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Fatty acid synthesis: a potential selective target for antineoplastic therapy
Open accessAbstract
OA-519 is a prognostic molecule found in tumor cells from breast cancer patients with markedly worsened prognosis. We purified OA-519 from human breast carcinoma cells, obtained its peptide sequence, and unambiguously identified it as fatty acid synthase through sequence homology and enzymology. Tumor fatty acid synthase is an approximately 270-kDa polypeptide which specifically abolished immunostaining of human breast cancers by anti-OA-519 antibodies. Tumor fatty acid synthase oxidized NADPH in a malonyl-CoA-dependent fashion and synthesized fatty acids composed of 80% palmitate, 10% myristate, and 10% stearate from acetyl-CoA, malonyl-CoA, and NADPH with a specific activity of 624 nmol of NADPH oxidized per min per mg. Tumor cell lines with elevated fatty acid synthase showed commensurate increases in incorporation of [U-14C]acetate into acylglycerols demonstrating that fatty acid synthase increases occur in the context of overall increases in endogenous fatty acid synthesis. Cerulenin inhibited acylglycerol synthesis in tumor cells and fibroblast controls in a dose-dependent fashion and also caused a growth inhibition which generally paralleled the level of endogenous fatty acid synthesis. Supraphysiologic levels of palmitate, 14 microM in dimethyl sulfoxide, significantly reversed the growth inhibition caused by cerulenin at concentrations of up to 5 micrograms/ml, indicating that cerulenin-mediated growth inhibition was due to fatty acid synthase inhibition.
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Cleveland, D. W., Fischer, S. G., Kirschner, M. W., & Laemmli, U. K. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75212-0 · Cited by 5,556
Fatty acid synthase, a proficient multifunctional enzyme
Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 823
A Practical Guide to Protein and Peptide Purification for Microsequencing
(1993) · Elsevier eBooks · doi:10.1016/c2009-0-03542-9 · Cited by 502
The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis
Ōmura, S. (1976) · Bacteriological Reviews · doi:10.1128/br.40.3.681-697.1976 · Cited by 403
Fletcher, J., Spector, A. A., & Ashbrook, J. D. (1971) · Biochemistry · doi:10.1021/bi00793a011 · Cited by 270
Stremmel, W., Strohmeyer, G. W., & Berk, P. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3584 · Cited by 210
WEISS, L., HOFFMANN, G. E., Schreiber, R., Andres, H. H., Fuchs, E., KÖRBER, E., & Kolb, H. J. (1986) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1986.367.2.905 · Cited by 190
Binding Site of Cerulenin in Fatty Acid Synthetase1
Funabashi, H., Kawaguchi, A., Tomoda, H., Ōmura, S., Okuda, S., & Iwasaki, S. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122739 · Cited by 179
Effects of free fatty acids on the growth of normal and neoplastic rat mammary epithelial cells.
Wicha, M. S., Liotta, L. A., & Kidwell, W. R. (1979) · PubMed · Cited by 169
Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.
Amy, C. M., Witkowski, A., Naggert, J. Κ., Williams, B., Randhawa, Z. I., & Smith, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3114 · Cited by 161
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Lau, D. S. Y., & Archer, M. C. (2009) · Nutrition and Cancer · doi:10.1080/01635580903191536 · Cited by 28
Shack, S., Chen, L., Miller, A. C., Danesi, R., & Samid, D. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910630122 · Cited by 28
The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy
Ganjoo, S., Gupta, P., Corbali, H. I., Nanez, S., Riad, T. S., Duong, L. K., Barsoumian, H. B., Masrorpour, F., Jiang, H., Welsh, J. W., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1172931 · Cited by 32
ZHENG, S.-S., Gao, J.-G., Liu, Z., ZHANG, X.-H., Wu, S., Weng, B., WANG, Y.-L., Hou, S., & Jiang, B. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4746 · Cited by 27
Lupien, L. E., Dunkley, E. M., Maloy, M. J., Lehner, I. B., Foisey, M. G., Ouellette, M. E., Lewis, L. D., Pooler, D. B., Kinlaw, W. B., & Baures, P. W. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.258947 · Cited by 27
Wang, Y., Zhang, S., Ma, X., & Tian, W. (2006) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360500472829 · Cited by 27
Kassie, F., Anderson, L., Higgins, L., Pan, Y., Matise, I., Negia, M., Upadhyaya, P., Wang, M., & Hecht, S. S. (2007) · Carcinogenesis · doi:10.1093/carcin/bgn014 · Cited by 27
Novel antagonists of the thioesterase domain of human fatty acid synthase
Richardson, R. D., & Smith, J. W. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0187 · Cited by 27
Dharmarajan, S., Newberry, E. P., Montenegro, G. A., Nalbantoglu, I., Davis, V. R., Clanahan, M. J., Blanc, V., Xie, Y., Luo, J., Fleshman, J. W., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0120 · Cited by 26
Adipose Tissue Fatty Acids in Breast Cancer Patients versus Healthy Control Women from Crete
Mamalakis, G., Hatzis, C., de Bree, E., Sanidas, E. E., Tsiftsis, D. D., Askoxylakis, J., Daskalakis, M., Tsibinos, G., & Kafatos, A. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000229508 · Cited by 26
Tuohimaa, P., Golovko, O., Kalueff, A. V., Nazarova, N., Qiao, S., Syvälä, H., Talonpoika, R., & Lou, Y. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.009 · Cited by 26
Xu, Z., Li, C., Qu, H., Li, H., Gu, Q., & Xu, J. (2017) · Tumor Biology · doi:10.1177/1010428317711324 · Cited by 26
Fort, R. S., Trinidad-Barnech, J. M., Dourron, J., Colazzo, M., Aguirre-Crespo, F. J., Duhagon, M. A., & Álvarez, G. (2018) · Pharmaceuticals · doi:10.3390/ph11030078 · Cited by 26
Jin, Y. J., Li, S.-Z., Zhao, Z., An, J. J., Kim, R. Y., Kim, Y. M., Baik, J., & Lim, S.-K. (2004) · Endocrinology · doi:10.1210/en.2004-0039 · Cited by 26
The Emerging, Multifaceted Role of WTAP in Cancer and Cancer Therapeutics
Ju, G., Lei, J., Cai, S., Liu, S., Yin, X., & Peng, C. (2023) · Cancers · doi:10.3390/cancers15113053 · Cited by 25
The dysfunctional lipids in prostate cancer.
Dang, Q., Chen, Y., & Hsieh, J. (2019) · PubMed Central · Cited by 25
Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines
Özkaya, A. B., Ak, H., Atay, S., & Aydın, H. H. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666141216150659 · Cited by 25
Inhibitory effects of four plants flavonoids extracts on fatty acid synthase
Chen, J., ZHUANG, D., Cai, W., Xu, L., Li, E., Wu, Y., & Sugiyama, K. (2009) · Journal of Environmental Sciences · doi:10.1016/s1001-0742(09)60056-5 · Cited by 25
Medium-chain fatty acids undergo elongation before β-oxidation in fibroblasts
Jones, P. M., Butt, Y. M., Messmer, B., Boriack, R. L., & Bennett, M. J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.107 · Cited by 25
Huang, H., Tang, J. P., Zhou, S., Yi, T., Peng, H., Shen, G., Xie, N., Huang, K., Yang, T., Wu, J., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1465 · Cited by 25
Elevated levels of serum fatty acid synthase in patients with gastric carcinoma
Ito, T., Sato, K., Maekawa, H., Sakurada, M., Orita, H., Shimada, K., Daida, H., Wada, R., ABE, M., Hino, O., et al. (2014) · Oncology Letters · doi:10.3892/ol.2014.1793 · Cited by 25
Novel Approaches to Imaging Tumor Metabolism
Tee, S. S., & Keshari, K. R. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000111 · Cited by 25
Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities
Turdo, A., Porcelli, G., D’Accardo, C., Franco, S. D., Verona, F., Forte, S., Giuffrida, D., Memeo, L., Todaro, M., & Stassi, G. (2020) · Cancers · doi:10.3390/cancers12061436 · Cited by 27
Brain lipogenesis and regulation of energy metabolism
López, M., & Vidal‐Puig, A. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328302f3d8 · Cited by 26
Fundamentals of Molecular Imaging: Rationale and Applications With Relevance for Radiation Oncology
Schöder, H. M., & Ong, S. C. (2008) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2007.11.006 · Cited by 25
GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells
Santana-Codina, N., Marcé‐Grau, A., Muixí, L., Nieva, C., Marro, M., Sebastián, D., Muñoz, J. P., Antonio Zorzano, A., & Sierra, À. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163883 · Cited by 25
The human fatty acid synthase: A new therapeutic target for coxsackievirus B3-induced diseases?
Rassmann, A., Henke, A., Jarasch, N., Lottspeich, F., Saluz, H., & Münder, T. (2007) · Antiviral Research · doi:10.1016/j.antiviral.2007.06.011 · Cited by 24
Weng, M., Ho, C., Ho, Y., & Lin, J.-K. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.10.021 · Cited by 24
Klawitter, J., Klawitter, J., Gurshtein, J., Corby, K., Fong, S., Tagliaferri, M. A., Quattrochi, L. C., Cohen, I. V., Shtivelman, E., & Christians, U. (2011) · International Journal of Cancer · doi:10.1002/ijc.25965 · Cited by 24
MD2 Blockage Protects Obesity‐Induced Vascular Remodeling via Activating AMPK/Nrf2
Wang, L., Han, J., Shan, P., You, S., Chen, X., Jin, Y., Wang, J., Huang, W., Wang, Y., & Liang, G. (2017) · Obesity · doi:10.1002/oby.21916 · Cited by 24
Yasuda, S., Ohkura, N., Suzuki, K., Yamasaki, M., Nishiyama, K., Kobayashi, H., Hoshi, Y., Kadooka, Y., & Igoshi, K. (2010) · Journal of Dairy Science · doi:10.3168/jds.2009-2696 · Cited by 23
Fatty Acid Synthesis in Protozoan Parasites: Unusual Pathways and Novel Drug Targets
Goodman, C., & McFadden, G. I. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784041088 · Cited by 24
The Xenopus oocyte: A model for studying the metabolic regulation of cancer cell death
Nutt, L. K. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.03.015 · Cited by 24
Alò, P., Visca, P., Mazzaferro, S., Serpieri, D. E., Mangoni, A., Botti, C., Monaco, S., Carboni, M., Zaraca, F., Trombetta, G., et al. (1999) · Annals of Diagnostic Pathology · doi:10.1016/s1092-9134(99)80024-0 · Cited by 23
CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas
Liu, D., Wang, H., Han, B. R., Meng, X., Chen, M., Yang, D., Sun, Y., Li, Y., & Jiang, C. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12531 · Cited by 23
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells
Brault, C., & Schulze, A. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_1 · Cited by 22
Sánchez-Rodríguez, J. E., Kaninda, J. P., Santos, Á., & Pérez‐Castillo, A. (2005) · Biochemical Journal · doi:10.1042/bj20042080 · Cited by 23
Mallory body forming cells express the preneoplastic hepatocyte phenotype
Li, N., Bardag‐Gorce, F., Wu, Y., Li, J., French, B. A., & French, S. W. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.11.001 · Cited by 23
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Ueno, K., & Suzuki, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13519 · Cited by 23
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Denbigh, J. L., & Lockyer, N. P. (2014) · Materials Science and Technology · doi:10.1179/1743284714y.0000000648 · Cited by 22
Menéndez, J. A., Colomer, R., & Lupu, R. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.06.032 · Cited by 22
Hamada, S., Horiguchi, A., Kuroda, K., Ito, K., Asano, T., Miyai, K., & Iwaya, K. (2014) · BMC Clinical Pathology · doi:10.1186/1472-6890-14-3 · Cited by 22
The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
Ghashghaeinia, M., Kořalková, P., Giustarini, D., Mojzíková, R., Fehrenbacher, B., Dreischer, P., Schaller, M., Mrowietz, U., Martı́nez-Ruiz, A., Wieder, T., et al. (2020) · APOPTOSIS · doi:10.1007/s10495-020-01620-6 · Cited by 22
Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk
Campa, D., McKay, J., Sinilnikova, O. M., Hüsing, A., Vogel, U. B., Hansen, R. D., Overvad, K., Witt, P. M., Clavel‐Chapelon, F., Boutron‐Ruault, M., et al. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0347-8 · Cited by 25
A pilot study of fatty acid metabolism in oral squamous cell carcinoma
Zhang, Y., Guo, C., & Yu, G. (2004) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2004.03.001 · Cited by 22
Structural studies of natural product biosynthetic proteins
Townsend, C. A. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90310-0 · Cited by 22
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Korshunov, D. A., Кондакова, И. В., & Евгеньевна, Ш. Е. (2019) · Biochemistry (Moscow) · doi:10.1134/s000629791910002x · Cited by 22
Zhang, J., Zhang, S., Lu, K., Wang, L., Song, K., Li, X., Zhang, C., & Rahimnejad, S. (2022) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2022.02.004 · Cited by 21
Zhou, Y., Su, W., Liu, H., Chen, T., Höti, N., Pei, H., & Zhu, H. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2019-0476 · Cited by 20
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Shrivastav, A. K., Kumar, G., Mittal, P., Tocher, D. R., Glencross, B. D., Chakrabarti, R., & Sharma, J. G. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.788455 · Cited by 20
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Lee, M. S., & Webb, T. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1173375 · Cited by 20
Ueda, S. M., Mao, T., Kuhajda, F. P., Vasoontara, C., Giuntoli, R. L., Bristow, R. E., Kurman, R. J., & Shih, I. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081162 · Cited by 20
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Karmali, R., Dalovisio, A. P., Borgia, J. A., Venugopal, P., Kim, B. W., Grant-Szymanski, K., Hari, P., & Lazarus, H. M. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.09.010 · Cited by 20
Guo, W., Abudumijiti, H., Xu, L., & Hasim, A. (2019) · PubMed Central · Cited by 20
Mehrandish, R., Mellati, A. A., Rahimipour, A., & Dehghan-Nayeri, N. (2016) · Razavi International Journal of Medicine · doi:10.5812/rijm.38369 · Cited by 20
Younesian, O., Kazerouni, F., Dehghan-Nayeri, N., Omrani, D., Rahimipour, A., Shanaki, M., Kalkhoran, M. R., & Cheshmi, F. (2017) · International Journal of Cancer Management · doi:10.5812/ijcm.8173 · Cited by 20
Characterization of fatty acid synthase in cell lines derived from experimental mammary tumors
Hennigar, R. A., Pochet, M., Hunt, D. A., Lukacher, A. E., Venema, V. J., Seal, E., & Marrero, M. B. (1998) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(98)00023-x · Cited by 20
Self-citationZhengdong, A., Xiaoying, X., Shuhui, F., Rui, L., Zehui, T., Guanbin, S., Yang, L., Tang, X., & Wanqian, L. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03306-4 · Cited by 20
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Pathak, S., Meng, W., Zhang, H., Gnosa, S. P., Nandy, S. K., Adell, G., Holmlund, B., & Sun, X.-F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098317 · Cited by 19
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Gaßler, N., Schneider, A., Kopitz, J., Schnölzer, M., Obermüller, N., Kartenbeck, J., Otto, H. F., & Autschbach, F. (2003) · Human Pathology · doi:10.1053/s0046-8177(03)00431-3 · Cited by 19
Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming
Nickerson, J. A., Wu, Q., & Imbalzano, A. N. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00049 · Cited by 18
Grinde, M. T., Moestue, S. A., Borgan, E., Risa, Ø., Engebraaten, O., & Gribbestad, I. S. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1683 · Cited by 18
Na, M., Hưng, T. M., Oh, W. K., Min, B. S., Lee, S. H., & Bae, K. (2010) · Phytotherapy Research · doi:10.1002/ptr.3149 · Cited by 18
Wang, J., Hudson, R., & Sintim, H. O. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.62 · Cited by 19
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Rochefort, H., & Chalbos, D. (2010) · Hormones and Cancer · doi:10.1007/s12672-010-0009-7 · Cited by 18
Hughes, D. T., Martel, P. M., Kinlaw, W. B., & Eisenberg, B. L. (2008) · Cancer Investigation · doi:10.1080/07357900701522612 · Cited by 18
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Lou, W., Gong, C., Ye, Z., Hu, Y., Zhu, M., Fang, Z., & Xu, H. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01705-y · Cited by 18
do Prado, R. F., Machado, A. L. D. S., Colombo, C. E. D., & Carvalho, Y. R. (2011) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2011.01023.x · Cited by 17
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Li, N., Tan, W., Li, J., Li, P., Lee, S., Wang, Y., & Gong, Y. (2011) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2011.22022 · Cited by 17
Rosolen, D., Kretzer, I. F., Winter, E., Noldin, V. F., do Carmo, Í. A. R., Filippin-Monteiro, F. B., Filho, V. C., & Creczynski‐Pasa, T. B. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.08.005 · Cited by 17
Jung, W. Y., Kim, Y. H., Ryu, Y. J., Kim, B., Shin, B. K., Kim, A., & Kim, H. K. (2013) · Pathology - Research and Practice · doi:10.1016/j.prp.2013.02.008 · Cited by 17
Zhao, L., Guo, J., Xu, S., Duan, M., Liu, B., Zhao, H., Wang, Y., Liu, H., Yang, Z., Yuan, H., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.016 · Cited by 18
Fatty acid metabolism and prospects for targeted therapy of cancer
Chen, T., & Li, H. (2017) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201600366 · Cited by 16
Metabolic Targeting of Malignant Tumors: Small-Molecule Inhibitors of Bioenergetic Flux
Mathupala, S. P. (2010) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489211793980114 · Cited by 16
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Hardy, R. W., Wickramasinghe, N. S. M. D., Ke, S. C., & Wells, A. H. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-2670-1_5 · Cited by 16
Zhou, Y., Zhang, X., Xu, Q., Yan, J., Yu, F. D., Xiao, J., Guo, Z., Luo, Y., & Zhong, H. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4490-3 · Cited by 15
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Hamada, S., Horiguchi, A., Asano, T., Kuroda, K., Asakuma, J., Ito, K., Asano, T., Miyai, K., & Iwaya, K. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu020 · Cited by 15
Imaging of cancer lipid metabolism in response to therapy
Arlauckas, S. P., Browning, E. A., Poptani, H., & Delikatny, E. J. (2019) · NMR in Biomedicine · doi:10.1002/nbm.4070 · Cited by 15
Hisabe, T., Yao, K., Imamura, K., Ishihara, H., Hirai, F., Matsui, T., & Iwashita, A. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3204-5 · Cited by 15
Yellen, P., & Foster, D. A. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.027 · Cited by 15
Reprogramming of fatty acid metabolism in breast cancer: a narrative review
Zhao, J., Xie, F., Yang, Y., & Wang, S. (2021) · Translational Breast Cancer Research · doi:10.21037/tbcr-20-53 · Cited by 16
Proteomics and metabolomics in cancer drug development
D’Alessandro, A., & Zolla, L. (2013) · Expert Review of Proteomics · doi:10.1586/14789450.2013.840440 · Cited by 14
Sabet, J. A., Park, L. K., Iyer, L. K., Tai, A., Koh, G. Y., Pfalzer, A. C., Parnell, L. D., Mason, J. B., Liu, Z., Byun, A. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151579 · Cited by 16
Ge, X., Ji, K., Ren, M., Mokrani, A., Mi, H., Liang, H., Xie, J., & Liu, B. (2017) · Israeli Journal of Aquaculture - Bamidgeh · doi:10.46989/001c.20842 · Cited by 14
Liu, B., Qi, P., Wang, Y., Qiu, J., Zhu, J., & Ma, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1153076 · Cited by 14
Li, X., Fu, S., Huang, Y., Luan, T., Wang, H., & Wang, J. (2021) · BMC Cancer · doi:10.1186/s12885-021-09006-w · Cited by 14
Progestins and Androgens Increase Expression of Spot 14 in T47-D Breast Tumor Cells
Heemers, H. V., Vanderhoydonc, F., Heyns, W., Verhoeven, G., & Swinnen, J. V. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2262 · Cited by 14
Guo, C.-B., Cui, N., Yu, G., Liu, D.-X., Meng, S.-C., & Song, Q. (2003) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0278-2391(03)00237-4 · Cited by 14
Tsachaki, M., Strauss, P., Dunkel, A., Navrátilová, H., Mladenovic, N., & Odermatt, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03227-w · Cited by 13
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Beebe, J., Josephraj, S., Wang, C. J., Danielson, J. A., Cui, Q., Huang, C., Barlow, L., Zhang, R. H., Zhang, T., Nakshatri, H., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00642 · Cited by 13
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Kawamura, T., Kanno, R., Fujii, H., & Suzuki, T. (2005) · Pathobiology · doi:10.1159/000089417 · Cited by 13
Fine, E. J., Segal-Isaacson, C. J., Feinman, R. D., & Sparano, J. A. (2008) · Community Oncology · doi:10.1016/s1548-5315(11)70179-6 · Cited by 13
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Metadata
- Authors
- Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Hennigar, R A
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6379-6383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44205
- OpenAlex
- W2090846942
- Cited by
- 705
- References
- 26
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 12 · 2023: 32 · 2022: 33 · 2021: 30 · 2020: 19 · 2019: 29 · 2018: 18 · 2017: 31 · 2016: 39 · 2015: 28 · 2014: 38 · 2013: 33 · 2012: 36
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- fatty acid synthase, breast cancer, cerulenin, antineoplastic therapy, fatty acid synthesis, palmitate, NADPH oxidation, malonyl-CoA, tumor growth inhibition
- MeSH terms
- Acetates, Antibodies, Antigens, Neoplasm, Blood Proteins, Breast Neoplasms, Carbon Radioisotopes, Cell Division, Cell Line, Cerulenin, Fatty Acids, Female, Haptoglobins, Humans, Immunohistochemistry, Kinetics, Malonyl Coenzyme A, Palmitic Acids, Prognosis, Tumor Cells, Cultured, Biomarkers, Tumor, Drug Design, Palmitic Acid, Fatty Acid Synthases
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