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Fatty acid synthesis: a potential selective target for antineoplastic therapy
Open accessAbstract
OA-519 is a prognostic molecule found in tumor cells from breast cancer patients with markedly worsened prognosis. We purified OA-519 from human breast carcinoma cells, obtained its peptide sequence, and unambiguously identified it as fatty acid synthase through sequence homology and enzymology. Tumor fatty acid synthase is an approximately 270-kDa polypeptide which specifically abolished immunostaining of human breast cancers by anti-OA-519 antibodies. Tumor fatty acid synthase oxidized NADPH in a malonyl-CoA-dependent fashion and synthesized fatty acids composed of 80% palmitate, 10% myristate, and 10% stearate from acetyl-CoA, malonyl-CoA, and NADPH with a specific activity of 624 nmol of NADPH oxidized per min per mg. Tumor cell lines with elevated fatty acid synthase showed commensurate increases in incorporation of [U-14C]acetate into acylglycerols demonstrating that fatty acid synthase increases occur in the context of overall increases in endogenous fatty acid synthesis. Cerulenin inhibited acylglycerol synthesis in tumor cells and fibroblast controls in a dose-dependent fashion and also caused a growth inhibition which generally paralleled the level of endogenous fatty acid synthesis. Supraphysiologic levels of palmitate, 14 microM in dimethyl sulfoxide, significantly reversed the growth inhibition caused by cerulenin at concentrations of up to 5 micrograms/ml, indicating that cerulenin-mediated growth inhibition was due to fatty acid synthase inhibition.
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Cleveland, D. W., Fischer, S. G., Kirschner, M. W., & Laemmli, U. K. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75212-0 · Cited by 5,556
Fatty acid synthase, a proficient multifunctional enzyme
Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 823
A Practical Guide to Protein and Peptide Purification for Microsequencing
(1993) · Elsevier eBooks · doi:10.1016/c2009-0-03542-9 · Cited by 502
The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis
Ōmura, S. (1976) · Bacteriological Reviews · doi:10.1128/br.40.3.681-697.1976 · Cited by 403
Fletcher, J., Spector, A. A., & Ashbrook, J. D. (1971) · Biochemistry · doi:10.1021/bi00793a011 · Cited by 270
Stremmel, W., Strohmeyer, G. W., & Berk, P. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3584 · Cited by 210
WEISS, L., HOFFMANN, G. E., Schreiber, R., Andres, H. H., Fuchs, E., KÖRBER, E., & Kolb, H. J. (1986) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1986.367.2.905 · Cited by 190
Binding Site of Cerulenin in Fatty Acid Synthetase1
Funabashi, H., Kawaguchi, A., Tomoda, H., Ōmura, S., Okuda, S., & Iwasaki, S. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122739 · Cited by 179
Effects of free fatty acids on the growth of normal and neoplastic rat mammary epithelial cells.
Wicha, M. S., Liotta, L. A., & Kidwell, W. R. (1979) · PubMed · Cited by 169
Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.
Amy, C. M., Witkowski, A., Naggert, J. Κ., Williams, B., Randhawa, Z. I., & Smith, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3114 · Cited by 161
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Fritz, V., & Fajas, L. (2010) · Oncogene · doi:10.1038/onc.2010.182 · Cited by 196
PGC1α Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis
Bhalla, K., Hwang, B. J., Dewi, R. E., Ou, L., Twaddel, W., Fang, H., Vafai, S. B., Vazquez, F., Puigserver, P., Boros, L. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1011 · Cited by 195
Tumor Abnormality-Oriented Nanomedicine Design
Zhou, Q., Xiang, J., Qiu, N., Wang, Y., Piao, Y., Shao, S., Tang, J., Zhou, Z., & Shen, Y. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00062 · Cited by 203
Thupari, J. N., Pinn, M. L., & Kuhajda, F. P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5146 · Cited by 190
Self-citationLipid desaturation – the next step in targeting lipogenesis in cancer?
Peck, B., & Schulze, A. (2016) · FEBS Journal · doi:10.1111/febs.13681 · Cited by 185
Direct Visualization of De novo Lipogenesis in Single Living Cells
Li, J., & Cheng, J. (2014) · Scientific Reports · doi:10.1038/srep06807 · Cited by 183
Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells
Little, J. L., Wheeler, F. B., Fels, D. R., Koumenis, C., & Kridel, S. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1794 · Cited by 181
Menéndez, J. A., Vellón, L., & Lupu, R. (2005) · Annals of Oncology · doi:10.1093/annonc/mdi239 · Cited by 184
Gu, L., Zhu, Y., Lin, X., Tan, X., Lu, B., & Li, Y. (2020) · Oncogene · doi:10.1038/s41388-020-1156-0 · Cited by 156
Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells
Smith, B., Schafer, X., Ambeskovic, A., Spencer, C. M., Land, H., & Munger, J. C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.045 · Cited by 172
The expanded role of fatty acid metabolism in cancer: new aspects and targets
Chen, M., & Huang, J. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz017 · Cited by 172
The Lipogenesis Pathway as a Cancer Target
Abramson, H. N. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2005805 · Cited by 167
Yang, Y., Morin, P. J., Han, W. F., Chen, T., Bornman, D. M., Gabrielson, E. W., & Pizer, E. S. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00023-x · Cited by 160
Tumor Macroenvironment and Metabolism
Zoughbi, W. A., Huang, J., Paramasivan, G. S., Till, H., Pichler, M., Guertl‐Lackner, B., & Höefler, G. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.02.005 · Cited by 163
Fatty acid synthase expression in melanoma
INNOCENZI, D., Alò, P., Balzani, A., Sebastiani, V., Silipo, V., Torre, G. L., Ricciardi, W., Bosman, C., & Calvieri, S. (2003) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2003.300104.x · Cited by 159
Piyathilake, C. J., Frost, A. R., Manne, U., Bell, W. C., Weiss, H. L., Heimburger, D. C., & Grizzle, W. E. (2000) · Human Pathology · doi:10.1053/hupa.2000.9842 · Cited by 157
Kusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T., & Suzuki, T. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800505 · Cited by 157
Zhou, W., Han, W. F., Landree, L. E., Thupari, J. N., Pinn, M. L., Bililign, T., Kim, E. K., Vadlamudi, A., Medghalchi, S. M., Meskini, R. E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3439 · Cited by 157
Self-citationVāvere, A. L., Kridel, S. J., Wheeler, F. B., & Lewis, J. S. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.046672 · Cited by 154
Sugar and fat – that's where it's at: metabolic changes in tumors
Young, C. D., & Anderson, S. M. (2008) · Breast Cancer Research · doi:10.1186/bcr1852 · Cited by 154
Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans
Ramakrishnan, S., Serricchio, M., Striepen, B., & Bütikofer, P. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.06.003 · Cited by 160
Straub, B. K., Herpel, E., Singer, S., Zimbelmann, R., Breuhahn, K., Macher‐Goeppinger, S., Warth, A., Lehmann‐Koch, J., Longerich, T., Heid, H., et al. (2010) · Modern Pathology · doi:10.1038/modpathol.2009.191 · Cited by 151
The regulation of cellular metabolism by tumor suppressor p53
Liang, Y., Liu, J., & Feng, Z. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-9 · Cited by 154
Triclosan: An Update on Biochemical and Molecular Mechanisms
Alfhili, M. A., & Lee, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1607304 · Cited by 149
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2
Knowles, L. M., Axelrod, F., Browne, C. D., & Smith, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405061200 · Cited by 146
Jin, Q., Yuan, L. X. H., Boulbés, D. R., Baek, J. M., Wang, Y., Gómez-Cabello, D., Hawke, D. H., Yeung, S. J., Lee, M. H., Hortobágyi, G. N., et al. (2010) · Breast Cancer Research · doi:10.1186/bcr2777 · Cited by 145
Clinical development of metabolic inhibitors for oncology
Lemberg, K. M., Gori, S. S., Tsukamoto, T., Rais, R., & Slusher, B. S. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148550 · Cited by 142
Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect
Weljie, A. M., & Jirik, F. R. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.009 · Cited by 143
Liu, H., Liu, J., Wu, X., & Zhang, J. (2010) · PubMed Central · Cited by 141
Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy
Schcolnik‐Cabrera, A., Chávez-Blanco, A. D., Domínguez-Gómez, G., Taja‐Chayeb, L., Morales‐Bárcenas, R., Trejo‐Becerril, C., Pérez‐Cárdenas, E., González‐Fierro, A., & Dueñas‐González, A. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1471132 · Cited by 143
Li, P., Tian, W., & Ma, X. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-138 · Cited by 138
Iga (1992) · International Journal of Oncology · doi:10.3892/ijo_00000072 · Cited by 137
Fiorentino, M., Zadra, G., Palescandolo, E., Fedele, G., Bailey, D., Fiore, C., Nguyen, P. L., Migita, T., Zamponi, R., Vizio, D. D., et al. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.97 · Cited by 136
Kusakabe, T., Nashimoto, A., Honma, K., & Suzuki, T. (2002) · Histopathology · doi:10.1046/j.1365-2559.2002.01289.x · Cited by 136
Swinnen, J. V., Beckers, A., Brusselmans, K., Organe, S., Segers, J., Timmermans, L., Vanderhoydonc, F., Deboel, L., Derua, R., Waelkens, E., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3025 · Cited by 136
Horiguchi, A., Asano, T., Asano, T., Ito, K., Sumitomo, M., & Hayakawa, M. (2008) · The Journal of Urology · doi:10.1016/j.juro.2008.04.135 · Cited by 132
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
Vatrinet, R., Leone, G., Luise, M. D., Girolimetti, G., Vidone, M., Gasparre, G., & Porcelli, A. M. (2017) · Cancer & Metabolism · doi:10.1186/s40170-017-0165-0 · Cited by 133
Oxidative metabolism in cancer growth
Ristow, M. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232892.43921.98 · Cited by 132
Bauerschlag, D., Maass, N., Leonhardt, P., Verburg, F. A., Pecks, U., Zeppernick, F. A., Morgenroth, A., Mottaghy, F. M., Tolba, R. H., Meinhold-Heerlein, I. M., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0511-3 · Cited by 129
Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in Cancer
Benjamin, D. I., Cravatt, B. F., & Nomura, D. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.013 · Cited by 131
Fatty acid metabolism as a target for obesity treatment
Ronnett, G. V., KIM, E., Landree, L. E., & TU, Y. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.04.014 · Cited by 129
Landree, L. E., Hanlon, A. L., Strong, D. W., Rumbaugh, G., Miller, I. M., Thupari, J. N., Connolly, E. C., Huganir, R. L., Richardson, C. A., Witters, L. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310991200 · Cited by 133
Self-citationFatty Acid Synthase (Fas) Predictive Strength in Poorly Differentiated Early Breast Carcinomas
Alò, P., Visca, P., Trombetta, G., Mangoni, A., Lenti, L., Monaco, S., Botti, C., Serpieri, D. E., & Tondo, U. D. (1999) · Tumori Journal · doi:10.1177/030089169908500108 · Cited by 129
Suburu, J., & Chen, Y. Q. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.03.003 · Cited by 134
Inhibition of the fungal fatty acid synthase type I multienzyme complex
Johansson, P., Wiltschi, B., Kumari, P., Keßler, B., Vonrhein, C., Vonck, J., Oesterhelt, D., & Grininger, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805827105 · Cited by 127
Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma.
Visca, P., Sebastiani, V., Botti, C., Diodoro, M. G., Lasagni, R. P., Romagnoli, F., Brenna, A., de Joannon, B. C., Donnorso, R. P., Lombardi, G., et al. (2004) · PubMed · Cited by 128
Wang, X., Song, K.-S., Guo, Q.-X., & Tian, W.-X. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00585-9 · Cited by 126
Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment
Orita, H., Coulter, J. B., Lemmon, C., Tully, E., Vadlamudi, A., Medghalchi, S. M., Kuhajda, F. P., & Gabrielson, E. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1186 · Cited by 126
Self-citationGallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery
Ashrafizadeh, M., Zarrabi, A., Mirzaei, S., Hashemi, F., Samarghandian, S., Zabolian, A., Hushmandi, K., Ang, H. L., Sethi, G., Kumar, A. P., et al. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112576 · Cited by 124
Yeh, C.-W., Chen, W.-J., Chiang, C.-T., Lin-Shiau, S.-Y., & Lin, J.-K. (2003) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500192 · Cited by 123
Copper stimulates proliferation of human endothelial cells under culture
Hu, G. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980601)69:3 · Cited by 425
Daniëls, V. W., Smans, K. A., Royaux, I. E., Chypre, M., Swinnen, J. V., & Zaidi, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106913 · Cited by 119
Ryu, B., Jones, J., Hollingsworth, M. A., Hruban, R. H., & Kern, S. E. (2001) · PubMed · Cited by 119
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice
Murata, S., Yanagisawa, K., Fukunaga, K., Oda, T., Kobayashi, A., Sasaki, R., & Ohkohchi, N. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01596.x · Cited by 120
Lupu, R., & Menéndez, J. A. (2006) · Endocrinology · doi:10.1210/en.2006-0486 · Cited by 117
Diet, lipids, and antitumor immunity
Prendeville, H., & Lynch, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00781-x · Cited by 126
Wang, Y. (., Kuhajda, F. P., Li, J. N., Pizer, E. S., Han, W. F., Sokoll, L. J., & Chan, D. W. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00464-5 · Cited by 116
Self-citationExpression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas.
Tajino, T., Kikuchi, S., & Toshimitsu, S. (2003) · PubMed · Cited by 116
Conformational flexibility of metazoan fatty acid synthase enables catalysis
Brignole, E. J., Smith, S., & Asturias, F. J. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1532 · Cited by 115
Zeng, L., Biernacka, K. M., Holly, J. M. P., Jarrett, C., Morrison, A. A., Morgan, A., Winters, Z., Foulstone, E. J., Hamilton-Shield, J. P., & Perks, C. M. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0221 · Cited by 113
Jensen, V., Ladekarl, M. B., Holm‐Nielsen, P., Melsen, F., & Sørensen, F. B. (1995) · The Journal of Pathology · doi:10.1002/path.1711760405 · Cited by 112
Enhanced Citrate Synthase Activity in Human Pancreatic Cancer
Schlichtholz, B., Turyn, J., Goyke, E., Biernacki, M., Jaśkiewicz, K., Śledziński, Z., & Świerczyński, J. (2005) · Pancreas · doi:10.1097/01.mpa.0000153326.69816.7d · Cited by 111
Menéndez, J. A., Vellón, L., Colomer, R., & Lupu, R. (2005) · International Journal of Cancer · doi:10.1002/ijc.20754 · Cited by 110
The tumor suppressor function of mitochondria: Translation into the clinics
Cuezva, J. M., Ortega, A. D., Willers, I. M., Sánchez-Cenizo, L., Aldea, M., & Sánchez‐Aragó, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.006 · Cited by 111
Minville-Walz, M., Pierre, A.-S., Pichon, L., Bellenger, S., Fèvre, C., Bellenger, J., Tessier, C., Narce, M., & Rialland, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014363 · Cited by 111
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers.
Yang, Y., Liu, H., Li, Z., Zhao, Z., Yip-Schneider, M., Fan, Q., Schmidt, C. M., Chiorean, E. G., Xie, J., Liang Cheng, C., et al. (2011) · PubMed Central · Cited by 109
Saitoh, S., Takahashi, K., Nabeshima, K., Yamashita, Y. M., Nakaseko, Y., Hirata, A., & Yanagida, M. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.949 · Cited by 109
Yun, M., Bang, S.-H., Kim, J. W., Park, J. Y., Kim, K. S., & Lee, J. D. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.062703 · Cited by 109
A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site
Hardwicke, M. A., Rendina, A. R., Williams, S. P., Moore, M. L., Wang, L., Krueger, J. A., Plant, R. N., Totoritis, R. D., Zhang, G., Briand, J., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1603 · Cited by 106
Jackowski, S., Wang, J., & Baburina, I. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00203-6 · Cited by 108
Wang, Y. Y., Cheng, P., & Chan, D. W. (2003) · PROTEOMICS · doi:10.1002/pmic.200390036 · Cited by 108
The Metabolic Alterations of Cancer Cells
Sciacovelli, M., Gaude, E., Hilvo, M., & Frezza, C. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00001-7 · Cited by 108
Inulin: A review of nutritional and health implications
Boeckner, L. S., SCHNEPF, M. I., & Tungland, B. C. (2001) · Advances in food and nutrition research · doi:10.1016/s1043-4526(01)43002-6 · Cited by 106
Browne, C. D., Hindmarsh, E. J., & Smith, J. W. (2006) · The FASEB Journal · doi:10.1096/fj.05-5404com · Cited by 105
Vanauberg, D., Schulz, C., & Lefebvre, T. (2023) · Oncogenesis · doi:10.1038/s41389-023-00460-8 · Cited by 104
AMP-activated protein kinase and human cancer: cancer metabolism revisited
Kuhajda, F. P. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.121 · Cited by 105
Self-citationMa, Y., Zha, J., Yang, X., Li, Q., Zhang, Q., Yin, A., Beharry, Z. M., Huang, H., Huang, J., Bartlett, M. G., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01667-y · Cited by 109
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study
Klawitter, J., Shokati, T., Moll, V., Christians, U., & Klawitter, J. (2010) · Breast Cancer Research · doi:10.1186/bcr2485 · Cited by 103
Relevance of Mitochondrial Genetics and Metabolism in Cancer DevelopmentPreprint
Gasparre, G., Porcelli, A. M., Lenaz, G., & Romeo, G. C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011411 · Cited by 102
Animal Fatty Acid Synthase: A Chemical Nanofactory
Paiva, P., Medina, F. E., Viegas, M. F., Ferreira, P., Neves, R. P. P., Sousa, J. P. M., Ramos, M. J., & Fernandes, P. A. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00147 · Cited by 97
Knowles, L. M., Chen, Y., Osterman, A. L., & Smith, J. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803384200 · Cited by 100
Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells
Schroeder, B., Steen, T. V., Espinoza, I. C., Venkatapoorna, C. M. K., Hu, Z., Martín, F., Regan, K. M., Cuyàs, E., Meng, X. W., Verdura, S., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04262-x · Cited by 109
Escribá, P. V. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.05.017 · Cited by 98
De novo fatty acid synthesis at the mitotic exit is required to complete cellular division
Scaglia, N., Tyekucheva, S., Zadra, G., Photopoulos, C., & Loda, M. F. (2014) · Cell Cycle · doi:10.4161/cc.27767 · Cited by 96
Huang, M., Wang, F., Zhou, X., Yang, H., & Wang, Y. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.09.008 · Cited by 97
Li, J. N., Mahmoud, M. A., Han, W. F., Ripple, M. G., & Pizer, E. S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.5054 · Cited by 95
KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
Chang, Y., Wang, J., Lu, X., Thewke, D. P., & Mason, R. J. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500154-jlr200 · Cited by 94
Menéndez, J. A., & Lupu, R. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232893.21050.15 · Cited by 94
Xiao, F., Wang, C., Yin, H., Yu, J., Chen, S., Fang, J. S., & Guo, F. (2016) · Oncotarget · doi:10.18632/oncotarget.11626 · Cited by 93
A New Class of Antituberculosis Agents
Jones, P. B., Parrish, N. M., Houston, T. A., Stapon, A., Bansal, N. P., Dick, J. D., & Townsend, C. A. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000149l · Cited by 92
Self-citationLipid biology of breast cancer
Baumann, J., Sevinsky, C. J., & Conklin, D. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.03.011 · Cited by 94
Influence of Inulin and Oligofructose on Breast Cancer and Tumor Growth
Taper, H. S., & Roberfroid, M. B. (1999) · Journal of Nutrition · doi:10.1093/jn/129.7.1488s · Cited by 92
Hopperton, K. E., Duncan, R. E., Bazinet, R. P., & Archer, M. C. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.10.016 · Cited by 91
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
Lü, S., & Archer, M. C. (2009) · International Journal of Cancer · doi:10.1002/ijc.24761 · Cited by 93
Lacasa, D., Lièpvre, X. L., Ferré, P., & Dugail, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008556200 · Cited by 91
O’Brien, A. J., Villani, L. A., Broadfield, L. A., Houde, V. P., Galić, S., Blandino, G., Kemp, B. E., Tsakiridis, T. K., Muti, P. C., & Steinberg, G. R. (2015) · Biochemical Journal · doi:10.1042/bj20150122 · Cited by 90
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Schneiter, R., & Kohlwein, S. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81882-6 · Cited by 90
Brink, J., Ludtke, S. J., Kong, Y., Wakil, S. J., Ma, J., & Chiu, W. (2004) · Structure · doi:10.1016/j.str.2004.01.015 · Cited by 90
McFadden, J. M., Medghalchi, S. M., Thupari, J. N., Pinn, M. L., Vadlamudi, A., Miller, K. I., Kuhajda, F. P., & Townsend, C. A. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049389h · Cited by 89
Self-citationScaglia, N., Caviglia, J. M., & Igal, R. A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.11.015 · Cited by 90
Metadata
- Authors
- Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Hennigar, R A
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6379-6383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44205
- OpenAlex
- W2090846942
- Cited by
- 705
- References
- 26
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 12 · 2023: 32 · 2022: 33 · 2021: 30 · 2020: 19 · 2019: 29 · 2018: 18 · 2017: 31 · 2016: 39 · 2015: 28 · 2014: 38 · 2013: 33 · 2012: 36
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- fatty acid synthase, breast cancer, cerulenin, antineoplastic therapy, fatty acid synthesis, palmitate, NADPH oxidation, malonyl-CoA, tumor growth inhibition
- MeSH terms
- Acetates, Antibodies, Antigens, Neoplasm, Blood Proteins, Breast Neoplasms, Carbon Radioisotopes, Cell Division, Cell Line, Cerulenin, Fatty Acids, Female, Haptoglobins, Humans, Immunohistochemistry, Kinetics, Malonyl Coenzyme A, Palmitic Acids, Prognosis, Tumor Cells, Cultured, Biomarkers, Tumor, Drug Design, Palmitic Acid, Fatty Acid Synthases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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