., & Staels, B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.039 · Cited by 1,578
PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
He, T.-C., Chan, T. A., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,085
Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., & Wahli, W. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.12.002 · Cited by 786
International Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496
Lipid droplets in inflammation and cancer
Bozza, P. T., & Viola, J. P. B. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.005 · Cited by 446
Metadata
- Authors
- Gearing, K. L., Göttlicher, M., Teboul, M., Widmark, E., & Gustafsson, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-02-15
- Volume
- 90
- Issue
- 4
- Pages
- 1440-1444
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081070477
- Cited by
- 395
- References
- 2
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Gearing, K. L., Göttlicher, M., Teboul, M., Widmark, E., & Gustafsson, J. A. (1993). Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.4.1440
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